Gastroesophageal Junction Cancer (DBCOND0043630)

Identifiers

Synonyms
Gastro-esophageal Junction (GEJ) Cancer / Cancer of Esophagogastric Junction / Neoplasm of Cardioesophageal Junction / Gastroesophageal Junction Region (GEJ) Cancer / Gastro-esophageal Junction Cancer / Gastroesophageal Junction (GEJ) Cancer / Esophagogastric Junction Cancer / Gastro-oesophageal Junction Cancer / GE Junction Cancer / Gastroesophageal Junction (GEJ) Cancers / Gastroesophageal-junction Cancer (GEJ) / Gastroesophageal junction cancer / Gastrooesophageal junction cancer / Carcinoma of oesophagus NOS / Carcinoma of oesophagus / Carcinoma of esophagus (disorder) / Carcinoma of esophagus / Oesophageal carcinoma NOS / Oesophageal carcinoma / Esophageal carcinoma NOS / Esophageal carcinoma

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00165464
Taxotere, Cisplatin and Irinotecan (CPT-11) for Esophagogastric CancerNo drug interventionstreatment2completed
NCT02085564
Significance of Peritoneal Washing Cytology Before and After Neoadjuvant Chemotherapy in Patients With Esophagogastric-junction CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT05480384
Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal JunctionNo drug interventionstreatment2recruiting
NCT01774851
A Study of MM-111 and Paclitaxel With Trastuzumab in Patients HER2 Positive Carcinomas of the Distal Esophagus, Gastroesophageal (GE) Junction and Stomachtreatment2terminated
NCT01813253
Phase 3 Study of Nimotuzumab and Irinotecan as Second Line With Advanced or Recurrect Gastric and Gastroesophageal Junction Cancertreatment3terminated
NCT03652077
A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignanciestreatment1completed
NCT05322577
A Study Evaluating Bemarituzumab in Combination With Other Anti-cancer Therapies in Subjects With Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer.basic_science1recruiting
NCT04276493
Anti-HER2 Bispecific Antibody ZW25 Activity in Combination With Chemotherapy With/Without Tislelizumabtreatment1 / 2active_not_recruiting
NCT06411171
Safety and Efficacy of Pembrolizumab in Combination With FLOT About Gastroesophageal Junction Cancer:treatment3not_yet_recruiting
NCT02661971
FLOT vs. FLOT/Ramucirumab for Perioperative Therapy of Gastric or GEJ Cancer (RAMSES)treatment2 / 3completed
NCT01747707
Cisplatin,Docetaxel and S-1 for Advanced Gastric and Gastroesophageal Junction Cancertreatment2unknown_status
NCT02178956
A Study of BBI608 Plus Weekly Paclitaxel to Treat Gastric and Gastro-Esophageal Junction Cancertreatment3completed
NCT04510285
A Single-Arm Pilot Study of Adjuvant Pembrolizumab Plus Trastuzumab in HER2+ Esophagogastric Tumors With Persistent Circulating Tumor DNA Following Curative Resectiontreatment2terminated
NCT06532006
A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancertreatment3not_yet_recruiting
NCT05858736
Safety, PK and Efficacy of AI-061 in Advanced Solid TumorsNo drug interventionstreatment1recruiting
NCT06219941
AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2treatment2recruiting
NCT05447234
TCRx_T Cells for Advanced or Recurrent Gastric/Gastroesophageal Junction Cancer After Failure of First ChemotherapyNo drug interventionstreatment0not_yet_recruiting
NCT02872116
Efficacy Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Against Chemotherapy in Stomach Cancer or Stomach/Esophagus Junction Cancertreatment3completed
NCT03448835
Neoadjuvant Capecitabine, Oxaliplatin, Docetaxel and Atezolizumab in Resectable Gastric and GE-junction Cancer (PANDA)treatment2unknown_status
NCT03526835
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumorstreatment1 / 2recruiting
NCT06558786
Registry for Esophageal and Gastroesophageal Junction CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT05539430
Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic AdenocarcinomaNo drug interventionstreatment1recruiting
NCT02027948
A Nutritional Management Algorithm in Older Patients With Locally Advanced Esophageal CancerNo drug interventionsotherNot Availablecompleted
NCT03925974
KN026 in Patients With HER2 Expressing Gastric/Gastroesophageal Junction Cancertreatment2completed
NCT03221426
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)treatment3active_not_recruiting
NCT03529266
Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage for Esophageal or Junctional Carcinoma.treatment2completed
NCT01576666
Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumorsother1completed
NCT01743365
Clinical Trial of Chemotherapy Combination Cisplatin-Fluorouracil-Afatinib in Patients With Inoperable Gastric Cancertreatment2completed
NCT05187182
CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancertreatment1recruiting
NCT05494060
XELOX Combined With Anlotinib and Penpulimab vs XELOX as Adjuvant Therapy in ctDNA Positive Gastric and Esophagogastric Junction Adenocarcinomatreatment2recruiting
NCT06217991
A Clinical Study of Laparoscopic Proximal Gastrectomy Based on PTST(Parachute-tunnel- Style Technique) Esophagogastric Anastomose.No drug interventionstreatmentNot Availableenrolling_by_invitation
NCT02581462
FLOT vs. FLOT/Herceptin/Pertuzumab for Perioperative Therapy of HER-2 Expressing Gastric or GEJ Cancertreatment2 / 3completed
NCT02538562
Human Epidermal Growth Factor Receptor 2 (HER2) Advanced Gastric Epidemiology Study in KoreaNo drug interventionsNot AvailableNot Availablecompleted
NCT05395780
A Phase 2 Study to Evaluate the Safety and Efficacy of Max-40279-01 in Patients With Advanced Gastric Cancer or Gastroesophageal Junction Cancertreatment2unknown_status
NCT04520867
STRENGTH ExpansionNo drug interventionsNot AvailableNot Availablewithdrawn
NCT06585501
A Study of Treatment Patterns in HER2-positive Unresectable and Advanced Gastric/ Gastroesophageal Junction Cancer in ChinaNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT02501603
Afatinib, Paclitaxel, 2nd Line, Advanced Gastric Cancertreatment2completed
NCT04082364
Combination Margetuximab, Retifanlimab, Tebotelimab, and Chemotherapy Phase 2/3 Trial in HER2+ Gastric/GEJ Cancertreatment2 / 3active_not_recruiting
NCT05919264
FOG-001 in Locally Advanced or Metastatic Solid TumorsNo drug interventionstreatment1 / 2recruiting
NCT04396821
A Trial to Evaluate Safety and Tolerability of TST001 in Advanced or Metastatic Solid Tumorstreatment1 / 2recruiting
NCT04931654
A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancertreatment1 / 2recruiting
NCT06101277
Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG)No drug interventionstreatmentNot Availablerecruiting
NCT06293898
Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid TumorsNo drug interventionstreatment1recruiting
NCT06499298
Retrospective Evaluation of Nivolumab in Adjuvant Esophageal Cancer/Gastroesophageal Junction CancerNot AvailableNot Availablenot_yet_recruiting
NCT04061928
Toripalimab With Preoperative Chemoradiotherapy for LA-EGJtreatment1 / 2unknown_status
NCT05439993
Tepotinib Plus Paclitaxel in MET Amplified or MET Exon 14 Alterated Gastric and GEJ Carcinomatreatment1 / 2recruiting
NCT05608785
Single-center, Multi-cohort Exploratory Phase Ib/II Clinical Study of First-line Treatment of Unresectable Locally Advanced/Advanced Adenocarcinoma of the Stomach or Gastroesophageal Junction Based on Different Genotypestreatment1 / 2not_yet_recruiting
NCT06121700
Radiotherapy + Chemoimmunotherapy Followed by Surgery in Patients With Limited Metastatic Gastric or GEJ Cancertreatment2recruiting
NCT02726399
Phase II Study of Ramucirumab With Chemotherapy in Patients With Metastatic Gastroesophageal Junction and Gastric Cancertreatment2terminated
