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Tiludronic Acid Action Pathway
smpdb.ca/view/SMP0126351Drug actionTiludronic acid is a first-generation bisphosphonate used to treat Paget's disease, similar to etidronic acid and clodronic acid. … Tiludronic acid has a structure similar to pyrophosphate and due to this can be incorporated into ATP analogues that cannot be hydrolyzed.
Drugs: ATP · Tiludronic acid · Magnesium cation · Dimethylallyl Diphosphate · Geranyl Diphosphate · Pyrophosphoric acid +3 moreMethylphosphinic Acid Action Pathway
smpdb.ca/view/SMP0126733Drug actionMethylphosphinic acid is an experimental drug being tested to be a possible cholinesterase inhibitor, as it appears to inhibit the breakdown of acetylcholine. … Further research needs to be conducted in order to confirm results, safety and confirm the mechanism of action.
Oxidronic acid Drug Metabolism
smpdb.ca/view/SMP0130675MetabolicOxidronic acid passes through the liver and is then excreted from the body mainly through the kidney. … Oxidronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Oxidronic acidEthacrynic Acid Diuretic Action Pathway
smpdb.ca/view/SMP0124515Drug actionEthacrynic acid binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … Ethacrynic acid is a loop diuretic drug, administered orally or intravenously to treat high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.
3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
smpdb.ca/view/SMP0125673Diseaseacid. … Other forms of 3-hydroxyisobutyric aciduria may be caused by a mutation in the gene encoding 3-hydroxyisobutyrate dehydrogenase, which forms (S)-methylmalonic acid semialdehyde from (S)-3-hydroxyisobutyric
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialTiaprofenic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174732MetabolicMetabolites of Tiaprofenic acid are predicted with biotransformer.
Tolfenamic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174765MetabolicMetabolites of Tolfenamic acid are predicted with biotransformer.
Phenylalanine and Tyrosine Metabolism
smpdb.ca/view/SMP0000008MetabolicIt may be (1) incorporated into cellular proteins, (2) converted to phenylpyruvic acid, or (3) converted to tyrosine. … Depicted in this pathway is the conversion of phenylalanine to phenylpyruvate (via amino acid oxidase or tyrosine amino transferase acting on phenylalanine), the incorporation of phenylalanine and/or tyrosine
Drugs: Pyridoxal phosphate · Phenylalanine · Adenosine phosphate · Tyrosine · Glutamic acid · ATP +11 moreEnzymes: L-amino-acid oxidaseArginine and Proline Metabolism
smpdb.ca/view/SMP0000020MetabolicIn particular, the amino acid citrulline is first synthesized from several other amino acids (glutamine, glutamate, and proline) in the mitochondria of the intestinal enterocytes (PMID: 9806879). … The arginine and proline metabolism pathway illustrates the biosynthesis and metabolism of several amino acids including arginine, ornithine, proline, citrulline, and glutamate in mammals.
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreEnzymes: D-amino-acid oxidaseMetabolism and Physiological Effects of N-Formyl-L-Methionine
smpdb.ca/view/SMP0126765MetabolicIt is a proteinogenic amino acid, a N-formyl amino acid and a L-methionine derivative. It is a conjugate acid of a N-formyl-L-methioninate. … N-Formyl-L-methionine belongs to the class of organic compounds known as methionine and derivatives.