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Nicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicNicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). NAD+ synthesis occurs either de ...
Disulfiram Action Pathway
smpdb.ca/view/SMP0000429Drug actionDisulfiram is a drug used in the treatment of cocaine addiction and chronic alcoholism. With regards to cocaine addiction, cocaine inhibits dopamine reuptake by blocking dopamine transporter 1 (DAT1). This increases dopamine concentratio...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Adenosine phosphate · Tyrosine +27 moreMevalonate Pathway
smpdb.ca/view/SMP0121055Metabolicions and is catalyzed by 3-hydroxy-3-methylglutaryl-coenzyme A reductase to produce (R)-mevalonate, also producing byproducts CoA and NADP. … Now in the endoplasmic reticulum membrane, 2 farnesyl pyrophosphate molecules with the help of NADPH and a hydrogen ion catalyze with squalene synthase and create squalene.
Drugs: ATP · Magnesium cation · Dimethylallyl Diphosphate · Geranyl Diphosphate · Flavin adenine dinucleotide · Flavin mononucleotide +3 moreFluorouracil Metabolism
smpdb.ca/view/SMP0121111MetabolicFrom this point, fluorouracil can be converted to 5,6-dihydro-5-fluorouracil by dihydropyrimidine dehydrogenase, which adds a hydrogen ion to it. … It consists of a fluorine atom on the 5th carbon of a uracil molecule, and is treated similarly to the uracil during metabolism by the body, but the fluorouracil tends to be absorbed more readily by tumor
Galactosemia
smpdb.ca/view/SMP0000182DiseaseGalactosemia (GALT Deficiency; GALT; Galactose-1-Phosphate Uridylyltransferase Deficiency) is a rare genetic disorder caused by a mutation in the GALT gene which codes for galactose-1-phosphate uridylyltransferase. A deficiency in this e...
Phentermine Action Pathway
smpdb.ca/view/SMP0125178Drug actionPhentermine is an oral sympathomimetic anorectic drug used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity. Phentermine is indicated, alone or in combination with topiramate...
Galactose Metabolism
smpdb.ca/view/SMP0000043MetabolicThis pathway depicts the conversion of galactose into glucose, lactose, and other sugar intermediates that may be used for a range of metabolic process. Dietary sources of galactose are numerous, but some of the primary sources in the hu...
Galactosemia
smpdb.ca/view/SMP0125710DiseaseGalactosemia (GALT Deficiency; GALT; Galactose-1-Phosphate Uridylyltransferase Deficiency) is a rare genetic disorder caused by a mutation in the GALT gene which codes for galactose-1-phosphate uridylyltransferase. A deficiency in this e...
Phentermine Norepinephrine Reuptake transporter Satiety Action Pathway
smpdb.ca/view/SMP0126723Drug actionPhentermine is an amine anorectic agent used in weight reduction in cases of exogenous obesity as an adjunct or alone. It is chemically related to amphetamine. It is thought that the primary way phentermine works is by inducing a reducti...
Neuronal Dopamine Gs Cascade
smpdb.ca/view/SMP0126952PhysiologicalIn some other cases, GPCRs can directly affect the ion channel activity in the plasma membrane, thereby regulating the ion permeability and membrane potential of the membrane. … The G protein is associated with the plasma membrane at the cytoplasmic side, connecting the GPCR to either enzymes or ion channels.