NCT05233436
PF-07265028 As Single Agent And In Combination With Sasanlimab in Advanced or Metastatic Solid Tumorstreatment1terminated
NCT06447636
Perioperative Surufatinib Plus Sintilimab Combined With Chemotherapy in Gastric/Gastroesophageal Junction Adenocarcinomatreatment2not_yet_recruiting
NCT03941873
A Study to Investigate Sitravatinib as Monotherapy and in Combination With Tislelizumab in Participants With Unresectable Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) or Gastric/Gastroesophageal Junction Cancer (GC/GEJC)treatment1 / 2completed
NCT03847168
KN026 in Patients With HER2 Expressing Breast Cancer and Gastric CancerNo drug interventionstreatment1unknown_status
NCT04882241
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)-China Extensiontreatment3active_not_recruiting
NCT06093425
Combination of TST001, Nivolumab and Chemotherapy as First-line Therapy in Advanced or Metastatic GC/GEJ Adenocarcinomatreatment3not_yet_recruiting
NCT05687357
Tislelizumab in Combination With Pre-operative CRT Versus SOC for Locally Advanced G/GEJ Adenocarcinomatreatment2recruiting
NCT01748773
A Study of the Combination of Oxaliplatin, Capecitabine, and Trastuzumab With Chemoradiotherapy in the Adjuvant Setting in Operated Participants With Human Epidermal Growth Factor Receptor-2 Positive (HER2+) Gastric or Gastroesophageal Junction Cancertreatment2completed
NCT06250894
Neoadjuvant Sintilimab Plus Chemoradiotherapy for Locally Advanced Adenocarcinoma of Esophagogastric JunctionNo drug interventionstreatment2recruiting
NCT00917462
Sorafenib for Patients With Metastatic or Recurrent Esophageal and Gastroesophageal Junction Cancertreatment2completed
NCT06452329
A Study to Evaluate Nivolumab in Patients With Unresectable Advanced/Metastatic Gastric Cancer and Gastroesophageal Junction CancerNot AvailableNot Availableactive_not_recruiting
NCT06346392
AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2treatment3recruiting
NCT03488667
Perioperative mFOLFOX Plus Pembrolizumab in Gastroesophageal Junction (GEJ) and Stomach Adenocarcinomatreatment2active_not_recruiting
NCT02433301
PET/MR-imaging to Differentiate Between Responders and Non-responders Receiving Preoperative ChemotherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT05872295
IKS014 in Advanced Solid Tumors That Express HER2No drug interventionstreatment1recruiting
NCT03957564
Liquid Biopsy in Monitoring the Neoadjuvant Chemotherapy and Operation in Gastric CancerNo drug interventionstreatment2unknown_status
NCT03829345
A Translational Study of Single Agent Olaparib in the Treatment of Advanced Oesophagogastric Cancertreatment2unknown_status
NCT01457846
Efficacy and Safety of AZD4547 Versus Paclitaxel in Patients With Advanced Gastric or Gastro-oesophageal CancerNo drug interventionstreatment2terminated
NCT05009966
Study of SYSA1801 in the Treatment of Claudin( CLDN) 18.2 Positive Advanced Malignant Solid TumorNo drug interventionstreatment1unknown_status
NCT05107674
A Study of NX-1607 in Adults With Advanced Malignanciestreatment1recruiting
NCT05086692
A Beta-only IL-2 ImmunoTherapY Studytreatment1 / 2recruiting
NCT05894824
An Open Label, Single-arm, Multicenter Phase Ib/II Study to Evaluate the Safety and Efficacy of T-Dxd in Combination With Ramucirumab as a 2nd Line in Patients With HER2 Low Gastric or Gastroesophageal Junction (GEJ) Adenocarcinomatreatment1 / 2not_yet_recruiting
NCT06005493
Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid TumorsNo drug interventionstreatment1 / 2recruiting
NCT01077999
Chemoradiation and Panitumumab for Esophageal Cancertreatment2completed
NCT00716157
Incidence and Patterns of Nausea/Vomiting With Combined Chemotherapy and RadiationNo drug interventionsNot AvailableNot Availablecompleted
