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Displaying drugs 226 - 250 of 12677 in total

Tepotinib

Tepotinib is a MET tyrosine kinase inhibitor intended to treat a variety of MET-overexpressing solid tumors. It was originally developed in partnership between EMD Serono and the University of Texas M.D. Anderson Cancer Center in 2009 and has since been investigated in the treatment of neuroblastoma, gastric cancers, non-small cell...
Approved
Investigational
Matched Description: … In February 2022, tepotinib was approved for use in Europe.[L42200] ... Anderson Cancer Center in 2009 and has since been investigated in the treatment of neuroblastoma,[A228053 ... critical role, both directly and indirectly, in the growth and proliferation of tumors in which it is …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Proto-Oncogene Proteins c-met, antagonists & inhibitors …

Nisoldipine

Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone...
Approved
Matched Description: … Nisoldipine may be used in alone or in combination with other agents in the management of hypertension ... acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in ... By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Vaborbactam

Vaborbactam is a β-lactamase inhibitor based on a cyclic boronic acid pharmacophore. It has been used in trials investigating the treatment of bacterial infections in subjects with varying degrees of renal insufficiency. In August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the FDA for...
Approved
Investigational
Matched Description: … [A32053] It has been used in trials investigating the treatment of bacterial infections in subjects with ... In August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the …

Trandolapril

Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure...
Approved
Matched Description: … It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. ... be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in ... adjunct treatment for congestive heart failure, and to slow the rate of progression of renal disease in …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …

Perindopril

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to...
Approved
Matched Description: … It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration …
Matched Mixtures name: … PERINDO/IN RAT T 5/1.25 ... PERINDO/IN RAT T 5/1.25 ... PERINDO IN 1A PHA4/1.25MG …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …

Chlorquinaldol

Chlorquinaldol was used historically as a topical antiseptic under the trade name Sterosan. It was marketed in the 1950s as an iodine-free alternative which was also unrelated to sulfa drugs or hormones. Chlorquinaldol is currently approved by the European Medicines Agency as a combination tablet with promestriene for the treatment...
Approved
Matched Description: … [F4549] It was marketed in the 1950s as an iodine-free alternative which was also unrelated to sulfa …
Matched Mixtures name: … NERISONA-C %0,1 + %1 KREM, 10 GR ... NERISONA-C %0,1 + %1 KREM, 30 GR ... NERISONA-C %0,1 + %1 KREM, 15 GR …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …

Levocarnitine

Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.
Approved
Investigational
Matched Description: … It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias …

Clonazepam

A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.[FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being...
Approved
Illicit
Matched Description: … for sale from Roche in the US in 1975,[T469,T472] clonazepam has experienced a storied history in the ... [FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being first patented in 1960 and then released …
Matched Categories: … Heterocyclic Compounds, Fused-Ring …

Becaplermin

Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together...
Approved
Investigational
Matched Categories: … Proto-Oncogene Proteins c-sis …

Ethanol

A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Approved
Matched Description: … the primary ingredient in alcoholic beverages. ... It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as …
Matched Mixtures name: … Alcohol in Dextrose ... C-tizers 99.9 ... Northside Hospital C-Section Mothers …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … H C ... C-000001228-064 ... Malibu C Cur8 Hand Sanitizer …

Imatinib

Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with...
Approved
Matched Description: … kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in ... with a daily dosage of 300 mg or more and typically occurred in the first four weeks of therapy". ... Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Propylhexedrine

Propylhexedrine is an alpha-adrenergic agonist often used in nasal decongestant inhalers. It is used to give temporary relief for nasal congestion from colds, allergic rhinitis, or allergies.
Approved
Matched Description: … Propylhexedrine is an alpha-adrenergic agonist often used in nasal decongestant inhalers. …

Flavin mononucleotide

A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
Approved
Investigational
Matched Description: … It is the principal form in which RIBOFLAVIN is found in cells and tissues. …
Matched Mixtures name: … Supravite C 1000 ... Somarexin and C 1000 ... Beminal With C Fortis Pws …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, 3-Ring ... Heterocyclic Compounds, Fused-Ring …

Phenylpropanolamine

Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.
Approved
Vet approved
Withdrawn
Matched Description: … Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic …
Matched Mixtures name: … Contact C Src ... Dimetapp-C Syr ... Tussaminic C Forte Syrup …

Amylmetacresol

Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections , . Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils . The acute sore throat (pharyngitis)...
Approved
Matched Description: … Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the ... Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat ... The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in …
Matched Mixtures name: … STREPSILS ORANGE WITH VITAMIN C ... STREPSILS ORANGE WITH VITAMIN C ... STREPSILS ORANGE WITH VITAMIN C …

Benzatropine

Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. The generation of...
Approved
Matched Description: … It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the ... the para position in one of the phenyl rings produces an increased potency for dopamine uptake inhibition ... structure-activity relationships proved that benztropine derivatives with the presence of a chlorine substituent in …

Phenyl salicylate

Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in DB00945 ). Phenyl salicylate may...
Approved
Matched Description: … salicylate (found in [DB00945] ). ... Phenyl salicylate is used as a food additive in the USA [L2479]. ... Phenyl salicylate may also be found in some antiseptic agents [L2467]. …
Matched Mixtures name: … Utira-C ... Utira-C ... UR N-C Urinary Antiseptic …

Minoxidil

A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Approved
Investigational
Matched Description: … peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

DL-alpha tocopheryl acetate

Approved
Experimental
Matched Mixtures name: … Zintrexyl-C ... Beta C and E Tab ... Vitamins A, C & E Cap. …

Methocarbamol

Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether. Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of...
Approved
Vet approved
Matched Description: … Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated ... A178450] Methocarbamol tablets and intramuscular injections are prescription medicines indicated in ... [Label,L6268] In Canada, methocarbamol can be sold as an over the counter oral medicine at a lower dose …
Matched Mixtures name: … Robaxisal C 1/4 ... Robaxisal C 1/2 ... Methoxisal-C 1/8 …

Zafirlukast

Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once...
Approved
Investigational
Matched Description: … an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in ... leukotrienes on the CysLT1 receptors, thus reducing constriction of the airways, build-up of mucus in …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …

Taliglucerase alfa

Taliglucerase alfa is the recombinant active form of the human lysosomal enzyme, β-glucocerebrosidase. It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's disease.
Approved
Investigational
Matched Description: … It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's …

Magnesium acetate tetrahydrate

Magnesium acetate tetrahydrate is a hydrated form of anhydrous magnesium acetate salt with the chemical formula of Mg(CH3COO)2 • 4H2O. As a salt form of magnesium, magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble compound. Magnesium is an essential element and second...
Approved
Matched Description: … Magnesium is an essential element and second most abundant cation in the body that plays a key role in ... Magnesium acetate tetrahydrate can be used as an electrolyte supplementation or a reagent in molecular …
Matched Mixtures name: … NUTRIFLEX PERI IN 2000ML TWIN-FLEX ... NUTRIFLEX PLUS IN 1000ML TWIN FLEX ... NUTRIFLEX PLUS IN 2000ML TWIN FLEX …

Turoctocog alfa pegol

Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019. Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Description: … acid 720, and a monoclonal antibody binding C-terminal to this position is used in the purification ... During secretion, some rFVIII molecules are cleaved at the C-terminal of the heavy chain (HC) at amino ... B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus …

Niacin

Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565]
Approved
Investigational
Nutraceutical
Matched Mixtures name: … Virt-C DHA ... Taron-C DHA ... C-B Complex …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Displaying drugs 226 - 250 of 12677 in total