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Cabergoline Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126670Drug actionCabergoline stimulates centrally-located dopaminergic D2- and D3-receptors. Cabergoline is a long-acting agonist with a high affinity for D2 receptors. It also exhibits: weak agonist activity (in order of decreasing binding affinities) o...
Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1BQuinagolide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126673Drug actionNewer dopamine receptor agonists such as quinagolide and Cabergoline are shown to effectively inhibit prolactin secretion with improved efficacy over Bromocriptine. These drugs are effective in patients who are intolerant or resistant to...
Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1BEthosuximide Action Pathway
smpdb.ca/view/SMP0126318Drug actionVoltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone … Binds to T-type voltage sensitive calcium channels.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Ethosuximide · Calcium · Magnesium cation +3 moreEnzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1GTrimethadione Action Pathway
smpdb.ca/view/SMP0126340Drug actionDione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Trimethadione · Calcium · Magnesium cation +3 moreEnzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1GCaffeine Cardiac Contraction Action Pathway
smpdb.ca/view/SMP0126520Drug actionCaffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. The cardiovascular effects are extensive and can help with headaches, migraines, or other types of pain in certain ci...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1APseudoephedrine Action Pathway
smpdb.ca/view/SMP0125255Drug actionDiacylglycerol activates protain kinase C which activates the voltage-dependent calcium channel, allowing calcium to enter the cell. … This high concentration of calcium in the cytosol attaches to calmodulin which activates Myosin light chain kinase.
Drugs: Ascorbic acid · Norepinephrine · Pseudoephedrine · Dopamine · Calcium · Magnesium cation +1 moreEnzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Remoxipride Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126480Drug actionRemoxipride is an atypical antipsychotic dopamine D2 antagonist. Chronic use upregulates the expression of D2 receptors, while downregulating the expression of D1 and D5 receptors in the prefrontal cortex. This activity may be related to...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Mesoridazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126524Drug actionMesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer and a first generation typical antipsychotic. Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reti...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Thioridazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126560Drug actionThioridazine is a trifluoro-methyl phenothiazine derivative. Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Bromopride Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126582Drug actionBromopride is a substituted benzamide. Bromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation an...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1