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Displaying results 31 - 40 of 2844 in total
  1. Pathway

    Lysophosphatidic Acid LPA2 Signalling

    smpdb.ca/view/SMP0063753
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Lysophosphatidic acid receptor 2
  2. Pathway

    Lysophosphatidic Acid LPA4 Signalling

    smpdb.ca/view/SMP0063756
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Lysophosphatidic acid receptor 4
  3. Pathway

    NAD+ Signalling and Aging

    smpdb.ca/view/SMP0084271
    Signaling

    An interesting link has emerged between NAD+ metabolism, SIRT1, SIRT3, and mitochondrial function. … NR and PARP inhibitors increased life span in worms via activation of the mitochondrial unfolded protein response UPRmt by sir2.1.

    Drugs: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · Nicotinamide · Flavin adenine dinucleotide
  4. Pathway

    Meclofenamic acid Action Pathway

    smpdb.ca/view/SMP0126104
    Drug action

    Meclofenamic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2). … Meclofenamic acid is a nonsteroidal anti-inflammatory (NSAID) with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

    Drugs: Glutathione · Dinoprostone · Meclofenamic acid · Calcium · Mesoheme · Prostaglandin G2 +1 more
  5. Pathway

    Lysophosphatidic Acid LPA5 Signalling

    smpdb.ca/view/SMP0063757
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Lysophosphatidic acid receptor 5
  6. Pathway

    Salicylic Acid Action Pathway

    smpdb.ca/view/SMP0000709
    Drug action

    It can be used to reduce pain and fever. Salicylic acid can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. … Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.

    Drugs: Glutamic acid · Glutathione · Dinoprostone · Salicylic acid · Calcium · Magnesium cation +5 more
    Enzymes: Prostaglandin-H2 D-isomerase
  7. Pathway

    Clorazepic Acid Action Pathway

    smpdb.ca/view/SMP0126122
    Drug action

    Clorazepic acid or clorazepate is a benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. … Some side effects of using clorazepic acid may include dizziness, nervousness, blurred vision, and headache.

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Clorazepic acid · Calcium · Magnesium cation +4 more
    Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2
  8. Pathway

    Methylphosphinic Acid Action Pathway

    smpdb.ca/view/SMP0126733
    Drug action

    Further research needs to be conducted in order to confirm results, safety and confirm the mechanism of action. … Methylphosphinic acid is an experimental drug being tested to be a possible cholinesterase inhibitor, as it appears to inhibit the breakdown of acetylcholine.

    Drugs: Choline · Calcium · Magnesium cation · Methylphosphinic Acid · Acetylcholine · Acetic acid
  9. Pathway

    Taurine and Hypotaurine Metabolism

    smpdb.ca/view/SMP0000021
    Metabolic

    This includes acids such as chenodeoxycholic acid and cholic acid, and in turn the formation of bile salts occurs. … Moreover, this entire process can be catalyzed via bile acid and a special amino acid N-acetyltransferase.

    Drugs: Pyridoxal phosphate · Cysteine · Cysteamine · Iron · Taurine
    Enzymes: Cysteine sulfinic acid decarboxylase
  10. Pathway

    Phenylalanine and Tyrosine Metabolism

    smpdb.ca/view/SMP0000008
    Metabolic

    Fumarylacetoacetate is finally split via fumarylacetoacetate-hydrolase into fumarate (also a metabolite of the citric acid cycle) and acetoacetate (3-ketobutyroate). … This reaction functions both as the first step in tyrosine/phenylalanine catabolism by which the body disposes of excess phenylalanine, and as a source of the amino acid tyrosine.

    Drugs: Pyridoxal phosphate · Phenylalanine · Adenosine phosphate · Tyrosine · Glutamic acid · ATP +11 more
    Enzymes: L-amino-acid oxidase