Nasal Congestion (DBCOND0035647)

Identifiers

Synonyms
Nasal congestion/blockage / Nasal Stuffiness / Nasal congestion / Congestion nasal / Nose congestion / Nasal congestion (finding)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Acetaminophen
An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.
Ammonium chloride
Expectorant in cough syrups. The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium...
No drug targets
Bromhexine
A mucolytic drug used to decrease the viscosity of mucus in the airway, enhancing mucus clearance.
Budesonide
A corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis.
Camphor
A compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.
Chlorpheniramine
A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.
Choline salicylate
The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due...
DL-Methylephedrine
Used as an antitussive and decongestant .
Desloratadine
A second generation tricyclic antihistamine used to treat seasonal and non seasonal allergic rhinitis, pruritus, and urticaria.
Dexpanthenol
An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).
No drug targets
Dextromethorphan
An NMDA receptor antagonist used to treat cases of dry cough.
Dimetindene
A 1st generation selective H1 antagonist used topically as an antipruritic and orally to treat allergies.
Diphenhydramine
A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
Ephedrine
An alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion.
Epinephrine
A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
Eucalyptus oil
An ingredient used in a variety of natural health products.
No drug targets
Fluticasone propionate
A glucocorticoid used to treat asthma, inflammatory pruritic dermatoses, and nonallergic rhinitis.
Guaifenesin
An expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.
Ibuprofen
An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation.
Isopropamide
A long-acting anticholinergic drug used to relieve symptoms of spastic and painful symptoms of gastrointestinal conditions and symptoms of flu, colds, and related conditions.
Levmetamfetamine
Used over-the-counter for nasal congestion.
Levocetirizine
An H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria.
Levomenthol
An organic compound used to treat mild to moderate muscle and joint pain.
Loratadine
A second generation antihistamine used to manage the symptoms of allergic rhinitis.
Naphazoline
A sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.
Naproxen
An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain.
Niaouli oil
An essential oil used to treat nasal congestion and rhinorrhea.
No drug targets
Oxymetazoline
An alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea.
Peppermint oil
An ingredient used in a variety of natural health products and is not an approved medication.
Phenylephrine
An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
Phenylpropanolamine
A sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy.
Promethazine
A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
Propylhexedrine
It is used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis.
Pseudoephedrine
An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.
Silver proteinate
A nasal decongestant and antiseptic of the nasal and ear canals.
No drug targets
Sodium chloride
An ingredient found in a variety of nutritional products as a source of electrolytes and water.
No drug targets
Synthetic camphor
Not Annotated
No drug targets
Tetryzoline
An alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations, as well as alleviate nasal congestion.
Thonzylamine
Thozylamine is indicated for use in the symptomatic control of allergic rhinitis or other upper respiratory allergic symptoms [FDA Label]. It is typically a part of combination over the counter...
Tramazoline
A sympathomimetic indicated for nasal decongestion.
Triprolidine
A sedating antihistamine combined with pseudoephedrine and guaifenesin in various types of cold and allergy medications to relieve allergy symptoms, hay fever and common cold symptoms, and to aid in sleep.
