Solute carrier family 22 member 3

BE0003650ProteinHumansSLC22A3

Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10196521, PubMed:10966924, PubMed:12538837, PubMed:17460754, PubMed:20858707). It is acted on by 52 drugs in DrugBank.

Gene name
SLC22A3
UniProtKB entry
O75751Swiss-Prot
Cellular location
Cell membrane
Residues / weight
556 residues · 61,279 Da
Also known as
EMT · EMTH · Extraneuronal monoamine transporter · hOCT3 · OCT3

Resolves to

Protein
UniProtO75751UniProt nameS22A3_HUMAN
Gene
HGNCHGNC:10967NCBI Gene6581GenBank3581982GeneCardsSLC22A3
Pharmacology
IUPHAR/GtoPdb1021KEGGhsa:6581
Structure
PDB7ZH0PDB7ZH6PDB7ZHA
Drugs

What you can answer from here — as of September 07, 2019

52DrugsApproved to experimental, with action, bond type and pharmacological action
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27GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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92+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 22 member 3, how selective are they, and which programs against it are still in active trials?

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