Cyanide Poisoning (DBCOND0053869)

Identifiers

Synonyms

Toxic effect of hydrocyanic acid and cyanides / Cyanide intoxication / Cyanide poisoning / Toxic effect of cyanides, accidental (unintentional) / Toxic effect of cyanides / Toxic effect of cyanide (disorder) / Chemical poisoning / Toxic effect of chemical (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Hydroxocobalamin	A synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning.	Methylmalonic aciduria type A protein, mitochondrialtarget Protein amnionlesstarget Transcobalamin-1target Methylmalonyl-CoA mutase, mitochondrialtarget Methionine synthasetarget Cubilintarget Cyanocobalamin reductase / alkylcobalamin dealkylasetarget Transcobalamin-2carrier
Nitrous acid	An iron binder used to reverse life-threatening acute cyanide poisoning.	Hemoglobin subunit alphatarget Hemoglobin subunit betatarget Myoglobintarget
Thiosulfuric acid	A sulfur donor used sequentially with sodium nitrite for the reversal of life-threatening acute cyanide poisoning. Also used to reduce the risk of ototoxicity associated with cisplatin.	Solute carrier family 13 member 4transporter Thiosulfate sulfurtransferaseenzyme Thiosulfate:glutathione sulfurtransferaseenzyme Cytochrome P450 2B6enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01656616	Hydroxycobalamin and Rural Emergency Medical Services Cyanide Exposure Patients: A Cost Analysis	No drug interventions	Not Available	Not Available	withdrawn
NCT05194358	Study of SIAN Nasal Spray in Healthy Adults	No drug interventions	treatment	1	completed