NCT01455298
Liver Disease in Adults With Alpha-1 AT Deficiency No drug interventions screening Not Available completed NCT02282527
A Study to Assess Safety and PK of Liquid Alpha₁-Proteinase Inhibitor (Human) in Treating Alpha₁-Antitrypsin Deficiency treatment 2 / 3 completed NCT01213043
Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiency treatment 2 completed NCT03679598
Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency treatment 2 completed NCT05899673
An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease treatment 3 active_not_recruiting NCT06165341
Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis) treatment 3 recruiting NCT06512454
A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems No drug interventions Not Available Not Available recruiting NCT05677971
Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein treatment 3 recruiting NCT05466747
A Study of RYMPHYSIA for Alpha1-Proteinase Inhibitor (A1PI) Therapy in Adults With A1PI Deficiency and Chronic Obstructive Pulmonary Disease (COPD)-Emphysema treatment 4 withdrawn NCT04474197
Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype No drug interventions treatment 2 completed NCT02525861
GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study treatment 3 completed NCT02870309
Safety and Pharmacokinetics of Alpha-1 MP (Alpha1-proteinase Inhibitor (Human), Modified Process) in Participants With Alpha1-Antitrypsin Deficiency treatment 1 / 2 completed NCT02870348
Long-term Safety of Alpha1-Proteinase Inhibitor (Human) in Japanese Subjects With Alpha1 Antitrypsin Deficiency (GTI1401-OLE) treatment 1 / 2 completed NCT00313144
Aralast alpha1-proteinase Inhibitor Surveillance Study treatment 4 terminated NCT02722304
Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency treatment 3 terminated NCT04722887
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency treatment 1 / 2 recruiting NCT01651351
GLASSIA Infusion Rate Study treatment 4 completed NCT04440488
ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study treatment 4 withdrawn NCT00161707
Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficiency treatment 1 / 2 completed NCT00157092
Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency treatment 1 / 2 completed NCT02929940
Liver Disease in Patients With alpha1-antitrypsin Deficiency No drug interventions Not Available Not Available unknown_status NCT02922751
FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE) No drug interventions Not Available Not Available completed NCT04443192
A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers and PiXZ Subjects No drug interventions treatment 1 terminated NCT03823443
COPD Exacerbation Blood and Urine Biomarkers Study No drug interventions Not Available Not Available terminated NCT01974830
AL1TER™: Alpha-1 Therapy, Evaluation, and Research Patient Registry No drug interventions Not Available Not Available completed NCT06622668
A Phase 1/2 Study of NTLA-3001 in Adults with Alpha-1 Antitrypsin Deficiency-Associated Lung Disease No drug interventions treatment 1 / 2 not_yet_recruiting NCT05643495
A Study to Evaluate Efficacy and Safety of VX-864 in Participants With the PiZZ Genotype No drug interventions treatment 2 completed NCT01615484
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability No drug interventions treatment Not Available completed NCT06405633
A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD No drug interventions treatment 1 / 2 recruiting NCT02900183
Safety, Tolerability and Effect of ARC-AAT Injection on Circulating and Intrahepatic Alpha-1 Antitrypsin Levels No drug interventions treatment 2 withdrawn NCT01810458
Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD) Not Available Not Available completed NCT01419158
Prevalence of Alpha-1 Antitrypsin Deficiency in Chronic Obstructive Pulmonary Disease (COPD) No drug interventions Not Available Not Available completed NCT01054339
Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency treatment 2 completed NCT00188825
Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplant treatment 3 completed NCT00005292
Alpha1-antitrypsin Deficiency Registry No drug interventions Not Available Not Available completed NCT03804021
Long-Term Follow-up Study of ADVM-043 No drug interventions Not Available Not Available completed NCT04262284
Respreeza® Self-administration and Learning Program (AmAREtTI Study) No drug interventions Not Available Not Available active_not_recruiting NCT00532805
The Use of High Resolution Chest Computed Tomography in Alpha-1 Antitrypsin Deficiency No drug interventions Not Available Not Available completed NCT02001688
Phase II, Safety and Efficacy Study of Kamada-alpha-1-antitrypsin (AAT) for Inhalation" No drug interventions treatment 2 completed NCT02014415
Alpha-1 Antitrypsin Deficiency Adult Liver Study No drug interventions Not Available Not Available active_not_recruiting NCT03008915
Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency other 2 completed NCT02547532
Microbioma in Sputa From COPD With Alpha-1 Antitrypsin Deficiency No drug interventions Not Available Not Available completed NCT05727800
A Phase 1, First-in-human Study of VX-668 No drug interventions treatment 1 completed NCT01851642
Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs Not Available Not Available recruiting NCT01241942
Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability No drug interventions device_feasibility Not Available terminated NCT03815396
Phase 1 Study to Assess the Safety, PK and PD of INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency treatment 1 completed NCT02810327
Alpha-1 Carrier Genomics Study No drug interventions Not Available Not Available completed NCT06186492
A Phase 1 Research Study to Evaluate Safety, Tolerability, and Pharmacokinetics of WVE-006 in Healthy Participants With Wild-type AAT Expression (RestorAATion-1) No drug interventions treatment 1 recruiting NCT02502201
Environment Effect on Six-Minute Walk Test Performance No drug interventions diagnostic Not Available terminated NCT02363946
A Study of ARC-AAT in Healthy Volunteer Subjects and Patients With Alpha-1 Antitrypsin Deficiency (AATD) treatment 1 terminated NCT00500123
