Thiamine Deficiency (DBCOND0055751)

Identifiers

Synonyms

Thiamine deficiency / Thiamine deficiency, unspecified / Thiamine deficiency (disorder) / Vitamin B1 deficiency

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Benfotiamine	A derivative of thiamine thought to be useful in the management of diabetic neuropathy, although evidence is lacking.	No drug targets
Thiamine	A vitamin used to correct vitamin B1 deficiency.	Thiamine pyrophosphokinase 1target Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Organic cation/carnitine transporter 2transporter Cytochrome P450 4B1enzyme Thiamine transporter 1transporter Thiamine transporter 2transporter Thiamine pyrophosphokinase 1enzyme Nucleoside diphosphate phosphatase ENTPD5enzyme Thiamine-triphosphataseenzyme Albumincarrier Pyruvate dehydrogenase E1 componenttarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05480943	Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans	No drug interventions	Not Available	Not Available	completed
NCT04453761	Thiamine Influenced on Substrate Energy Effectiveness in Indonesian Children Undergoing Cardiopulmonary Bypass	Cyanocobalamin Pyridoxine Thiamine	treatment	4	unknown_status
NCT03746106	The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine	Metformin Thiamine Trimethoprim	basic_science	4	completed
NCT05390086	Further Development and Assessment of Tools to Measure Risk Factors for and Treatment of Thiamine Deficiency Disorders	No drug interventions	Not Available	Not Available	completed
NCT03228030	Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial	No drug interventions	treatment	1	completed
NCT03550794	Thiamine as a Renal Protective Agent in Septic Shock	Thiamine	treatment	2	completed
NCT04641104	The Thiamine Administration After Cardiac Surgery Trial	Thiamine	treatment	4	completed
NCT05663164	Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS)	Thiamine	treatment	Not Available	completed
NCT03122678	Thiamine Supplementation in Patients With Septic Shock	D-glucose Thiamine	treatment	1	withdrawn
NCT03616288	Trial of Thiamine Supplementation in Cambodia	No drug interventions	prevention	Not Available	completed
NCT01524315	Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery	Thiamine	supportive_care	4	completed
NCT03626337	Thiamine Responsive Disorders (TRD) Among Infants in Lao PDR	Thiamine	Not Available	Not Available	completed
NCT03263442	High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation	Thiamine	prevention	2	completed
NCT02464865	Thiamin Deficiency in Obese Thai Children	Thiamine	screening	4	completed
NCT06298344	The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease	Thiamine	treatment	0	recruiting
NCT03554668	Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study)	No drug interventions	Not Available	Not Available	completed