Cholinesterase Inhibitors
- Name
- Cholinesterase Inhibitors
- Accession Number
- DBCAT000815
- Description
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
- ATC Classification
- Drugs
Drug Drug Description (1R)-menthyl hexyl phosphonate group Not Available (1S)-menthyl hexyl phosphonate group Not Available 1,10-Phenanthroline Not Available 2-(N-morpholino)ethanesulfonic acid Not Available 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE Not Available 9-N-Phenylmethylamino-Tacrine Not Available Acotiamide Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia. Albendazole oxide Not Annotated Allicin Allicin has been used in trials studying the treatment of Follicular Lymphoma. Ambenonium A cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis. Anethole An excipient added to medications for flavouring. Angelica archangelica root Angelica archangelica root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. Aprotinin A serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery. Atracurium A neuromuscular blocker indicated to relax muscles during mechanical ventilation under general anesthesia or intubation. Bambuterol A long acting beta2-adrenoceptor agonist for the management of lung diseases associated with bronchospasm. Benzgalantamine A prodrug of galantamine, a competitive and reversible acetylcholinesterase inhibitor used in the management of mild-to-moderate dementia in patients with Alzheimer's disease. Benzoylecgonine Benzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after... Betaine A methyl group donor used for the treatment of homocystinuria to decrease elevated homocysteine blood levels. Bromofos Bromofos is a small molecule drug. Bromofos has a monoisotopic molecular weight of 363.85 Da. Buntanetap Buntanetap (previously known as Posiphen) is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease). Butyric Acid A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester. Capsaicin A topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. Carbaryl A medication used in shampoo to remove lice. Carbofenotion Carbofenotion is a small molecule drug. Carbofenotion has a monoisotopic molecular weight of 341.97 Da. Chlorogenic Acid Chlorogenic Acid has been used in trials studying the treatment of Advanced Cancer and Impaired Glucose Tolerance. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Cinchocaine An anesthetic used for local or regional anesthesia. Cisplatin A platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Coumaphos This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a... Cryptotanshinone Not Annotated Cythioate Cythioate is a member of the organothiophosphate compounds that is used as an insecticide and anthelmintic. It is mainly used in veterinary as a treatment for fleas. Decamethonium For use as a skeletal muscle relaxant Demecarium For the topical treatment of chronic open-angle glaucoma. Dichlorvos Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products... Diethyl phosphonate Not Available Diethylcarbamazine An anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa. Distigmine A cholinesterase inhibitor indicated in the treatment of neurogenic bladder dysfunction or myasthenia gravis. DODECANESULFONATE ION Not Available Donepezil An acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia. Echothiophate An acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma. Edrophonium A cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis. Ethyl biscoumacetate Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226) Ethyl dihydrogen phosphate Not Available Ethyl hydrogen diethylamidophosphate Not Available Fenthion Fenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is... Fucose Fucose is under investigation in clinical trial NCT03354533 (Study of ORL-1F (L-fucose) in Patients With Leukocyte Adhesion Deficiency Type II). Galantamine A cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. Gallamine triethiodide A nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation. Ganstigmine Investigated for use/treatment in alzheimer's disease. Ginkgo biloba A herbal supplement found in over-the-counter or unapproved homeopathic products for various health conditions, such as cognitive, neurodegenerative, cardiovascular, and reproductive health disorders. Ginsenosides Dammarane type triterpene saponins based mainly on the aglycones, protopanaxadiol and protopanaxatriol. Hexafluronium Used as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations. Huperzine A Investigated for use/treatment in alzheimer's disease. Ipidacrine Not Annotated Isoflurophate For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. Isoprenaline A catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block. Ketamine A rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant. Lawsonia inermis leaf Lawsonia inermis leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. Malathion A parasympathomimetic organophosphate used to treat head lice. Mechlorethamine An antineoplastic agent used to treat Hodgkin's disease, lymphosarcoma, and chronic myelocytic or lymphocytic leukemia. Mefloquine An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. Memantine An NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's. Meptazinol Not Annotated Methamidophos Methamidophos is under investigation in clinical trial NCT03223753 (Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia in First Remission). Methanesulfonyl Fluoride Methanesulfonyl Fluoride has been used in trials studying the treatment of Safety. Methylphosphinic Acid Not Available Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Metrifonate Metrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate. Meturedepa Meturedepa is a small molecule drug. Meturedepa has a monoisotopic molecular weight of 275.14 Da. Minaprine For the treatment of depression Neostigmine A cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone. Nizatidine An H2 receptor antagonist used to treat GERD and a variety of ulcers. Pancuronium A neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Paraoxon Not Annotated Pegvisomant A growth hormone receptor antagonist used to treat acromegaly. Perindopril An ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction. Phenserine For the treatment of Alzheimer's disease (AD). Physostigmine A cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. Pipecuronium A nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures. Pomegranate Pomegranate is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. Procainamide A medication used to treat life threatening ventricular arrhythmias. Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Profenamine An antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease. Propanidid An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918) Pyridostigmine A cholinesterase inhibitor used for symptomatic treatment of myasthenia gravis and congenital myasthenic syndromes and to reverse neuromuscular blockade by nondepolarizing muscle relaxants. Ramipril An ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure. Ranitidine A histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis. Regramostim Investigated for use/treatment in adverse effects (chemotherapy) and bone marrow transplant. Rivastigmine A cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's. Ronnel Not Annotated Sarsagenin Not Annotated Solasodine Not Available Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Tacrine An anticholinesterase drug used for the management of Alzheimer's disease symptoms. Terbutaline A beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor. Thiotepa An alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas. Tretamine Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Tubocurarine Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to... Tyrothricin A topical antibiotic with broad spectrum activity against Gram positive bacteria and some fungal infections. Vitexin Not Annotated