Cholinergic Agents

Cholinergic Agents
Accession Number

Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.

DrugDrug Description
Botulinum toxin type BA purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea.
Botulinum toxin type AA purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
NicotineA stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
CevimelineA muscarinic agonist with parasympathomimetic activities that is used for the symptomatic treatment of dry mouth in patients with Sjögren's Syndrome.
TrospiumAn antimuscarinic agent used to treat the symptoms of overactive bladder (OAB).
OxyphenoniumFor the treatment of visceral spasms
BenzatropineAn anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia.
IpratropiumAn anticholinergic drug used in the control of symptoms related to bronchospasm in chronic obstructive pulmonary disease (COPD).
TrihexyphenidylAn antispasmodic drug used as an adjunct drug in the management of parkinsonism and as a treatment for extrapyramidal symptoms caused by drugs affecting the central nervous system (CNS).
TacrineFor the palliative treatment of mild to moderate dementia of the Alzheimer's type.
ProcyclidineAn antispasmodic drug used to treat parkinsonism of various types and in the treatment of extrapyramidal symptoms.
ProfenamineAn antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease.
CarbamoylcholineA direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery.
HyoscyamineAn anticholinergic indicated to treat functional gastrointestinal disorders, biliary and renal colic, and acute rhinitis.
Gallamine triethiodideA nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation.
DarifenacinAn M3 muscarinic receptor blocker used to treat urinary incontinence.
Anisotropine methylbromideFor use in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying.
PyridostigmineA cholinesterase inhibitor used to treat myasthenia gravis.
AtropineA muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
MecamylamineA nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension.
PirenzepineAn antimuscarinic agent used to treat peptic ulcers, gastric ulcers, and duodenal ulcers.
GalantamineA cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease.
IsoflurophateFor use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
Atracurium besylateA non-depolarizing neuromuscular blocker used to facilitate endotracheal intubation and relax skeletal muscles during surgery.
PralidoximeA cholinesterase reactivator used to treat organophosphate poisoning.
ScopolamineA belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV).
MalathionA parasympathomimetic organophosphate used to treat head lice.
PropanthelineAn antimuscarinic agent used to treat urinary incontinence, hyperhidrosis, as well as cramps and spasms of the stomach, intestines, and bladder.
DicyclomineAn antimuscarinic agent used to treat IBS.
TropicamideA muscarinic receptor antagonist used to induce mydriasis and cycloplegia for diagnostic procedures.
BiperidenA muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.
DonepezilAn acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia.
QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
MethanthelineFor the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
DemecariumFor the topical treatment of chronic open-angle glaucoma.
DesloratadineA second generation tricyclic antihistamine used to treat seasonal and non seasonal allergic rhinitis, pruritus, and urticaria.
CyclopentolateAn anticholinergic used to cause mydriasis and cycloplegia for diagnostic testing.
PhysostigmineA cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity.
GlycopyrroniumAn anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.
RivastigmineA cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's.
EdrophoniumA cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis.
BethanecholA muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention.
TolterodineA muscarinic receptor antagonist used to treat overactive bladder with urinary incontinence, urgency, and frequency.
EchothiophateAn acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
PilocarpineA muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy.
PentoliniumUsed to produce controlled hypotension during surgical procedures and in hypertensive crises.
TrimethaphanFor the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies.
AmbenoniumA cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis.
OrphenadrineA muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort.
TubocurarineTubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to...
VareniclineA partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation.
PancuroniumA neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
PipecuroniumA nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures.
VecuroniumA nondepolarizing neuromuscular blocking agent used to relax muscles or as an adjunct in general anesthesia during surgical procedures.
NeostigmineA cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone.
TiotropiumA long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).
SolifenacinA muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder.
1,10-PhenanthrolineNot Available
AcetylcholineA parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.
ArecolineAn alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the...
Huperzine AInvestigated for use/treatment in alzheimer's disease.
LobelineInvestigated for use/treatment in addictions.
GTS-21Investigated for use/treatment in alzheimer's disease and schizophrenia and schizoaffective disorders.
FesoterodineAn antimuscarinic agent used in the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.
MethacholineA parasympathomimetic bronchoconstrictor used to diagnose bronchial hyperreactivity in subjects who do not have clinically apparent asthma.
