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Displaying results 1 - 10 of 2123 in total
  1. Pathway

    Fructose and Mannose Degradation

    smpdb.ca/view/SMP0000064
    Metabolic

    Fructose causes less of an insulin response compared to glucose and thus may be a preferred sugar for diabetics. … Fructose and mannose are monosaccharides that can be found in many foods. Fructose can join with glucose to form sucrose. Mannose can be converted to glucose. Both may be used as food sweeteners.

    Drugs: NADH · ATP · Magnesium cation · Zinc · Sorbitol · D-glyceraldehyde 3-phosphate +5 more
  2. Pathway

    Glycine and Serine Metabolism

    smpdb.ca/view/SMP0000004
    Metabolic

    This pathway describes the synthesis and breakdown of several small amino acids, including glycine, serine, and cysteine. … All of these compounds share common intermediates and almost all can be biosynthesized from one another. Serine and glycine are not essential amino acids and can be synthesized from several routes.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  3. Pathway

    Pantothenate and CoA Biosynthesis

    smpdb.ca/view/SMP0000027
    Metabolic

    Pantothenic acid, pantetheine 4’-phosphate and pantetheine are all found in red blood cells. … It is a precursor of coenzyme A, which is an essential part of many reactions in the body, specifically important in the production of compounds like cholesterol and different fatty acids.

    Drugs: Adenosine phosphate · Cysteine · ATP · Cysteamine · Calcium · Pantothenic acid +3 more
  4. Pathway

    Phenylalanine and Tyrosine Metabolism

    smpdb.ca/view/SMP0000008
    Metabolic

    into polypeptides (via tyrosyl tRNA synthetase and phenylalyl tRNA synthetase) and the conversion of phenylalanine to tyrosine via phenylalanine hydroxylase. … Tyrosine can be converted into L-DOPA, which is further converted into dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline).

    Drugs: Pyridoxal phosphate · Phenylalanine · Adenosine phosphate · Tyrosine · Glutamic acid · ATP +11 more
  5. Pathway

    Metabolism and Physiological Effects of Uridine

    smpdb.ca/view/SMP0124871
    Metabolic

    More specifically, uridine is a nucleoside consisting of uracil and D-ribose and a component of RNA. … L-glutamine is first converted to carbamoyl phosphate then to N-Carbamoyl-L-aspartate and finally to dihydroorotate by the CAD protein (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and

    Drugs: Aspartic acid · L-Glutamine · ATP · Magnesium cation · Zinc · Uridine +3 more
  6. Pathway

    Apoptotic DNA Fragmentation and Tissue Homeostasis

    smpdb.ca/view/SMP0063772
    Signaling

    ICAD and CAD exist in the nucleus in normal cells and is a major endonuclease in apoptosis. Its activation is normally caspase dependent. … EndoG resides in mitochondria in normal cells and travels to the nucleus, where it fragments chromosomal DNA upon activation of apoptosis.

    Drugs: Zinc
  7. Pathway

    Metabolism and Physiological Effects of Xanthine

    smpdb.ca/view/SMP0124865
    Metabolic

    The purines are guanine and adenine. These undergo metabolism in the liver to form xanthine. Adenine forms adenosine through the enzyme purine nucleoside phosphorylase. … Adenosine then reacts with water to form inosine and ammonia using the enzyme adenosine deaminase. Inosine goes on to form hypoxanthine through the enzyme purine nucleoside phosphorylase.

    Drugs: Adenine · Adenosine · Zinc · Xanthine · Guanine · Ribose-1-Phosphate +3 more
  8. Pathway

    Metabolism and Physiological Effects of Xanthosine

    smpdb.ca/view/SMP0124866
    Metabolic

    The purines are guanine and adenine. These undergo metabolism in the liver to form xanthosine. Adenine forms adenosine through the enzyme purine nucleoside phosphorylase. … Xanthosine then enters the blood where it can have detrimental effects on other organs such as the kidney, causing renal failure and the heart causing cardiovascular disease.

    Drugs: Adenine · Adenosine · Zinc · Xanthine · Guanine · Ribose-1-Phosphate +3 more
  9. Pathway

    Metabolism and Physiological Effects of Dimethylglycine

    smpdb.ca/view/SMP0124873
    Metabolic

    Dimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. … Dimethylglycine enters the bloodstream and can cause toxic effects on the cardiovascular system.

    Drugs: Choline · Methionine · NADH · Zinc · N,N-dimethylglycine · Flavin adenine dinucleotide +1 more
  10. Pathway

    2-Hydroxyglutric Aciduria (D and L Form)

    smpdb.ca/view/SMP0000136
    Disease

    A deficiency in this enzyme results in accumulation of L-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; and L-lysine in plasma and spinal fluid. … A deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid.

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more