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Glycerolipid Metabolism
smpdb.ca/view/SMP0000039MetabolicThe glycerolipid metabolism pathway describes the synthesis of glycerolipids such as monoacylglycerols (MAGs), diacylglycerols (DAGs), triacylglycerols (TAGs), phosphatidic acids (PAs), and lysophosphatidic acids (LPAs). The process begi...
Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 moreGalactosemia
smpdb.ca/view/SMP0000182DiseaseGalactosemia (GALT Deficiency; GALT; Galactose-1-Phosphate Uridylyltransferase Deficiency) is a rare genetic disorder caused by a mutation in the GALT gene which codes for galactose-1-phosphate uridylyltransferase. A deficiency in this e...
Nicotine Action Pathway
smpdb.ca/view/SMP0000431Drug actionNicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine recepto...
Ethanol Degradation
smpdb.ca/view/SMP0000449MetabolicEthanol metabolism in humans occurs mainly in the liver, though degradation has also been shown in gastric, pancreatic, and lung tissue. Ethanol degradation occurs via four pathways, three of which are oxidative pathways and are depicted...
Salicylate-Sodium Action Pathway
smpdb.ca/view/SMP0000708Drug actionSalicylate-sodium (also named salsonin or clin) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used for relieving pain and reducing fever. Salicylate-sodium can block prostaglandin synthesis by the action of inhibition of pr...
Drugs: Glutamic acid · Glutathione · Dinoprostone · Calcium · Magnesium cation · Salicylic acid +5 moreChlorphenamine H1-Antihistamine Action
smpdb.ca/view/SMP0056661Drug actionChlorphenamine (chlorpheniramine) is a first-generation alkylamine H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to t...
Disulfiram Aldehyde Dehydrogenase Inhibitor Action Pathway
smpdb.ca/view/SMP0122693Drug actionDisulfiram is a carbamate derivative used to treat chronic alcoholism. It irreversibly inhibits aldehyde dehydrogenase in the mitochondrial matrix which converts acetaldehyde to acetic acid causing an accumulation of acetaldehyde. The hi...
Salicylic Acid COX Action Pathway
smpdb.ca/view/SMP0124590Drug actionSalicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Salicylate's use in rheumatic diseases is due to it's analgesic and anti-inflammatory activity. It targets the prostaglandin G/H synt...
D-Glyceric Aciduria
smpdb.ca/view/SMP0125705DiseaseD-Glyceric aciduria is an extremely rare inherited inborn error of metabolism (IEM) of serine and fructose metabolism. It is an autosomal recessive disorder that is caused by a defect in the D-glycerate kinase (GLYCTK) gene. GLYCTK codes...
Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 moreFamotidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0126789Drug actionFamotidine is a histamine H2 receptor antagonist used to treat gastroesophageal reflux disease and various ulcers. Famotidine displays high selectivity towards H2 histamine receptors compared to other H2 anti-histamines. After being take...
Drugs: ATP · Famotidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate