B-Cell Chronic Lymphocytic Leukemia

Also known as: Lymphocytic Leukemia, Chronic, B-Cell / Lymphocytic Leukemia, Chronic, B Cell / Leukemia, Chronic Lymphocytic, B-Cell / B-cell chronic lymphocytic leukemia (CLL) / B-Cell Chronic Lymphocytic Leukemia (B-CLL) / Leukemia, Lymphocytic, Chronic, B-Cell / Chronic B Cell Lymphocytic Leukemia / Chronic Leukemia, Lymphocytic, B Cell / Chronic lymphocytic leukemia of B-cell type not having achieved remission / Chronic lymphocytic leukemia of B-cell type / B-cell chronic lymphocytic leukaemia / Chronic lymphocytic leukemia / Leukemia lymphocytic chronic / CLL / Chronic lymphoid leukaemia / Lymphoid leukaemia, chronic / Chronic lymphoid leukemia, disease (disorder) / Lymphoid leukemia, chronic / Chronic lymphatic leukaemia / Chronic lymphoid leukemia / Leukaemia lymphocytic chronic / Chronic lymphatic leukemia / Chronic lymphocytic leukaemia NOS / Leukaemias chronic lymphocytic / Chronic lymphocytic leukaemia / Chronic lymphocytic leukemia, morphology (morphologic abnormality)

Drug	Drug Name	Drug Description
DB00087	Alemtuzumab	A monoclonal anti-CD52 antibody used in the treatment of B-cell chronic lymphocytic leukemia and relapsing forms of multiple sclerosis.
DB00028	Human immunoglobulin G	A purified form of human immunoglobulin G and other proteins used to treat immunodeficiency and a wide variety of autoimmune disorders.

Drug	Drug Name	Target	Type
DB00087	Alemtuzumab	CAMPATH-1 antigen	target
DB00087	Alemtuzumab	Low affinity immunoglobulin gamma Fc region receptor III-B	target
DB00087	Alemtuzumab	Low affinity immunoglobulin gamma Fc region receptor III-A	target
DB00087	Alemtuzumab	High affinity immunoglobulin gamma Fc receptor I	target
DB00087	Alemtuzumab	Low affinity immunoglobulin gamma Fc region receptor II-a	target
DB00087	Alemtuzumab	Low affinity immunoglobulin gamma Fc region receptor II-b	target
DB00087	Alemtuzumab	Low affinity immunoglobulin gamma Fc region receptor II-c	target
DB00028	Human immunoglobulin G	Low affinity immunoglobulin gamma Fc region receptor III-B	target
DB00028	Human immunoglobulin G	Low affinity immunoglobulin gamma Fc region receptor III-A	target
DB00028	Human immunoglobulin G	High affinity immunoglobulin gamma Fc receptor I	target
DB00028	Human immunoglobulin G	Low affinity immunoglobulin gamma Fc region receptor II-a	target
DB00028	Human immunoglobulin G	Low affinity immunoglobulin gamma Fc region receptor II-b	target
DB00028	Human immunoglobulin G	Low affinity immunoglobulin gamma Fc region receptor II-c	target
DB00028	Human immunoglobulin G	Putative high affinity immunoglobulin gamma Fc receptor IB	target
DB00028	Human immunoglobulin G	Complement C3	target
DB00028	Human immunoglobulin G	Complement C4-A	target
DB00028	Human immunoglobulin G	Complement C4-B	target
DB00028	Human immunoglobulin G	Complement C5	target

Drug	Drug Name	Phase	Status	Count
DB09053	Ibrutinib	Not Available	Recruiting	1
DB17472	Pirtobrutinib	Not Available	Available	1
DB00041	Aldesleukin	1	Completed	1
DB00087	Alemtuzumab	1	Completed	1
DB05220	Alisertib	1	Completed	1
DB12442	Alvespimycin	1	Terminated	1
DB03496	Alvocidib	1	Completed	1
DB03496	Alvocidib	1	Terminated	1
DB00928	Azacitidine	1	Completed	1
DB17322	BI-836826	1	Completed	2
DB17322	BI-836826	1	Withdrawn	1
DB12359	BIIB021	1	Terminated	1
DB06769	Bendamustine	1	Completed	1
DB06769	Bendamustine	1	Terminated	1
