Myeloperoxidase

BE0001075ProteinHumansMPO

Peroxidase that plays a central role in the host defense system of polymorphonuclear leukocytes by mediating both (1) formation of neutrophil extracellular trap (NETs) and (2) microbicidal activity (PubMed:16125131, PubMed:17438335, PubMed:20974672, PubMed:20974816, PubMed:22131345, PubMed:25066128, PubMed:28574339,... It is acted on by 46 drugs in DrugBank.

Gene name
MPO
UniProtKB entry
P05164Swiss-Prot
Cellular location
Lysosome
Residues / weight
745 residues · 83,868 Da
Also known as
1.11.2.2 · MPO

Resolves to

Protein
UniProtP05164UniProt namePERM_HUMAN
Gene
HGNCHGNC:7218NCBI Gene4353GenBank189040GeneCardsMPO
Pharmacology
IUPHAR/GtoPdb2789KEGGhsa:4353
Structure
PDB1CXPPDB1D2VPDB1D5L
Drugs

What you can answer from here — as of September 07, 2019

46DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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9Metabolic reactionsDrug transformations it catalyses, substrate to product
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21GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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118+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Myeloperoxidase, how selective are they, and which programs against it are still in active trials?

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