In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae.
Article Details
- CitationCopy to clipboard
Williamson R, Hakenbeck R, Tomasz A
In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae.
Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
- PubMed ID
- 7447421 [ View in PubMed]
- Abstract
The interactions of several beta-lactam antibiotics with the penicillin-binding proteins (PBPs) of Streptococcus pneumoniae have been studied using whole organisms treated with such antibiotics and subsequently with [3H]benzylpenicillin. Differences in chemical structure were shown to cause major and selective changes in the affinities of the beta-lactams for the PBPs Only 4 of the 28 compounds tested induced a specific morphological effect (enlargement of the equatorial region) under the particular conditions tested. In 12 of the 18 beta-lactams studied, a close correlation was found between the minimal inhibitory concentrations and the concentrations required to half-saturate PBP2b. However, such a correlation was no longer apparent when the bacteria were treated with the antibiotics at their minimal inhibitory concentrations. These findings are discussed in the context of various approaches that have been used to identify the growth-inhibitory targets of beta-lactam antibiotics in bacteria.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Amdinocillin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Amdinocillin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Amdinocillin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Amdinocillin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Amdinocillin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Ampicillin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Ampicillin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Ampicillin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Ampicillin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Ampicillin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Azidocillin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Azidocillin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Azidocillin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Azidocillin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Azidocillin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Cefadroxil Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefadroxil Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefadroxil Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefadroxil Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Cefalotin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefalotin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefalotin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefalotin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefalotin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Cefotaxime Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefotaxime Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefotaxime Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefotaxime Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefoxitin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefoxitin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefoxitin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefoxitin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cefoxitin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Cephalexin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cephalexin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cephalexin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cephalexin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cephalexin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Cephalosporin C Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cephalosporin C Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cephalosporin C Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cephalosporin C Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cephalosporin C Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Cloxacillin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cyclacillin Penicillin binding protein 2a Protein Staphylococcus aureus YesInhibitorDetails Cyclacillin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Cyclacillin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Dicloxacillin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Dicloxacillin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Dicloxacillin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Dicloxacillin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Dicloxacillin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Hetacillin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Hetacillin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Hetacillin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Hetacillin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Hetacillin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Meticillin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Meticillin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Meticillin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Meticillin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Meticillin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Nafcillin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Nafcillin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Nafcillin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Nafcillin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Nafcillin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Oxacillin Penicillin-binding protein 1A Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Oxacillin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Oxacillin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Oxacillin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Oxacillin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails Piperacillin Penicillin-binding protein 1b Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Piperacillin Penicillin-binding protein 2a Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Piperacillin Penicillin-binding protein 2B Protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6) YesInhibitorDetails Piperacillin Penicillin-binding protein 3 Protein Streptococcus pneumoniae YesInhibitorDetails