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Displaying results 41 - 50 of 818 in total
  1. Target

    Voltage-gated Potassium Channels

    go.drugbank.com/bio_entities/BE0009847
    Target

    During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion … When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604).

    Polypeptides: A-type voltage-gated potassium channel KCND1, A-type voltage-gated potassium channel KCND2Synonyms: Shal-type potassium channel KCND1, Minimal potassium channel
  2. Pathway

    Metabolism and Physiological Effects of 4-Hydroxyhippuric Acid

    smpdb.ca/view/SMP0125537
    Metabolic

    ; nuts such as​ cashews, almonds, pistachios; and dairy products such as yogurt, milk, and cheese. … Benzoic acid is present in many fruits, such as apricots, prunes, and berries; many vegetables such as mushrooms (fungus), snap peas, cucumbers, and radishes; spices such as cinnamon, cloves, and allspice

    Drugs: ATP · Calcium · Mesoheme · Benzoic acid · Pyrophosphoric acid
  3. Target

    Potassium channel subfamily T member 1

    go.drugbank.com/bio_entities/BE0015369
    TargetHumans

    Contributes to synaptic development and plasticity (By similarity) … Sodium-activated K(+) channel (PubMed:37494189). Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity).

    Polypeptides: Potassium channel subfamily T member 1Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2
  4. Pathway

    Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine

    smpdb.ca/view/SMP0125530
    Metabolic

    Arginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … In the blood it works as a uremic toxin to cause kidney damage, cardiovascular disease and neurological deficits.

    Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 more
  5. Drug

    Calcium carbonate

    go.drugbank.com/drugs/DB06724
    ApprovedInvestigational

    An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia. … Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions.

    Mixtures: GASCID Suspension (Sodium Alginate + Sodium Bicarbonate + Calcium Carbonate), Calcium Magnesium With Potassium TabCategories: Antacids and Adsorbents, Alimentary Tract and Metabolism
  6. Target

    Potassium channel subfamily T member 2

    go.drugbank.com/bio_entities/BE0015626
    TargetHumans

    Sodium-activated and chloride-activated potassium channel (PubMed:14684870, PubMed:16687497, PubMed:25214519, PubMed:27682982, PubMed:29069600, PubMed:29740868).

    Polypeptides: Potassium channel subfamily T member 2Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1, Sequence like an intermediate conductance potassium channel subunit
  7. Indication

    Hyponatremia

    go.drugbank.com/conditions/DBCOND0003943
    Drugs: Sodium acetate · Sodium chloride
    Synonyms: Low serum sodium, Sodium depletion
  8. Drug

    Cyclothiazide

    go.drugbank.com/drugs/DB00606
    Approved

    As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. … This results in an increase in potassium excretion via the sodium-potassium exchange mechanism.

    Categories: cyclothiazide and potassium, Genito Urinary System and Sex Hormones
  9. Target

    Potassium voltage-gated channel subfamily KQT member 1

    go.drugbank.com/bio_entities/BE0000672
    TargetHumans

    During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion … When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604).

    Polypeptides: Potassium voltage-gated channel subfamily KQT member 1Synonyms: Voltage-gated potassium channel subunit Kv7.1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
  10. Indication

    Hyperkalemia

    go.drugbank.com/conditions/DBCOND0003949
    Drugs: Albuterol · Calcium chloride · Calcium saccharate · Patiromer · Sodium bicarbonate · Sodium zirconium cyclosilicate +1 more
    Synonyms: Potassium overload, Potassium excess