DB01156	Bupropion	1	Completed	1
DB08889	Carfilzomib	1	Completed	1
DB00291	Chlorambucil	1	Terminated	1
DB00531	Cyclophosphamide	1	Active Not Recruiting	1
DB00531	Cyclophosphamide	1	Completed	1
DB00531	Cyclophosphamide	1	Terminated	3
DB00531	Cyclophosphamide	1	Unknown Status	1
DB00004	Denileukin diftitox	1	Withdrawn	1
DB12109	Devimistat	1	Terminated	1
DB12021	Dinaciclib	1	Completed	1
DB15211	Duvortuxizumab	1	Terminated	1
DB15211	Duvortuxizumab	1	Withdrawn	1
DB00199	Erythromycin	1	Completed	1
DB00977	Ethinylestradiol	1	Completed	1
DB00773	Etoposide	1	Terminated	1
DB01073	Fludarabine	1	Active Not Recruiting	1
DB01073	Fludarabine	1	Completed	1
DB01073	Fludarabine	1	Terminated	3
DB01073	Fludarabine	1	Unknown Status	1
DB06185	Forodesine	1	Terminated	1
DB09053	Ibrutinib	1	Active Not Recruiting	1
DB09053	Ibrutinib	1	Completed	4
DB09053	Ibrutinib	1	Withdrawn	1
DB09054	Idelalisib	1	Terminated	1
DB11694	Ilorasertib	1	Completed	1
DB00480	Lenalidomide	1	Completed	3
DB00480	Lenalidomide	1	Terminated	2
DB00367	Levonorgestrel	1	Completed	1
DB00166	Lipoic acid	1	Terminated	1
DB00683	Midazolam	1	Completed	1
DB12191	Obatoclax	1	Terminated	1
DB08935	Obinutuzumab	1	Terminated	1
DB00526	Oxaliplatin	1	Terminated	1
DB17472	Pirtobrutinib	1	Active Not Recruiting	1
DB06809	Plerixafor	1	Completed	1
DB12146	Rigosertib	1	Completed	1
DB00073	Rituximab	1	Completed	4
DB00073	Rituximab	1	Terminated	4
DB11764	Spebrutinib	1	Completed	2
DB06398	Tanespimycin	1	Terminated	1
DB13881	Tisagenlecleucel	1	Completed	1
DB13881	Tisagenlecleucel	1	Unknown Status	1
DB06273	Tocilizumab	1	Terminated	1
DB11581	Venetoclax	1	Withdrawn	1
DB00582	Voriconazole	1	Completed	1
DB06184	AEG35156	1 / 2	Terminated	1
DB00087	Alemtuzumab	1 / 2	Completed	2
DB03496	Alvocidib	1 / 2	Completed	1
DB14857	Avadomide	1 / 2	Completed	1
DB06769	Bendamustine	1 / 2	Completed	2
DB00531	Cyclophosphamide	1 / 2	Active Not Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Completed	1
DB00531	Cyclophosphamide	1 / 2	Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Unknown Status	1
DB12731	Daporinad	1 / 2	Completed	1
DB00997	Doxorubicin	1 / 2	Active Not Recruiting	1
DB11714	Durvalumab	1 / 2	Completed	1
DB00773	Etoposide	1 / 2	Active Not Recruiting	1
DB05076	Fenretinide	1 / 2	Terminated	1
DB01073	Fludarabine	1 / 2	Completed	2
DB01073	Fludarabine	1 / 2	Recruiting	1
DB01073	Fludarabine	1 / 2	Unknown Status	1
DB15670	Gusacitinib	1 / 2	Terminated	1
DB09053	Ibrutinib	1 / 2	Active Not Recruiting	1
DB09053	Ibrutinib	1 / 2	Completed	4
DB09053	Ibrutinib	1 / 2	Recruiting	2
DB09053	Ibrutinib	1 / 2	Unknown Status	1
DB06186	Ipilimumab	1 / 2	Terminated	1
DB00480	Lenalidomide	1 / 2	Active Not Recruiting	1
DB00480	Lenalidomide	1 / 2	Completed	2
DB16582	Lisocabtagene maraleucel	1 / 2	Recruiting	1
DB08935	Obinutuzumab	1 / 2	Completed	1
DB17468	Odetiglucan	1 / 2	Completed	1
DB06650	Ofatumumab	1 / 2	Completed	1
DB00635	Prednisone	1 / 2	Active Not Recruiting	1
DB00073	Rituximab	1 / 2	Active Not Recruiting	1
DB00073	Rituximab	1 / 2	Completed	3
DB00073	Rituximab	1 / 2	Recruiting	1
DB00073	Rituximab	1 / 2	Terminated	1
DB00073	Rituximab	1 / 2	Unknown Status	1
DB08877	Ruxolitinib	1 / 2	Unknown Status	1
DB12636	Samalizumab	1 / 2	Terminated	1
DB14546	Sulfate ion	1 / 2	Active Not Recruiting	1
DB11581	Venetoclax	1 / 2	Recruiting	1
DB00541	Vincristine	1 / 2	Active Not Recruiting	1
DB18403	Zilovertamab	1 / 2	Active Not Recruiting	1
DB18403	Zilovertamab	1 / 2	Recruiting	1
DB00087	Alemtuzumab	2	Completed	5
DB00087	Alemtuzumab	2	Suspended	1
DB00087	Alemtuzumab	2	Terminated	1
DB00087	Alemtuzumab	2	Unknown Status	1
DB03496	Alvocidib	2	Completed	1
DB03496	Alvocidib	2	Terminated	1
DB11851	Bafetinib	2	Completed	1
DB00112	Bevacizumab	2	Completed	1
DB00112	Bevacizumab	2	Withdrawn	1
DB00188	Bortezomib	2	Terminated	1
DB16741	Bortezomib D-mannitol	2	Terminated	1
DB04849	Cediranib	2	Completed	1
DB00531	Cyclophosphamide	2	Completed	5
DB00531	Cyclophosphamide	2	Unknown Status	1
DB00091	Cyclosporine	2	Completed	2
DB12021	Dinaciclib	2	Terminated	1
DB01073	Fludarabine	2	Active Not Recruiting	1
DB01073	Fludarabine	2	Completed	8
DB01073	Fludarabine	2	Withdrawn	1
DB01611	Hydroxychloroquine	2	Terminated	1
DB16196	INVAC-1	2	Terminated	1
DB09053	Ibrutinib	2	Active Not Recruiting	1
DB09053	Ibrutinib	2	Completed	3
DB09053	Ibrutinib	2	Recruiting	1
DB09054	Idelalisib	2	Completed	1
DB14123	Menthol	2	Completed	1
DB00563	Methotrexate	2	Completed	1
DB00959	Methylprednisolone	2	Completed	1
DB00688	Mycophenolate mofetil	2	Completed	1
DB05764	Navitoclax	2	Withdrawn	1
DB08935	Obinutuzumab	2	Completed	2
DB08935	Obinutuzumab	2	Recruiting	1
DB09037	Pembrolizumab	2	Active Not Recruiting	1
DB00552	Pentostatin	2	Completed	1
DB00552	Pentostatin	2	Unknown Status	1
DB17472	Pirtobrutinib	2	Active Not Recruiting	1
DB06809	Plerixafor	2	Completed	1
DB06638	Quarfloxin	2	Withdrawn	1
DB00073	Rituximab	2	Completed	8
DB00073	Rituximab	2	Unknown Status	1
DB00073	Rituximab	2	Withdrawn	1
DB00020	Sargramostim	2	Completed	1
DB01268	Sunitinib	2	Completed	1
DB00864	Tacrolimus	2	Completed	1
DB15044	Tafasitamab	2	Completed	1
DB06287	Temsirolimus	2	Completed	1
DB15295	Tenalisib	2	Completed	1
DB01041	Thalidomide	2	Completed	1
DB11581	Venetoclax	2	Completed	2
DB11581	Venetoclax	2	Recruiting	2
DB02546	Vorinostat	2	Completed	1
DB15035	Zanubrutinib	2	Recruiting	1
DB00087	Alemtuzumab	3	Completed	2
DB01169	Arsenic trioxide	3	Unknown Status	1
DB06769	Bendamustine	3	Withdrawn	1
DB00291	Chlorambucil	3	Active Not Recruiting	1
DB00291	Chlorambucil	3	Completed	1
DB00531	Cyclophosphamide	3	Completed	1
DB00531	Cyclophosphamide	3	Withdrawn	1
DB01073	Fludarabine	3	Completed	2
DB01073	Fludarabine	3	Withdrawn	1
DB00028	Human immunoglobulin G	3	Recruiting	1
DB09053	Ibrutinib	3	Active Not Recruiting	1
DB09053	Ibrutinib	3	Unknown Status	1
DB09054	Idelalisib	3	Withdrawn	1
DB00480	Lenalidomide	3	Completed	2
DB16582	Lisocabtagene maraleucel	3	Withdrawn	1
DB18866	Nemtabrutinib	3	Recruiting	1
DB08935	Obinutuzumab	3	Active Not Recruiting	1
DB00552	Pentostatin	3	Completed	1
DB00073	Rituximab	3	Completed	1
DB00073	Rituximab	3	Recruiting	1
DB00073	Rituximab	3	Withdrawn	1
DB11581	Venetoclax	3	Active Not Recruiting	1
DB11581	Venetoclax	3	Recruiting	1
DB01073	Fludarabine	4	Completed	1
DB09053	Ibrutinib	4	Completed	1
DB00087	Alemtuzumab	Not Available	Unknown Status	1
DB00188	Bortezomib	Not Available	Completed	1
DB00091	Cyclosporine	Not Available	Completed	1
DB00099	Filgrastim	Not Available	Completed	1
DB01073	Fludarabine	Not Available	Completed	1
DB09053	Ibrutinib	Not Available	Approved for Marketing	1
DB09053	Ibrutinib	Not Available	Completed	3
DB00480	Lenalidomide	Not Available	Terminated	1
DB00688	Mycophenolate mofetil	Not Available	Completed	1
DB00073	Rituximab	Not Available	Completed	1
DB17459	Therapeutic allogeneic lymphocytes	Not Available	Completed	1