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Granisetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126787Drug actionGranisetron is a selective inhibitor of type 3 serotonergic (5-HT3) receptors. Granisetron has little or no affinity for other serotonin receptors, including 5-HT 1 , 5-HT 1A , 5-HT 1B/C , or 5-HT 2 ; for alpha 1 -, alpha 2 -, or beta-ad...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Quetiapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126799Drug actionQuetiapine is used in the symptomatic treatment of schizophrenia. In addition, it may be used for the management of acute manic or mixed episodes in patients with bipolar I disorder, as a monotherapy or combined with other drugs. It may ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Lorpiprazole Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126822Drug actionLorpiprazole is a serotonin antagonist and reuptake inhibitor thus, its activity is performed by antagonizing the 5-HT2A and the 5-HT2C serotoninergic receptors as well as the alpha1 and alpha2 adrenergic receptors, H1 histaminergic rece...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Cyclobenzaprine Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126845Drug actionCyclobenzaprine is a centrally acting skeletal muscle relaxant structurally related to tricyclic antidepressants. Cyclobenzaprine relieves skeletal muscle spasms of local origin without interfering with muscle function. In preclinical re...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125187Drug actionOnce an action potential arrives at the nerve terminal, calcium channels open, causing the influx of calcium in the cytosol. … Calcium then triggers the release of neurotransmitters stored in synaptic vesicles via exocytosis.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Amitriptyline · Sapropterin · Norepinephrine +5 moreEnzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Methsuximide Action Pathway
smpdb.ca/view/SMP0126331Drug actionVoltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone … It binds to T-type voltage sensitive calcium channels.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1GDonepezil Action Pathway
smpdb.ca/view/SMP0126613Drug actionDonepezil is an acetylcholinesterase inhibitor also known as Adlarity, Aricept and Namzaric, that is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or transdermally, sometimes in combination with mem...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Galantamine Action Pathway (new, revision)
smpdb.ca/view/SMP0126671Drug actionGalantamine is a cholinesterase inhibitor used in the treatment of Alzheimer's disease, specifically to mitigate symptoms of mild to moderate dementia. These symptoms of cognitive loss are due to acetylcholine deficiency, galantamine inh...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Minaprine Acetylcholinesterase Antidepressant Action Pathway
smpdb.ca/view/SMP0126689Drug actionMinaprine is an amino-phenylpyridazine antidepressant. It is indicated in the treatment of various depressive states. Minaprine acts on many targets in the neurons. Firstly, this drug binds as an antagonist to the serotonin type 2 recept...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Metrifonate Action Pathway
smpdb.ca/view/SMP0126725Drug actionMetrifonate is an acetylcholinesterase inhibitor, a prodrug that is non-enzymatically converted into its active form Dichlorvos. While binding to acetylcholinesterase it prevents the breakdown of acetylcholine, allowing the neurotransmit...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1