Antineoplastic Agents, Alkylating
- Name
- Antineoplastic Agents, Alkylating
- Accession Number
- DBCAT000592
- Description
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
- Drugs
Drug Drug Description Adozelesin Adozelesin is a small molecule drug. Adozelesin has a monoisotopic molecular weight of 502.16 Da. Altretamine An antineoplastic agent used in palliative treatment of persistent or recurrent ovarian cancer. Bendamustine An antineoplastic nitrogen mustard agent used in the treatment of indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy. Bizelesin Bizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific. Busulfan An alkylating agent used to treat chronic myelogenous leukemia. Carboquone Not Annotated Carmustine An alkylating agent used in the treatment of various malignancies, including brain tumours and multiple myeloma, among others. Carzelesin Carzelesin is a small molecule drug. Carzelesin has a monoisotopic molecular weight of 728.25 Da. Chlorambucil A chemotherapy agent used in the management of chronic lymphocytic leukemia and malignant lymphomas. Cyclophosphamide A nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma. Dacarbazine An antineoplastic agent used to treat malignant melanoma and Hodgkin's disease. Dianhydrogalactitol Dianhydrogalactitol has been used in trials studying the treatment of GBM, Glioma, Glioblastoma, Brain Cancer, and Glioblastoma Multiforme. Estramustine An antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting. Estramustine phosphate A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties. Etoglucid Not Annotated Ifosfamide An alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma. Irofulven Investigated for use/treatment in brain cancer, breast cancer, endometrial cancer, liver cancer, lung cancer, ovarian cancer, pancreatic cancer, pediatric indications, prostate cancer, and sarcoma. Lomustine An alkylating agent used as a part of chemotherapeutic regimens for the treatment of primary and metastatic brain tumors as well as refractory or relapsed Hodgkin's disease in addition to surgical and/or radiotherapeutic treatments. Mannomustine Mannomustine is a small molecule drug. The usage of the INN stem '-mustine' in the name indicates that Mannomustine is a antineoplastic, alkylating agent, (β-chloroethyl) amine derivative. Mannomustine has a... Mechlorethamine An antineoplastic agent used to treat Hodgkin's disease, lymphosarcoma, and chronic myelocytic or lymphocytic leukemia. Melphalan An alkylating agent used to treat multiple myeloma, ovarian carcinoma, uveal melanoma with unresectable hepatic metastases, and for high-dose conditioning before hematopoietic stem cell transplant in patients. Melphalan flufenamide A melphalan prodrug used to treat relapsed or refractory multiple myeloma. Minnelide Not Annotated Minnelide free acid Not Annotated Mitobronitol Not Annotated Mitolactol Mitolactol has been used in trials studying the treatment of Brain and Central Nervous System Tumors. Palifosfamide Investigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma. Pipobroman For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia. Prednimustine Prednimustine has been used in trials studying the treatment of Lymphoma. Semustine Not Annotated Streptozocin A nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma. Tallimustine An alkylating agent previously investigated for it's antitumor activity but was stopped due to severe myelotoxicity. Temozolomide An alkylating agent used to treat glioblastoma multiforme and refractory anaplastic astrocytoma. Thiotepa An alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas. Trabectedin An alkylating agent approved for the treatment of unresectable or metastatic soft tissue sarcoma (liposarcoma or leiomyosarcoma). Treosulfan A DNA alkylating agent used in the context of myeloablative conditioning prior to allogeneic hemoatopoietic stem cell transplantation. Tretamine Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers. Triaziquone Not Annotated Triptolide Triptolide has been used in trials studying the treatment of HIV, Crohn's Disease, Intestinal Diseases, Gastrointestinal Diseases, and Digestive System Diseases, among others. Trofosfamide Trofosfamide has been used in trials studying the treatment of Ependymomas, Medulloblastomas, Sarcoma, Soft Tissue, Supratentorial PNETs, and Recurrent Brain Tumors. Uracil mustard Used for its antineoplastic properties. - Drugs & Drug Targets