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Displaying results 11 - 20 of 87 in total
  1. Drug

    Magnesium oxide

    go.drugbank.com/drugs/DB01377
    ApprovedInvestigational

    Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.

    Mixtures: Calcemin SilverCategories: Metal cations, Metal divalent cations
  2. Pathway

    Lidocaine NMDA Anesthetic Action Pathway

    smpdb.ca/view/SMP0126262
    Drug action

    The resultant lidocaine cations are then capable of reversibly binding the sodium channels from the inside, keeping them locked in an open state that prevents nerve depolarization.

    Drugs: Lidocaine · Potassium cation · Calcium
  3. Pathway

    Enalapril Action Pathway

    smpdb.ca/view/SMP0000148
    Drug action

    Enalapril (trade name: Vasotec) belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can also be used in the treatment of conge...

    Drugs: Enalapril · Potassium cation · Zinc
  4. Pathway

    Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126504
    Drug action

    Lidocaine is a local anesthetic used in a wide variety of superficial and invasive procedures. It can be found under the brand names Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-...

    Drugs: Lidocaine · Potassium cation · Calcium · Cyclic adenosine monophosphate
  5. Pathway

    Lidocaine (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000328
    Drug action

    This pathway illustrates the lidocaine targets involved in antiarrhythmic therapy. Contractile activity of cardiac myocytes is elicited via action potentials mediated by a number of ion channel proteins. During rest, or diastole, cells m...

    Drugs: NADH · ATP · Lidocaine · Potassium cation · Calcium · Mesoheme +1 more
  6. Pathway

    Betaine Metabolism

    smpdb.ca/view/SMP0000123
    Metabolic

    Betaine (or trimethylglycine) is similar to choline (trimethylaminoethanol) but differs in choline's terminal carboxylic acid group trimethylglycine is reduced to a hydroxyl group. Betaine is obtained from diet as betaine or compounds co...

    Drugs: Tetrahydrofolic acid · Ademetionine · Choline · Methionine · NADH · ATP +8 more
  7. Pathway

    Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

    smpdb.ca/view/SMP0000321
    Signaling

    Adenosine is thought to play a role in the pathophysiology of asthma. Stimulation of A2B can induce production of interleukin-8 mast cells. The adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cycla...

    Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid
  8. Pathway

    Lidocaine (Local Anaesthetic) Action Pathway

    smpdb.ca/view/SMP0000398
    Drug action

    Lidocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Lidocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated...

    Drugs: NADH · ATP · Lidocaine · Norepinephrine · Dopamine · Potassium cation +3 more
  9. Pathway

    Mercaptopurine Metabolism Pathway

    smpdb.ca/view/SMP0000609
    Drug metabolism

    Mercaptopurine is a purine antimetabolite prodrug that exerts cytotoxic effects via three mechanisms: via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA, inhibition of de novo synthesis ...

    Drugs: Ademetionine · L-Glutamine · Adenosine phosphate · NADH · ATP · Mercaptopurine +5 more
  10. Indication

    Tonsillitis

    go.drugbank.com/conditions/DBCOND0014060
    Drugs: Amylocaine · Benzalkonium · Benzethonium · Benzocaine · Cefapirin · Cefdinir +11 more