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Caffeine Cardiac Contraction Action Pathway
smpdb.ca/view/SMP0126520Drug actionCaffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. The cardiovascular effects are extensive and can help with headaches, migraines, or other types of pain in certain ci...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1APseudoephedrine Action Pathway
smpdb.ca/view/SMP0125255Drug actionDiacylglycerol activates protain kinase C which activates the voltage-dependent calcium channel, allowing calcium to enter the cell. … This high concentration of calcium in the cytosol attaches to calmodulin which activates Myosin light chain kinase.
Drugs: Ascorbic acid · Norepinephrine · Pseudoephedrine · Dopamine · Calcium · Magnesium cation +1 moreEnzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Remoxipride Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126480Drug actionRemoxipride is an atypical antipsychotic dopamine D2 antagonist. Chronic use upregulates the expression of D2 receptors, while downregulating the expression of D1 and D5 receptors in the prefrontal cortex. This activity may be related to...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Mesoridazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126524Drug actionMesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer and a first generation typical antipsychotic. Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reti...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Thioridazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126560Drug actionThioridazine is a trifluoro-methyl phenothiazine derivative. Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Bromopride Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126582Drug actionBromopride is a substituted benzamide. Bromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation an...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Paliperidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126592Drug actionPaliperidone is the primary active metabolite of risperidone. The two antipsychotics are also metabolized differently, as risperidone is metabolized in the liver mainly by the polymorphic cytochrome P450 2D6 (CYP2D6) to its active metabo...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Dosulepin Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126779Drug actionDosulepin is indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. Dosulepin displays affinity towards α2-adrenoceptors and to a lesser extent, α1-adrenoceptors. Inhibition of ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Granisetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126787Drug actionGranisetron is a selective inhibitor of type 3 serotonergic (5-HT3) receptors. Granisetron has little or no affinity for other serotonin receptors, including 5-HT 1 , 5-HT 1A , 5-HT 1B/C , or 5-HT 2 ; for alpha 1 -, alpha 2 -, or beta-ad...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Quetiapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126799Drug actionQuetiapine is used in the symptomatic treatment of schizophrenia. In addition, it may be used for the management of acute manic or mixed episodes in patients with bipolar I disorder, as a monotherapy or combined with other drugs. It may ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1