- Dopamine Antagonists
- Accession Number
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Drug Drug Description Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Thiethylperazine A drug used for the treatment of nausea and vomiting. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Loxapine A antipsychotic used for the treatment of schizophrenia. Remoxipride An discontinued atypical antipsychotic selective for dopamine D2 receptors. Promazine A phenothiazine used to manage schizophrenia. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Perphenazine A phenothiazine used to treat schizophrenia as well as nausea and vomiting. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Domperidone A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Chlorprothixene A thioxanthene antipsychotic. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Aceprometazine Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders. Thiothixene An antipsychotic indicated for the management of schizophrenia. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. YKP-1358 Investigated for use/treatment in schizophrenia and schizoaffective disorders. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Bromopride A substituted benzamide, closely related to metoclopramide, used as an antiemetic. AS-8112 AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3. It has been shown to exert... Azaperone Azaperone is a pyridinylpiperazine and butyrophenone agent that is capable of eliciting neuroleptic sedative and antiemetic effects. It is subsequently employed predominantly as a veterinary tranquilizer and mainly for pigs... Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Ecopipam Ecopipam has been used in trials studying the treatment of Tourette's Syndrome, Lesch-Nyhan Disease, Pathological Gambling, and Self-injurious Behavior. Raclopride Raclopride has been used in trials studying Parkinson Disease. JNJ-37822681 JNJ-37822681 has been used in trials studying the treatment of Schizophrenia. Perazine A phenothiazine antipsychotic used in the acute and chronic treatment of psychotic disorders. Benperidol A neuroleptic butyrophenone derivative indicated in the treatment of psychoses, manic episodes, and psychomotor agitation. Tiapride A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism. Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Clebopride A dopamine antagonist used to treat symptoms associated with functional gastrointestinal disorders. Clebopride may also be used to treat nausea and vomiting associated with chemotherapy. Trifluperidol Not Annotated Penfluridol Not Annotated Clopenthixol Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Methylergometrine An ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery. Lisuride For the management of Parkinson's Disease Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Propiomazine Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. Acetophenazine For the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.) Clozapine An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Carphenazine Used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Periciazine A phenothiazine used with other medications to treat aggressiveness, impulsiveness, and hostility associated with psychiatric conditions such as schizophrenia. Pipotiazine An antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients. Thioproperazine An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Perospirone For the treatment of schizophrenia and acute cases of bipolar mania. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Blonanserin Used for the treatment of schizophrenia . Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Buspirone An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. Molindone An antipsychotic used to treat schizophrenia. Sertindole An atypical antipsychotic indicated in the treatment of schizophrenia. Alizapride A dopamine antagonist used to prevent nausea and vomiting associated with medical procedures, surgeries, and cancer therapies. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Mianserin A tetracyclic antidepressant with therapeutic activity similar to amitriptyline used to treat depression and anxiety. Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Melperone An atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients. Fallypride Fallypride is under investigation in clinical trial NCT02310360 (Striatal and Extra-striatal Dopamine Release in Response to Food in Healthy Humans). Eticlopride Not Annotated Lumateperone A novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia.
- Drugs & Drug Targets