NCT02359968
PReoperative Chemoradiation (Paclitaxel-carboplatin or FOLFOX) for Resectable Esophageal and Junctional Cancertreatment2completed
NCT05053295
Investigator-initiated Pilot Study to Investigate the Efficacy and Safety of Immuncell-LC in Combination With Nivolumab (Opdivo) in Subjects With Advanced or Recurrent Gastric CancerNo drug interventionstreatmentNot Availableunknown_status
NCT00215514
Adjuvant Chemoradiation Therapy for Gastric or Gastroesophageal Junction Adenocarcinomaprevention0completed
NCT01044511
Quality of Life With Esophageal Stent TrialNo drug interventionssupportive_careNot Availableunknown_status
NCT01084330
Phase II Trial of AUY922 vs. Comparators in Advanced Gastric Cancertreatment2completed
NCT04847466
Immunotherapy Combination: Irradiated PD-L1 CAR-NK Cells Plus Pembrolizumab Plus N-803 for Subjects With Recurrent/Metastatic Gastric or Head and Neck Cancertreatment2recruiting
NCT01248403
A Randomized, Double Blind Study Evaluating Paclitaxel With and Without RAD001 in Patients With Gastric Carcinoma After Prior ChemotherapyNo drug interventionstreatment3completed
NCT02988921
MRI and CT Simulation in the Evaluation of Tumor Response and Target Volume Definition for Esophageal or Esophagogastric Cancer Patients Undergoing ChemoradiotherapyNo drug interventionsdiagnosticNot Availablerecruiting
NCT03139487
A Randomized Phase II Open Label Study to Compare the Safety and Efficacy of Subcutaneous Dalteparin Versus Direct Oral Anticoagulants for Cancer-associated Venous Thromboembolismtreatment2unknown_status
NCT03211377
Chemotherapy for Potentially Resectable Locally Advanced Esophagogastric Junction CarcinomaNo drug interventionsNot AvailableNot Availableunknown_status
NCT04821778
Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancertreatment3recruiting
NCT05259696
Glycan Mediated Immune Regulation With a Bi-Sialidase Fusion Protein (GLIMMER-01)treatment1 / 2active_not_recruiting
NCT04752358
ADP-A2M4CD8 in HLA-A2+ Subjects With MAGE-A4 Positive Esophageal or Esophagogastric Junction Cancers (SURPASS-2)No drug interventionstreatment2terminated
NCT05245760
ChemoRadiation And Tislelizumab for Esophageal/EGJ Cancertreatment2withdrawn
NCT04821843
Neoadjuvant Treatment Modalities in Esophageal Cancertreatment3recruiting
NCT06310473
Neoadjuvant Cadonilimab Plus Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer Trialtreatment2not_yet_recruiting
NCT02979691
Phase II/III Study Comparing Chemoradiotherapy With Radiotherapy in Elderly Patients With Esophageal or Esophagogastric Cancer - 3JECROG P-01No drug interventionstreatment2 / 3completed
NCT05275062
Clinical Trial to Evaluate the Safety and Efficacy of IM92 CAR-T Cells Therapy in Patients With Advanced Gastric or Pancreatic AdenocarcinomaNo drug interventionstreatment0unknown_status
NCT04675138
Development of a Clinical Decision Support System With Artificial Intelligence for Cancer CareNo drug interventionsNot AvailableNot Availablerecruiting
NCT02999295
A Phase 1/2 Study of Ramucirumab Plus Nivolumab in Participants With Gastric or GEJ CancerNo drug interventionstreatment1 / 2completed
NCT00780494
Ph II of Capecitabine, Carboplatin & Bevacizumab for Gastroesophageal Junction & Gastric Carcinomatreatment2completed
NCT00800969
Prospective Evaluation of the Preoperative Lymph Node Staging in Patients With Cancer of the Esophagogastric Junction and StomachNo drug interventionsdiagnostic2withdrawn
NCT03505320
A Study of Zolbetuximab (IMAB362) in Adults With Gastric Cancertreatment2recruiting
NCT03528629
A Study of IMAB362 in Japanese Subjects With Locally Advanced or Metastatic Gastric or Gastro-esophageal Junction (GEJ) AdenocarcinomatreatmentNot Availablecompleted
NCT05891171
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancerstreatment1recruiting