Non-STEMI Acute Coronary Syndrome (DBCOND0042593)

Identifiers

Synonyms

Non-ST-segment Acute Coronary Syndrome / Non ST-elevation Acute Coronary Syndromes / Non-ST-elevation Acute Coronary Syndromes / Non-ST Elevation Acute Coronary Syndrome / Non–ST-elevation acute coronary syndrome / Non-ST-elevation Acute Coronary Syndrome / Non-ST Segment Elevation Acute Coronary Syndrome / Non ST Elevation Acute Coronary Syndromes / Non ST Segment Elevation Acute Coronary Syndrome / Acute Coronary Syndrome (ACS) caused by Non ST Segment Elevation Myocardial Infarction (NSTEMI) / Acute Coronary Syndrome / Acute coronary syndrome (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Bivalirudin	A direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention.	Prothrombintarget Myeloperoxidaseenzyme
Captopril	An ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy.	Angiotensin-converting enzymetarget Albumincarrier 72 kDa type IV collagenasetarget Matrix metalloproteinase-9target ATP-dependent translocase ABCB1transporter Solute carrier family 15 member 1transporter Solute carrier family 22 member 6transporter Leukotriene A-4 hydrolasetarget B1 bradykinin receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01962428	Different LD of Ticagrelor for Antiplatelet Effect in Patients With Non-ST-segment Elevation ACS Undergoing PCI	Ticagrelor	treatment	4	completed
NCT06255678	Angio-based Final Functional Effect of PCI	No drug interventions	Not Available	Not Available	recruiting
NCT02578537	COmparison of the Pharmacodynamics and Pharmacokinetics Ticagrelor Versus Clopidogrel in Patients With CKD and NSTE-ACS	Clopidogrel Ticagrelor	treatment	4	unknown_status
NCT04400500	Differential Diagnosis and Risk Stratification in Patients With Suspected NSTEACS	No drug interventions	Not Available	Not Available	completed
NCT05779059	Prasugrel Or Ticagrelor De-escalation in NSTE-ACS	Prasugrel Ticagrelor	treatment	3	not_yet_recruiting
NCT05202041	Non-IRA Functional Evaluation With AccuFFRangio in NSTE-ACS	No drug interventions	treatment	Not Available	unknown_status
NCT06197724	MCG for Identification of Myocardial Ischemia in Suspected NSTE-ACS Patients	No drug interventions	Not Available	Not Available	recruiting
NCT05117866	Acetyl Salicylic Elimination Trial JAPAN: The ASET JAPAN Pilot Study	Prasugrel	treatment	Not Available	active_not_recruiting
NCT03863327	EKG Criteria and Identification of Acute Coronary Occlusion	No drug interventions	Not Available	Not Available	unknown_status
NCT05125276	Less Bleeding by Omitting Aspirin in Non-ST-segment Elevation Acute Coronary Syndrome Patients	Acetylsalicylic acid	treatment	4	recruiting
NCT03300167	Study of the Vascular Response to Percutaneous Coronary Intervention in Patients With Non-ST-elevation Acute Coronary Syndromes Using Intravascular Blood Sampling	No drug interventions	device_feasibility	Not Available	withdrawn
NCT02415803	Safety and Efficacy of Low-Dose Ticagrelor in Chinese Patients With NSTE-ACS	Clopidogrel Ticagrelor	treatment	3	unknown_status
NCT02892903	In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes?	No drug interventions	diagnostic	Not Available	unknown_status
NCT06096909	Early Initiation of Tafolecimab for Patients With Acute Coronary Syndromeundergoing Percutaneous Coronary Intervention in Chinese Population	Cholesterol Tafolecimab	treatment	Not Available	not_yet_recruiting
NCT04766437	Optical Coherence Tomography-Guided PCI With Single-Antiplatelet Therapy	Prasugrel Ticagrelor	treatment	2	completed
NCT05250596	COLchicine On-admission to Reduce Inflammation in Acute Coronary Syndrome (COLOR-ACS)	Atorvastatin Colchicine	treatment	2	completed
NCT02071966	Study of Effects of Ticagrelor on Microparticles and Micro-RNA in NSTE-ACS	Clopidogrel Ticagrelor	treatment	4	terminated
NCT02073565	HARMONEE - Japan-USA Harmonized Assessment by Randomized, Multi-Center Study of OrbusNEich's Combo StEnt	No drug interventions	treatment	Not Available	completed
NCT04476173	ANalgesic Efficacy and Safety of MOrphiNe Versus Methoxyflurane in Patients With Acute Myocardial Infarction	Methoxyflurane Morphine	treatment	3	recruiting
NCT06051110	Individual Patient Data Meta-analysis on Prehospital Risk Assessment in Patients Suspected of Non-ST-segment Elevation Acute Coronary Syndrome	No drug interventions	diagnostic	Not Available	recruiting
NCT00842374	Single Center Registry of Non-STEMI Acute Coronary Syndrome Patients Treated With Bivalirudin	No drug interventions	Not Available	Not Available	completed
NCT02748603	Appropriateness of Coronary Angioplasty in PAtients With isCHEmic Heart Disease	No drug interventions	Not Available	Not Available	unknown_status
NCT01660373	Comparison of Antiplatelet Effect of Ticagrelor vs Tirofiban in Patients With Non-ST Elevation Acute Coronary Syndrome	Ticagrelor Tirofiban	treatment	3	unknown_status
NCT02317198	Ticagrelor or Prasugrel Versus Clopidogrel in Elderly Patients With an Acute Coronary Syndrome and a High Bleeding Risk: Optimization of Antiplatelet Treatment in High-risk Elderly	Clopidogrel Prasugrel Ticagrelor	treatment	4	completed
NCT06436092	Japanese Coronary Intervention Using Drug Eluting and Perfusion Therapy for Left Main Disease (JDEPTH-LM Registry)	No drug interventions	Not Available	Not Available	recruiting
NCT02052635	Ticagrelor vs Clopidogrel in Non-ST Elevation Acute Coronary Syndrome Patients Undergoing PCI With Bivalirudin.	Clopidogrel Ticagrelor	treatment	4	terminated
NCT02284503	Exploring Efficacy of Intensive Rosuvastatin Treatment Peri-PCI in Chinese Patients With Non ST-segment Elevated Acute Coronary Syndrome(NSTE-ACS)	Rosuvastatin	treatment	4	unknown_status
NCT01820429	Residual Platelet Activity Despite Aspirin Utilization in Coronary Heart Disease	No drug interventions	Not Available	Not Available	completed
NCT03641898	Intravascular Ultrasound-derived Assessment of Hemodynamically Negative Lesions in NSTEACS Patients	No drug interventions	Not Available	Not Available	recruiting