Xylometazoline
A direct-acting alpha-adrenergic agonist used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01693198
Cyanobacteria Allergy in Lake KineretNo drug interventionsdiagnosticNot Availableunknown_status
NCT06024564
Sonu Real-World Use Clinical Study to Treat Moderate to Severe Nasal CongestionNo drug interventionstreatmentNot Availablerecruiting
NCT02275364
Functional Magnetic Resonance Imaging (fMRI) Study of Nasal Strips in Nasal CongestionNo drug interventionsbasic_science4completed
NCT04790487
Chlorpheniramine Maleate Nasal Spray for Chronic Rhinitistreatment2 / 3withdrawn
NCT05247333
Implementation of a Minor Ailment Service in Community Pharmacy PracticeNo drug interventionshealth_services_researchNot Availablecompleted
NCT03105297
To Characterize the Performance of the Nasal Dilator Strip in Lowering Nasal Resistance During Sleep, Promoting Nasal Route Breathing and Reducing the Signs and Symptoms of Sleep Disordered Breathing in a Group of Chronic Nocturnal Nasal Congestion Sufferers Who Report Trouble With Their Sleep.No drug interventionsbasic_science2completed
NCT01122849
Exploratory Subjective Sleep Study of a Prototype Nasal DilatorNo drug interventionstreatment2completed
NCT02113449
Market Potential of Carbon Dioxide Nasal Spraytreatment2completed
NCT04797936
BNO 1030 Extract (Imupret) in the Treatment of Mild Forms of COVID-19No drug interventionstreatment4completed
NCT01354418
Bioequivalence of Single Dose Phenylephrine Extended Release Tablets and Phenylephrine HCl Immediate Release Tablets Dosed Every Four Hours (P08340)(COMPLETED)treatment1completed
NCT03549117
A Pivotal Subjective Sleep Study of a Nasal Dilator (Breathe Right Tan)No drug interventionstreatment2completed
NCT02601235
Efficacy and Safety of Pediatric Drugs in Nasal Congestiontreatment3completed
NCT03549130
A Pivotal Study to Assess the Effectiveness of Nasal Dilator (Breathe Right Nasal Strips)No drug interventionstreatment2completed
NCT01448057
Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flutreatment3completed
NCT00648973
To Determine if Diphenhydramine Works for Nasal Congestion at Two Different Dosestreatment4completed
NCT00958776
A Study to Evaluate the Efficacy and Safety of IV Peramivir in Addition to Standard of Care Compared to Standard of Care Alone in Adults and Adolescents Who Are Hospitalized Due to Influenzatreatment3terminated
NCT06323304
Efficacy and Safety of Auricular Acupressure in Treating Allergic RhinitisNo drug interventionstreatmentNot Availablerecruiting
NCT03906968
The Safety and Efficacy of a SinuSonic InterventionNo drug interventionstreatmentNot Availablecompleted
NCT03399721
Investigation of Kinetic Oscillation Stimulation by the Chordate System S101 in the Treatment of Non Allergic RhinitisNo drug interventionstreatmentNot Availablecompleted
NCT00665977
Effect of Heated Humidity With Thermosmartâ„¢ Compared to an Intranasal Steroid in Improving Compliance and Nasal Symptoms in Patients Using Continuous Positive Airway PressureNo drug interventionstreatment3completed
NCT02100605
Study on Hypertonic Saline Nasal SprayNo drug interventionstreatmentNot Availablecompleted
NCT01199497
Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute RhinitisNo drug interventionstreatment3withdrawn
NCT05159271
Efficacy and Safety of Azeol Nasal Spray Versus Placebo in the Treatment of Early Symptoms of Common Cold in AdultsNo drug interventionstreatmentNot Availablecompleted
NCT05843071
PMCF Study to Evaluate Performance and Safety of "NASAL SPRAYS " Used to Relieve Nasal Congestion and DrynessNo drug interventionstreatmentNot Availablecompleted
NCT00662337
Bioequivalence Between Two Oral Formulations of Diphenhydramine Hydrochloridebasic_science1completed
NCT03439436
A Study to Compare Two Formulations of Xylometazoline/Dexpanthenol Nasal Spray for the Treatment of Nasal Congestion.No drug interventionstreatment3completed
NCT00829634
Steady State Kinetics of l-Methamphetamine and Validation of Sensitivity of Dose Estimationbasic_scienceNot Availablecompleted
NCT00957996
Safety Study of IV Peramivir in Hospitalized Subjects With Confirmed or Suspected Influenzatreatment3completed
NCT04910139
A User Study of the Soniflow System for Nasal Congestion ReliefNo drug interventionstreatmentNot Availablecompleted
NCT05244148
Two Seawater-based Formulations for Relief of Nasal Congestion in Paediatric SubjectsNo drug interventionstreatmentNot Availablerecruiting
NCT01129765
Home Usability of a Nasal Lavage System in ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT05365789
A Nasal Spray for Relief of Nasal Congestion in Infants and Toddlers With Common ColdNo drug interventionstreatmentNot Availablecompleted
NCT00378144
Efficacy and Safety of Sinutab on Subjects in the Setting of a Common ColdNo drug interventionstreatment4completed