The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study No drug interventions Not Available Not Available recruiting NCT01669421
Effect of Double Dose of Alpha 1-antitrypsin Augmentation Therapy on Lung Inflammation. treatment 2 completed NCT01832220
Genomic Research in Alpha-1 Antitrypsin Deficiency No drug interventions Not Available Not Available completed NCT00884455
Alpha-1 Foundation DNA and Tissue Bank No drug interventions Not Available Not Available enrolling_by_invitation NCT02273349
Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency No drug interventions treatment Not Available withdrawn NCT05178277
Czech AATD Registry No drug interventions Not Available Not Available recruiting NCT01379469
Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency treatment 2 terminated NCT01380626
Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients No drug interventions basic_science Not Available completed NCT04764448
A Study of Belcesiran in Patients With AATLD other 2 terminated NCT05146882
An Extension Study of Belcesiran in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATLD) other 2 withdrawn NCT06505603
PiMZ Longitudinal Cohort (PiMZ Logic) No drug interventions Not Available Not Available not_yet_recruiting NCT06389877
A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD) No drug interventions treatment 1 / 2 recruiting NCT04167345
Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype No drug interventions treatment 2 terminated NCT00242385
Pharmacokinetic Study of ARALAST (Human Alpha1- PI) treatment 1 completed NCT03285100
The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation No drug interventions Not Available Not Available unknown_status NCT03362242
Study of ARO-AAT in Normal Adult Volunteers treatment 1 completed NCT00396006
Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor) treatment 4 completed NCT03946449
Study of Fazirsiran (TAK-999, ARO-AAT) in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD) treatment 2 active_not_recruiting NCT04180319
EARCO REGISTRY. History Of Patients With Alpha-1 Antitrypsin No drug interventions Not Available Not Available recruiting NCT00499941
Alpha-1 Foundation Research Registry No drug interventions Not Available Not Available completed NCT00460096
Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency No drug interventions treatment 2 / 3 completed NCT02168686
Safety Dose Finding Study of ADVM-043 Gene Therapy to Treat Alpha-1 Antitrypsin (A1AT) Deficiency No drug interventions treatment 1 / 2 completed NCT00301366
The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency treatment 3 completed NCT03114020
Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency treatment 2 completed NCT06049082
A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency No drug interventions treatment 1 recruiting NCT03945292
Safety, Tolerability and Pharmacodynamic Effect of Fazirsiran (TAK-999, ARO-AAT) treatment 2 completed NCT00571272
Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC) No drug interventions Not Available Not Available suspended NCT00430768
Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin (AAT) Deficiency treatment 1 completed NCT03385395
Study Comparing Weekly Intravenous Administration of OctaAlpha1 With a Marketed Preparation Glassia® in Subjects With Alpha-1-antitrypsin Deficiency treatment 2 withdrawn NCT04966221
Functional and Structural Lung Imaging in Chronic Obstructive Pulmonary Disease No drug interventions Not Available Not Available unknown_status NCT00263887
Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE) treatment 2 completed NCT03636347
A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. treatment 2 completed NCT00005098
Study of Genotype and Phenotype in Patients With Alpha 1-Antitrypsin Deficiency No drug interventions Not Available Not Available terminated NCT00295061
Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient Adults treatment 3 completed NCT02691611
Epigenetic Regulation of Immunity in Alpha-1 Anti-trypsin Deficiency No drug interventions Not Available Not Available unknown_status NCT01676688
Safety Study of Alfalastin (Human Alpha-1 Antitrypsin) Administered at Home No drug interventions Not Available Not Available completed NCT00067756
4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency? treatment 2 completed NCT04204252
Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD treatment 3 recruiting NCT04157049
Alpha-1 Research Registry No drug interventions Not Available Not Available recruiting NCT04174118
Study of DCR-A1AT in Healthy Adult Volunteers other 1 completed NCT00700934
Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema No drug interventions Not Available Not Available unknown_status NCT05897424
Open Label Extension Study of INBRX-101 in Adults With AATD Emphysema treatment 2 recruiting NCT00377416
Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency No drug interventions treatment 0 completed NCT03039335
The Impact of Delayed Diagnosis of Alpha-1 Antitrypsin Deficiency No drug interventions Not Available Not Available completed NCT03455686
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease No drug interventions basic_science Not Available recruiting NCT03802357
Effects of Different Exercise Training Modalities in Alpha-1 Antitrypsin Deficiency Patients No drug interventions treatment Not Available unknown_status NCT05687474
Baby Detect : Genomic Newborn Screening No drug interventions Not Available Not Available recruiting NCT05579431
A Phase 1, First-in-human Study of VX-634 No drug interventions treatment 1 completed NCT05856331
Study of INBRX-101 Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema treatment 2 recruiting NCT00001462
Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals No drug interventions Not Available Not Available completed NCT05297812
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease No drug interventions Not Available Not Available active_not_recruiting NCT03172455
Early Access Program Using Alpha 1 Antitrypsin Infusion for Patients With Steroid Refractory Acute GvHD After Hematopoietic Stem Cell Transplantation (HSCT) Not Available Not Available no_longer_available