WHIM Syndrome (DBCOND0083276)
Identifiers
- Synonyms
- WHIM syndrome / Warts, hypogammaglobulinemia, infections, and myelokathexis (disorder) / Combined immunodeficiency, unspecified / Combined immunodeficiency / Combined immunodeficiency syndrome / Combined immunity deficiency / Combined immunodeficiencies / Combined immunodeficiency disease (disorder)
Associated Data
- Indicated Drugs and Targets
Drug Description Targets Mavorixafor A CXC chemokine receptor 4 antagonist used to treat WHIM syndrome.- C-X-C chemokine receptor type 4target
- Cytochrome P450 3A4enzyme
- Cytochrome P450 2D6enzyme
- Cytochrome P450 3A5enzyme
- Cytochrome P450 2C19enzyme
- Cytochrome P450 2B6enzyme
- Cytochrome P450 1A2enzyme
- Cytochrome P450 2C8enzyme
- Cytochrome P450 2C9enzyme
- ATP-dependent translocase ABCB1transporter
- Solute carrier family 22 member 2transporter
- Multidrug and toxin extrusion protein 1transporter
- Clinical Trials
Identifier Title Drug(s) Purpose Phase Status NCT03087370 A Retrospective and Prospective Natural History Study of Patients With WHIM Syndrome No drug interventions Not Available Not Available withdrawn NCT03005327 A Dose Determination and Safety Study of X4P-001 (Mavorixafor) in Participants With Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome treatment 2 completed NCT03995108 Efficacy and Safety Study of Mavorixafor in Participants With Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome treatment 3 active_not_recruiting