In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae.

Article Details

Citation

Williamson R, Hakenbeck R, Tomasz A

In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae.

Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.

PubMed ID
7447421 [ View in PubMed
]
Abstract

The interactions of several beta-lactam antibiotics with the penicillin-binding proteins (PBPs) of Streptococcus pneumoniae have been studied using whole organisms treated with such antibiotics and subsequently with [3H]benzylpenicillin. Differences in chemical structure were shown to cause major and selective changes in the affinities of the beta-lactams for the PBPs Only 4 of the 28 compounds tested induced a specific morphological effect (enlargement of the equatorial region) under the particular conditions tested. In 12 of the 18 beta-lactams studied, a close correlation was found between the minimal inhibitory concentrations and the concentrations required to half-saturate PBP2b. However, such a correlation was no longer apparent when the bacteria were treated with the antibiotics at their minimal inhibitory concentrations. These findings are discussed in the context of various approaches that have been used to identify the growth-inhibitory targets of beta-lactam antibiotics in bacteria.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
AmdinocillinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AmdinocillinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AmdinocillinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AmdinocillinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AmdinocillinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
AmpicillinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AmpicillinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AmpicillinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AmpicillinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AmpicillinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
AzidocillinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AzidocillinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AzidocillinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AzidocillinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
AzidocillinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
CefadroxilPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefadroxilPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefadroxilPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefadroxilPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
CefalotinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefalotinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefalotinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefalotinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefalotinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
CefotaximePenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefotaximePenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefotaximePenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefotaximePenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefoxitinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefoxitinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefoxitinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefoxitinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CefoxitinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
CephalexinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CephalexinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CephalexinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CephalexinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CephalexinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
Cephalosporin CPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
Cephalosporin CPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
Cephalosporin CPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
Cephalosporin CPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
Cephalosporin CPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
CloxacillinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CyclacillinPenicillin binding protein 2aProteinStaphylococcus aureus
Yes
Inhibitor
Details
CyclacillinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
CyclacillinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
DicloxacillinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
DicloxacillinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
DicloxacillinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
DicloxacillinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
DicloxacillinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
HetacillinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
HetacillinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
HetacillinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
HetacillinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
HetacillinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
MeticillinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
MeticillinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
MeticillinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
MeticillinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
MeticillinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
NafcillinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
NafcillinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
NafcillinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
NafcillinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
NafcillinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
OxacillinPenicillin-binding protein 1AProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
OxacillinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
OxacillinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
OxacillinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
OxacillinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details
PiperacillinPenicillin-binding protein 1bProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
PiperacillinPenicillin-binding protein 2aProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
PiperacillinPenicillin-binding protein 2BProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Yes
Inhibitor
Details
PiperacillinPenicillin-binding protein 3ProteinStreptococcus pneumoniae
Yes
Inhibitor
Details