- Cholinesterase Inhibitors
- Accession Number
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
- ATC Classification
Drug Drug Description Tacrine An anticholinesterase drug used for the management of Alzheimer's disease symptoms. Pyridostigmine A cholinesterase inhibitor used for symptomatic treatment of myasthenia gravis and congenital myasthenic syndromes and to reverse neuromuscular blockade by nondepolarizing muscle relaxants. Galantamine A cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. Isoflurophate For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. Donepezil An acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia. Demecarium For the topical treatment of chronic open-angle glaucoma. Physostigmine A cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. Rivastigmine A cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's. Edrophonium A cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis. Ambenonium A cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis. Neostigmine A cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone. Distigmine A cholinesterase inhibitor indicated in the treatment of neurogenic bladder dysfunction or myasthenia gravis. Malathion A parasympathomimetic organophosphate used to treat head lice. Echothiophate An acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma. 1,10-Phenanthroline Not Available Huperzine A Investigated for use/treatment in alzheimer's disease. Coumaphos This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a... Dichlorvos Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products... Fenthion Fenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is... Metrifonate Metrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate. Methanesulfonyl Fluoride Methanesulfonyl Fluoride has been used in trials studying the treatment of Safety. Paraoxon Not Annotated Ginkgo biloba A herbal supplement found in over-the-counter or unapproved homeopathic products for various health conditions, such as cognitive, neurodegenerative, cardiovascular, and reproductive health disorders. Ipidacrine Not Annotated Gallamine triethiodide A nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation. Tubocurarine Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to... Decamethonium For use as a skeletal muscle relaxant Minaprine For the treatment of depression Mefloquine An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Tyrothricin A topical antibiotic with broad spectrum activity against Gram positive bacteria and some fungal infections. Aprotinin A serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery. Thiotepa An alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas. Mechlorethamine An antineoplastic agent used to treat Hodgkin's disease, lymphosarcoma, and chronic myelocytic or lymphocytic leukemia. Tretamine Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers. Hexafluronium Used as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations. Profenamine An antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Cinchocaine An anesthetic used for local or regional anesthesia. Terbutaline A beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor. Procainamide A medication used to treat life threatening ventricular arrhythmias. Pancuronium A neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Bambuterol A long acting beta2-adrenoceptor agonist for the management of lung diseases associated with bronchospasm. Phenserine For the treatment of Alzheimer's disease (AD). Betaine A methyl group donor used for the treatment of homocystinuria to decrease elevated homocysteine blood levels. Capsaicin A topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. Diethylcarbamazine An anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa. Nizatidine An H2 receptor antagonist used to treat GERD and a variety of ulcers. Pegvisomant A growth hormone receptor antagonist used to treat acromegaly. Perindopril An ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction. Pipecuronium A nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures. Cisplatin A platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Ramipril An ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure. Regramostim Investigated for use/treatment in adverse effects (chemotherapy) and bone marrow transplant. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Ketamine A rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant. Memantine An NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's. Ranitidine A histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis. Acotiamide Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia. Posiphen Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease). Methylphosphinic Acid Not Available Carbaryl A medication used in shampoo to remove lice.
- Drugs & Drug Targets