EpibatidineNot Available
HexamethoniumA nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been...
DexetimideA muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
ChlorphenoxamineChlorphenoxamine is marketed under the name Phenoxene. It is an antihistamine and anticholinergic used to treat itching as well as for its antiparkinsonian effect.
BenactyzineBenactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety. Benactyzine is no longer widely used in medicine, although it is still a...
ButylscopolamineAn antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain.
CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...
FenthionFenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is...
ImidaclopridImidacloprid is a neonicotinoid, which is a class of neuro-active insecticides modeled after nicotine. Imidacloprid is a patented chemical, Imidacloprid is manufactured by Bayer Cropscience (part of Bayer AG) and...
MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.
PropiverineAn antimuscarinic agent used to treat urinary incontinence or increased urinary frequency or urgency.
Methanesulfonyl FluorideMethanesulfonyl Fluoride has been used in trials studying the treatment of Safety.
AtracuriumNot Annotated
PhenglutarimideNot Annotated
ParaoxonNot Annotated
OtiloniumNot Annotated
EmeproniumNot Annotated
GallamineNot Annotated
BornaprineNot Annotated
AlcuroniumA non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.
DistigmineDistigmine is a parasympathomimetic agent with a longer duration of action and enhanced drug accumulation compared to DB00545 and DB01400. It is an anticholinergic drug and long-acting reversible carbamate cholinesterase...
ObidoximeNot Annotated
MivacuriumA short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation.
XanomelineXanomeline is under investigation in clinical trial NCT02831231 (Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium).
HexafluroniumUsed as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations.
PhenserineFor the treatment of Alzheimer's disease (AD).
NGX267Investigated for use/treatment in alzheimer's disease and schizophrenia and schizoaffective disorders.
AcotiamideAcotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia.
PosiphenPosiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).
CarbarylNot Annotated
Drugs & Drug Targets
Botulinum toxin type BVesicle-associated membrane protein 1target
Botulinum toxin type BVesicle-associated membrane protein 2target
Botulinum toxin type BSynaptotagmin-2target
Botulinum toxin type ASynaptosomal-associated protein 25target
Botulinum toxin type ARho-related GTP-binding protein RhoBtarget
NicotineNeuronal acetylcholine receptor subunit alpha-2target
NicotineNeuronal acetylcholine receptor subunit beta-2target
NicotineNeuronal acetylcholine receptor subunit alpha-7target
NicotineNeuronal acetylcholine receptor subunit alpha-4target
NicotineNeuronal acetylcholine receptor subunit alpha-10target
NicotineNeuronal acetylcholine receptor subunit alpha-9target
NicotineCytochrome P450 2A6enzyme
NicotineCytochrome P450 2E1enzyme
NicotineCytochrome P450 2A13enzyme
NicotineCytochrome P450 2B6enzyme
NicotineNeuronal acetylcholine receptor subunit beta-4target
NicotineNeuronal acetylcholine receptor subunit alpha-3target
NicotineNeuronal acetylcholine receptor subunit alpha-5target
NicotineNeuronal acetylcholine receptor subunit alpha-6target
NicotineNeuronal acetylcholine receptor subunit beta-3target
NicotineSolute carrier family 22 member 2transporter
NicotineSolute carrier family 22 member 1transporter
NicotineSolute carrier family 22 member 3transporter
NicotineSolute carrier family 22 member 5transporter
NicotineSolute carrier family 22 member 4transporter
NicotineCytochrome P450 1A1enzyme
NicotineCytochrome P450 1A2enzyme
NicotineCytochrome P450 2C19enzyme
