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Glycerol Kinase Deficiency
smpdb.ca/view/SMP0000187DiseaseGlycerol Kinase Deficiency (Hyperglycerolemia; Glyceroluria; GK Deficiency; GKD) is a rare metabolic disease caused by a deficiency in the GK gene which codes for glycerol kinase. A deficiency in this enzyme results in accumulation of gl...
Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 moreDisulfiram Action Pathway
smpdb.ca/view/SMP0000429Drug actionDisulfiram is a drug used in the treatment of cocaine addiction and chronic alcoholism. With regards to cocaine addiction, cocaine inhibits dopamine reuptake by blocking dopamine transporter 1 (DAT1). This increases dopamine concentratio...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Adenosine phosphate · Tyrosine +27 moreD-Glyceric Acidura
smpdb.ca/view/SMP0000529DiseaseD-Glyceric aciduria is an extremely rare inherited inborn error of metabolism (IEM) of serine and fructose metabolism. It is an autosomal recessive disorder that is caused by a defect in the D-glycerate kinase (GLYCTK) gene. GLYCTK codes...
Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 moreSalicylate-Sodium NSAID Action Pathway
smpdb.ca/view/SMP0124630Drug actionSalicylate-sodium is an NSAID which possesses anti-inflammatory, analgesic and antipyretic activity. It targets the prostaglandin G/H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The cyclooxy...
Ethanol GABA Agonist Action Pathway
smpdb.ca/view/SMP0125151Drug actionEthanol, commonly seen in the form of various alcohols as well as hand sanitizer, is a drug that is injected intrathecally. Ethanol's effects are mainly seen in the brain where it binds to many receptors. The main effects are seen by the...
Cocaine metabolism
smpdb.ca/view/SMP0125265MetabolicCocaine is a local anaesthetic used for diagnostic procedures or surgery on or through the nasal cavity. It is administered as a spray in the nose where it enters the blood vessels of the nose and travels through the body. When taken ill...
Magnesium Sulfate Action Pathway
smpdb.ca/view/SMP0126350Drug actionMagnesium sulfate is a drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. It can be found under the brand names Concept Ob, Suprep Bowel Prep Kit, and Tis-U-sol. A small colorless cr...
Glycerin Drug Metabolism
smpdb.ca/view/SMP0130649MetabolicGlycerin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Glycerin passes through the liver and is then excreted from the body mainly through the kidney.
Drugs: GlycerinAvobenzone Predicted Metabolism Pathway
smpdb.ca/view/SMP0174515MetabolicMetabolites of Avobenzone are predicted with biotransformer.
Regulation of Lipolysis
smpdb.ca/view/SMP0573273SignalingAdipocyte lipolysis is a highly regulated metabolic process in which triacylglycerols stored in lipid droplets are enzymatically hydrolyzed to free fatty acids and glycerol to meet systemic energy demands. This multistep cascade is orche...