Dopamine D2 Receptor Antagonists
- Name
- Dopamine D2 Receptor Antagonists
- Accession Number
- DBCAT000879 (DBCAT003354)
- Description
Compounds and drugs that bind to and inhibit or block the activation of DOPAMINE D2 RECEPTORS.
- Drugs
Drug Drug Description Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Acetophenazine For the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.) Alizapride A dopamine antagonist used to prevent nausea and vomiting associated with medical procedures, surgeries, and cancer therapies. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. AS-8112 AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3. It has been shown to exert... Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Azaperone Azaperone is a pyridinylpiperazine and butyrophenone agent that is capable of eliciting neuroleptic sedative and antiemetic effects. It is subsequently employed predominantly as a veterinary tranquilizer and mainly for pigs... Blonanserin Used for the treatment of schizophrenia . Bromopride A substituted benzamide, closely related to metoclopramide, used as an antiemetic. Buspirone An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. Carphenazine Used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Chlorprothixene A thioxanthene antipsychotic. Clozapine An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Domperidone A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Fallypride Fallypride is under investigation in clinical trial NCT02310360 (Striatal and Extra-striatal Dopamine Release in Response to Food in Healthy Humans). Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Iloperidone An atypical antipsychotic agent used to treat schizophrenia and manic or mixed episodes associated with bipolar I disorder in adults. JNJ-37822681 JNJ-37822681 has been used in trials studying the treatment of Schizophrenia. Loxapine A antipsychotic used for the treatment of schizophrenia. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Melperone An atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Mianserin A tetracyclic antidepressant with therapeutic activity similar to amitriptyline used to treat depression and anxiety. Molindone An antipsychotic used to treat schizophrenia. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. OSU-6162 OSU-6162 is under investigation in clinical trial NCT05641623 (OSU6162 as Add-on in Ssri/snri-resistant Depression). Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Penfluridol Not Annotated Perospirone For the treatment of schizophrenia and acute cases of bipolar mania. Perphenazine A phenothiazine used to treat schizophrenia as well as nausea and vomiting. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Pipotiazine An antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Promazine A phenothiazine used to manage schizophrenia. Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Propiomazine Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. Quetiapine An atypical antipsychotic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Raclopride Raclopride has been used in trials studying Parkinson Disease. Remoxipride An discontinued atypical antipsychotic selective for dopamine D2 receptors. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Sertindole An atypical antipsychotic indicated in the treatment of schizophrenia. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Thiethylperazine A drug used for the treatment of nausea and vomiting. Thioproperazine An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Thiothixene An antipsychotic indicated for the management of schizophrenia. Tiapride A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. YKP-1358 Investigated for use/treatment in schizophrenia and schizoaffective disorders. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. - Drugs & Drug Targets