NicotineCytochrome P450 2C8enzyme
NicotineCytochrome P450 2C9enzyme
NicotineCytochrome P450 2D6enzyme
NicotineCytochrome P450 3A4enzyme
NicotineAmine oxidase [flavin-containing] Aenzyme
NicotineAmine oxidase [flavin-containing] Benzyme
NicotineCytochrome P450 19A1target
NicotineCholine O-acetyltransferasetarget
CevimelineMuscarinic acetylcholine receptor M1target
CevimelineMuscarinic acetylcholine receptor M3target
CevimelineCytochrome P450 3A4enzyme
CevimelineCytochrome P450 2D6enzyme
CevimelineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
TrospiumMuscarinic acetylcholine receptor M1target
TrospiumCytochrome P450 2D6enzyme
TrospiumMuscarinic acetylcholine receptor M3target
OxyphenoniumMuscarinic acetylcholine receptor M1target
BenzatropineMuscarinic acetylcholine receptor M1target
BenzatropineSodium-dependent dopamine transportertarget
BenzatropineHistamine H1 receptortarget
BenzatropineSerum albumincarrier
BenzatropineSodium-dependent serotonin transportertarget
BenzatropineSodium-dependent noradrenaline transportertarget
IpratropiumMuscarinic acetylcholine receptor M1target
IpratropiumMuscarinic acetylcholine receptor M2target
IpratropiumMuscarinic acetylcholine receptor M3target
IpratropiumSolute carrier family 22 member 5transporter
IpratropiumSolute carrier family 22 member 4transporter
IpratropiumSerum albumincarrier
Ipratropiumalpha1-acid glycoproteincarrier
TrihexyphenidylMuscarinic acetylcholine receptor M1target
TrihexyphenidylMuscarinic acetylcholine receptor M2target
TrihexyphenidylMuscarinic acetylcholine receptor M3target
TrihexyphenidylMuscarinic acetylcholine receptor M4target
TrihexyphenidylMuscarinic acetylcholine receptor M5target
TrihexyphenidylSerum albumincarrier
TacrineCytochrome P450 1A2enzyme
TacrineP-glycoprotein 1transporter
TacrineLiver carboxylesterase 1target
ProcyclidineMuscarinic acetylcholine receptor M1target
ProcyclidineMuscarinic acetylcholine receptor M2target
ProcyclidineMuscarinic acetylcholine receptor M4target
ProcyclidineMuscarinic acetylcholine receptor M3target
ProfenamineGlutamate receptor ionotropic, NMDA 3Atarget
ProfenamineMuscarinic acetylcholine receptor M1target
ProfenamineMuscarinic acetylcholine receptor M2target
CarbamoylcholineMuscarinic acetylcholine receptor M1target
CarbamoylcholineMuscarinic acetylcholine receptor M2target
CarbamoylcholineNeuronal acetylcholine receptor subunit alpha-2target
CarbamoylcholineCytosolic phospholipase A2enzyme
CarbamoylcholineMuscarinic acetylcholine receptor M3target
CarbamoylcholineMuscarinic acetylcholine receptor M4target
HyoscyamineMuscarinic acetylcholine receptor M1target
HyoscyamineMuscarinic acetylcholine receptor M2target
HyoscyamineMuscarinic acetylcholine receptor M3target
HyoscyamineMuscarinic acetylcholine receptor M4target
HyoscyamineAdenylate cyclase type 1target
Gallamine triethiodideNeuronal acetylcholine receptor subunit alpha-2target
Gallamine triethiodideMuscarinic acetylcholine receptor M2target
Gallamine triethiodideAcetylcholinesterasetarget
Gallamine triethiodideMuscarinic acetylcholine receptor M1target
Gallamine triethiodideMuscarinic acetylcholine receptor M5target
DarifenacinMuscarinic acetylcholine receptor M3target
DarifenacinCytochrome P450 3A4enzyme
DarifenacinCytochrome P450 2D6enzyme
DarifenacinMuscarinic acetylcholine receptor M1target
DarifenacinMuscarinic acetylcholine receptor M2target
DarifenacinMuscarinic acetylcholine receptor M4target
DarifenacinMuscarinic acetylcholine receptor M5target
Anisotropine methylbromideMuscarinic acetylcholine receptor M1target
Anisotropine methylbromideMuscarinic acetylcholine receptor M2target
Anisotropine methylbromideMuscarinic acetylcholine receptor M3target
PyridostigmineSerum albumintarget
AtropineMuscarinic acetylcholine receptor M2target
AtropineMuscarinic acetylcholine receptor M1target
AtropineMuscarinic acetylcholine receptor M4target
AtropineMuscarinic acetylcholine receptor M5target
AtropineMuscarinic acetylcholine receptor M3target
AtropineGlycine receptor subunit alpha-1target
AtropineNeuronal acetylcholine receptor subunit alpha-4target
AtropineNeuronal acetylcholine receptor subunit beta-2target
AtropineBile salt export pumptransporter
MecamylamineNeuronal acetylcholine receptor subunit alpha-2target
MecamylamineNeuronal acetylcholine receptor subunit alpha-7target
MecamylamineNeuronal acetylcholine receptor subunit alpha-4target
MecamylamineNeuronal acetylcholine receptor subunit beta-2target
PirenzepineMuscarinic acetylcholine receptor M1target
GalantamineCytochrome P450 3A4enzyme
GalantamineCytochrome P450 2D6enzyme
GalantamineP-glycoprotein 1transporter
GalantamineNeuronal acetylcholine receptor subunit alpha-7target
GalantamineMuscle nicotinic acetylcholine receptortarget
IsoflurophateSerum albumincarrier
Atracurium besylateNeuronal acetylcholine receptor subunit alpha-2target
ScopolamineMuscarinic acetylcholine receptor M1target
ScopolamineSucrase-isomaltase, intestinaltarget
ScopolamineMuscarinic acetylcholine receptor M2target
ScopolamineMuscarinic acetylcholine receptor M3target
ScopolamineMuscarinic acetylcholine receptor M4target
ScopolamineMuscarinic acetylcholine receptor M5target
ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
ScopolamineNeuronal acetylcholine receptor subunit beta-2target
ScopolamineCytochrome P450 3A4enzyme
MalathionCytochrome P450 1A2enzyme
MalathionCytochrome P450 2B6enzyme
PropanthelineMuscarinic acetylcholine receptor M1target
DicyclomineMuscarinic acetylcholine receptor M1target
DicyclomineMuscarinic acetylcholine receptor M2target
TropicamideMuscarinic acetylcholine receptor M4target
TropicamideMuscarinic acetylcholine receptor M1target
TropicamideMuscarinic acetylcholine receptor M2target
TropicamideMuscarinic acetylcholine receptor M3target
BiperidenMuscarinic acetylcholine receptor M1target
BiperidenCytochrome P450 2D6enzyme
Donepezil5-hydroxytryptamine receptor 2Atarget
DonepezilCytochrome P450 3A4enzyme
DonepezilCytochrome P450 2D6enzyme
DonepezilCytochrome P450 2C9enzyme
DonepezilNitric oxide synthase, braintarget
DonepezilTumor necrosis factor-inducible gene 6 proteintarget
DonepezilInterleukin-1 betatarget
DonepezilNuclear factor NF-kappa-Btarget
DonepezilATP-binding cassette sub-family G member 2transporter
DonepezilNMDA receptortarget
QuinidineSodium channel protein type 5 subunit alphatarget
QuinidineAlpha-1-acid glycoprotein 1carrier
QuinidinePotassium voltage-gated channel subfamily H member 2target
QuinidinePotassium channel subfamily K member 1target
QuinidinePotassium channel subfamily K member 6target
QuinidineCytochrome P450 1A2enzyme
QuinidineCytochrome P450 2E1enzyme
QuinidineCytochrome P450 1A1enzyme
QuinidineCytochrome P450 2D6enzyme
QuinidineCytochrome P450 3A4enzyme
QuinidineCytochrome P450 3A7enzyme
QuinidineSolute carrier family 22 member 2transporter
QuinidineSolute carrier family 22 member 1transporter
QuinidineSolute carrier family 22 member 5transporter
QuinidineP-glycoprotein 1transporter
QuinidineSolute carrier organic anion transporter family member 1A2transporter
QuinidineSolute carrier family 22 member 8transporter
QuinidineCanalicular multispecific organic anion transporter 1transporter
QuinidineSolute carrier family 22 member 4transporter
QuinidineSolute carrier organic anion transporter family member 1B1transporter
QuinidineCytochrome P450 2B6enzyme
QuinidineCytochrome P450 2C9enzyme
QuinidineAlpha-1A adrenergic receptortarget
QuinidineAlpha-1B adrenergic receptortarget
QuinidineAlpha-1D adrenergic receptortarget
QuinidineBile salt export pumptransporter
QuinidineCytochrome P450 2C8enzyme
QuinidineSerum albumincarrier
MethanthelineMuscarinic acetylcholine receptor M1target
MethanthelineHistamine H2 receptortarget
MethanthelineMuscarinic acetylcholine receptor M2target
MethanthelineMuscarinic acetylcholine receptor M3target
MethanthelineMuscarinic acetylcholine receptor M4target
MethanthelineMuscarinic acetylcholine receptor M5target
DesloratadineHistamine H1 receptortarget
DesloratadineP-glycoprotein 1transporter
CyclopentolateMuscarinic acetylcholine receptor M1target
PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
GlycopyrroniumMuscarinic acetylcholine receptor M1target
GlycopyrroniumMuscarinic acetylcholine receptor M3target
GlycopyrroniumMuscarinic acetylcholine receptor M2target
BethanecholMuscarinic acetylcholine receptor M2target
BethanecholMuscarinic acetylcholine receptor M1target
BethanecholMuscarinic acetylcholine receptor M3target
BethanecholMuscarinic acetylcholine receptor M4target
TolterodineMuscarinic acetylcholine receptor M1target
TolterodineMuscarinic acetylcholine receptor M2target
TolterodineMuscarinic acetylcholine receptor M3target
TolterodineCytochrome P450 2D6enzyme
TolterodineCytochrome P450 3A4enzyme
TolterodineCytochrome P450 2C9enzyme
TolterodineCytochrome P450 2C19enzyme
TolterodineMuscarinic acetylcholine receptor M4target
TolterodineMuscarinic acetylcholine receptor M5target
EchothiophateSerum albumincarrier
PilocarpineMuscarinic acetylcholine receptor M1target
PilocarpineMuscarinic acetylcholine receptor M2target
PilocarpineCytochrome P450 2A6enzyme
PilocarpineMuscarinic acetylcholine receptor M3target
PilocarpineCytochrome P450 3A4enzyme
PilocarpineMuscarinic acetylcholine receptor M4target
PentoliniumNeuronal acetylcholine receptor subunit alpha-10target
PentoliniumNeuronal acetylcholine receptor subunit alpha-3target
PentoliniumNeuronal acetylcholine receptor subunit beta-4target
TrimethaphanNeuronal acetylcholine receptor subunit alpha-10target
OrphenadrineGlutamate receptor ionotropic, NMDA 1target
OrphenadrineGlutamate receptor ionotropic, NMDA 2Dtarget
OrphenadrineGlutamate receptor ionotropic, NMDA 3Btarget
OrphenadrineGlutamate receptor ionotropic, NMDA 3Atarget
OrphenadrineHistamine H1 receptortarget
OrphenadrineCytochrome P450 2B6enzyme
OrphenadrineCytochrome P450 2E1enzyme
OrphenadrineCytochrome P450 3A4enzyme
OrphenadrineSodium-dependent noradrenaline transportertarget
OrphenadrineSodium channel protein type 10 subunit alphatarget
OrphenadrineCytochrome P450 1A2enzyme
OrphenadrineCytochrome P450 2D6enzyme
TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
Tubocurarine5-hydroxytryptamine receptor 3Atarget
TubocurarineSolute carrier family 22 member 1transporter
TubocurarineSolute carrier family 22 member 2transporter
TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
VareniclineNeuronal acetylcholine receptor subunit alpha-4target
VareniclineNeuronal acetylcholine receptor subunit alpha-7target
VareniclineNeuronal acetylcholine receptor subunit alpha-3target
VareniclineNeuronal acetylcholine receptor subunit alpha-6target
VareniclineNeuronal acetylcholine receptor subunit beta-2target
VareniclineSolute carrier family 22 member 2transporter
PancuroniumNeuronal acetylcholine receptor subunit alpha-2target
PancuroniumMuscarinic acetylcholine receptor M2target
PancuroniumMuscarinic acetylcholine receptor M3target
PancuroniumSolute carrier family 22 member 1transporter
PancuroniumSolute carrier family 22 member 2transporter
PipecuroniumNeuronal acetylcholine receptor subunit alpha-2target
PipecuroniumMuscarinic acetylcholine receptor M2target
PipecuroniumMuscarinic acetylcholine receptor M3target
VecuroniumP-glycoprotein 1transporter
VecuroniumNeuronal acetylcholine receptor subunit alpha-2target
TiotropiumMuscarinic acetylcholine receptor M3target
TiotropiumCytochrome P450 2D6enzyme
TiotropiumCytochrome P450 3A4enzyme
TiotropiumMuscarinic acetylcholine receptor M1target
TiotropiumMuscarinic acetylcholine receptor M2target
TiotropiumSolute carrier family 22 member 5transporter
TiotropiumSolute carrier family 22 member 4transporter
TiotropiumMuscarinic acetylcholine receptor M4target
TiotropiumMuscarinic acetylcholine receptor M5target
SolifenacinMuscarinic acetylcholine receptor M3target
SolifenacinMuscarinic acetylcholine receptor M1target
SolifenacinCytochrome P450 3A4enzyme
SolifenacinMuscarinic acetylcholine receptor M2target
SolifenacinMuscarinic acetylcholine receptor M4target
SolifenacinMuscarinic acetylcholine receptor M5target
Solifenacinalpha1-acid glycoproteincarrier
SolifenacinCytochrome P450 1A1enzyme
SolifenacinCytochrome P450 2D6enzyme
1,10-PhenanthrolineMethyl-accepting chemotaxis protein IItarget
1,10-PhenanthrolineMetallo-beta-lactamase L1target
AcetylcholineSolute carrier family 22 member 5transporter
AcetylcholineSolute carrier family 22 member 1transporter
AcetylcholineMuscarinic acetylcholine receptor M1target
AcetylcholineMuscarinic acetylcholine receptor M2target
AcetylcholineMuscarinic acetylcholine receptor M3target
AcetylcholineMuscarinic acetylcholine receptor M4target
AcetylcholineNeuronal acetylcholine receptor subunit alpha-7target
ArecolineMuscarinic acetylcholine receptor M1target
ArecolineMuscarinic acetylcholine receptor M3target
Huperzine AAcetylcholinesterasetarget
LobelineNeuronal acetylcholine receptor subunit alpha-9target
LobelineNeuronal acetylcholine receptor subunit alpha-10target
LobelineNeuronal acetylcholine receptor subunit alpha-7target
GTS-21Neuronal acetylcholine receptor subunit alpha-7target
GTS-21Cytochrome P450 1A2enzyme
GTS-21Cytochrome P450 2E1enzyme
FesoterodineMuscarinic acetylcholine receptor M1target
FesoterodineMuscarinic acetylcholine receptor M3target
FesoterodineCytochrome P450 3A4enzyme
FesoterodineMuscarinic acetylcholine receptor M2target
FesoterodineMuscarinic acetylcholine receptor M4target
FesoterodineMuscarinic acetylcholine receptor M5target
FesoterodineCytochrome P450 2D6enzyme
FesoterodineP-glycoprotein 1transporter
MethacholineMuscarinic acetylcholine receptor M3target
MethacholineMuscarinic acetylcholine receptor M2target
MethacholineMuscarinic acetylcholine receptor M1target
MethacholineMuscarinic acetylcholine receptor M4target
MethacholineMuscarinic acetylcholine receptor M5target
MethacholineSolute carrier family 22 member 5transporter
EpibatidineCHRNA7-FAM7A fusion proteintarget
EpibatidineNeuronal acetylcholine receptor subunit alpha-7target
EpibatidineNeuronal acetylcholine receptor subunit beta-2target
EpibatidineNeuronal acetylcholine receptor subunit alpha-2target
EpibatidineNeuronal acetylcholine receptor subunit alpha-3target
EpibatidineNeuronal acetylcholine receptor subunit alpha-4target
EpibatidineNeuronal acetylcholine receptor subunit beta-4target
HexamethoniumNeuronal acetylcholine receptor subunit alpha-2target
ButylscopolamineMuscarinic acetylcholine receptor M3target
ButylscopolamineMuscarinic acetylcholine receptor M2target
DichlorvosSerum albumincarrier
ImidaclopridCHRNA7-FAM7A fusion proteintarget
PropiverineMuscarinic acetylcholine receptor M1target
PropiverineMuscarinic acetylcholine receptor M2target
PropiverineMuscarinic acetylcholine receptor M3target
PropiverineMuscarinic acetylcholine receptor M4target
PropiverineMuscarinic acetylcholine receptor M5target
PropiverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
PropiverineAlpha-1A adrenergic receptortarget
PropiverineCytochrome P450 3A4enzyme
PropiverineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
PropiverineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
OtiloniumCytochrome P450 3A4enzyme
MivacuriumNeuronal acetylcholine receptor subunit alpha-2target
MivacuriumMuscarinic acetylcholine receptor M2target
MivacuriumMuscarinic acetylcholine receptor M3target
PhenserineAmyloid beta A4 proteintarget
NGX267Muscarinic acetylcholine receptor M1target