Displaying drugs 2476 - 2500 of 15068 in total
Cerivastatin
On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Canadian market.[A669,L43942]
Approved
Withdrawn
Matched Iupac: … 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid …
Matched Description: … Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew …
Matched Description: … Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew …
Crotalus atrox antivenin
Each year it is estimated there are 45,000 snakebites in the US and 300,000 to 400,000 bites worldwide. About 8000 of these snakebites involve venomous snake species. The majority of people bitten are males and about 50% occur in the age group of 18 to 28 .
Crotalus atrox antivenin...
Approved
Experimental
Matched Description: … Each year it is estimated there are 45,000 snakebites in the US and 300,000 to 400,000 bites worldwide ... isolating the antivenin of interest through fractionation and chromatography techniques. ... The majority of people bitten are males and about 50% occur in the age group of 18 to 28 [F113]. …
Isoeugenol
Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. It is also a significant dermatologic sensitizer and allergen, and as a result has been restricted to 200 p.p.m. since 1998 according to guidelines issued by...
Approved
Experimental
Matched Description: … It is also a significant dermatologic sensitizer and allergen, and as a result has been restricted to ... Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally …
Aluminum oxide
Aluminum oxide has a chemical formula Al2O3. It is amphoteric in nature, and is used in various chemical, industrial and commercial applications. It is considered an indirect additive used in food contact substances by the FDA.
Approved
Matched Description: … It is amphoteric in nature, and is used in various chemical, industrial and commercial applications. …
Fluindione
Fluindione is under investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and Anticoagulating Treatment on a Duration at Least 12-month-old Superior. Fluindione has been investigated for the treatment of Blood Coagulation Disorders.
Approved
Investigational
Matched Description: … investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and …
Matched Categories: … Blood and Blood Forming Organs …
Matched Categories: … Blood and Blood Forming Organs …
Umbralisib
Marginal zone lymphoma is a rare, slowly progressing type of non-Hodgkin lymphoma initially treated with rituximab (an anti-CD20 drug), either alone or in combination with chemotherapy. Unfortunately, many patients experience a relapse or develop resistance to these drugs. Treatment options then become limited, and alternate treatments for the lymphoma are...
Approved
Investigational
Withdrawn
Matched Description: … It was marketed as Ukoniq by TG Therapeutics and has been approved for the treatment of relapsing and ... refractory marginal cell lymphoma and follicular lymphoma in adults. ... Treatment options then become limited, and alternate treatments for the lymphoma are required to control …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Poractant alfa
Poractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada. It is used to treat Respiratory Distress Syndrome (RDS) in premature infants with an endogenous pulmonary surfactant deficiency. Poractant alfa is an extract of natural porcine lung surfactant consisting of 99% polar lipids (mainly phospholipids)...
Approved
Matched Description: … Poractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada. ... 1% hydrophobic low molecular weight proteins (surfactant associated proteins SP-B and SP-C). ... an extract of natural porcine lung surfactant consisting of 99% polar lipids (mainly phospholipids) and …
Istradefylline
Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A2A receptors in the basal ganglia. This region of the brain is highly involved in motor control. Istradefylline...
Approved
Investigational
Matched Description: … [A184067]
Istradefylline is indicated as an adjunct treatment to [levodopa] and [carbidopa] for Parkinson's …
Cat dander extract
Cat dander extract is either subcutaneously or intracutaneously administered and contains dry cat dander or dry defatted cat pelt. It is used in the diagnosis and treatment (immunotherapy) of patients with a history of allergy to cats. An allergic reaction to cats is induced by the presence of antigen-specific IgE...
Approved
Matched Description: … Cat dander extract is either subcutaneously or intracutaneously administered and contains dry cat dander ... It is used in the diagnosis and treatment (immunotherapy) of patients with a history of allergy to cats ... The allergy diagnostic process involves assessing allergy history, clinical evaluation, and skin test …
Glasdegib
Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionality. The great lipophilicity of this group of compounds...
Approved
Investigational
Matched Description: … [A40310]
Glasdegib was developed by Pfizer Inc and approved on November 21, 2018 by the FDA for the ... interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and ... monotherapy is limited, the landmark Phase 2 Bright AML 1003 trial showed a superior overall survival and …
Matched Salts name: … Glasdegib hydrochloride …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Salts name: … Glasdegib hydrochloride …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Myrrh
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, obtained from Commiphora abyssinica, Burseraceae.
Approved
Matched Description: … Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential …
Pipotiazine
Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is...
Approved
Investigational
Matched Description: … for causing hypotension or potentiating the effects of CNS depressants and anesthetics. ... Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity ... Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation …
Nitrous oxide
Nitrous oxide, commonly known as "laughing gas", is a chemical compound with the chemical formula N2O. At room temperature, it is a colorless non-flammable gas, with a pleasant, slightly sweet odor and taste. It is used in surgery and dentistry for its anesthetic and analgesic effects. It is known as...
Approved
Vet approved
Matched Description: … It is used in surgery and dentistry for its anesthetic and analgesic effects. ... At room temperature, it is a colorless non-flammable gas, with a pleasant, slightly sweet odor and taste …
Pergolide
Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome....
Approved
Investigational
Vet approved
Withdrawn
Matched Description: … It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine ... The drug was withdrawn from the US market in March 2007 and from the Canadian market in August 2007. …
Matched Categories: … Ergot Alkaloids and Derivatives …
Matched Categories: … Ergot Alkaloids and Derivatives …
Dimethicone 410
Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products. It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit. It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%....
Approved
Matched Description: … It is reported that the term dimethicone includes the notation of polydimethylsiloxane and trimethylsiloxy-terminated …
Deferiprone
Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired....
Approved
Alirocumab
Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and statin treatment. It is a human monoclonal antibody part of the family of the PCSK9 inhibitors which...
Approved
Matched Description: … high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and ... FDA approval was contingent on the completion of further clinical trials to better determine efficacy and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Strontium chloride Sr-89
Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stages of the disease. It...
Approved
Investigational
Matched Description: … lung, bladder and thyroid. ... It is usually presented mainly in patients with prostatic and breast cancer, as well as in cancer of ... [A31264] Bone metastases is a common and severe complication presented in advanced stages of the disease …
Benziodarone
Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients [T487, A175636].
Approved
Withdrawn
Matched Description: … Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz ... It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients …
Favipiravir
Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza.[A191688,A191721] The antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and replication of viral genomes.[A191688,A191772,A191775]
Not only does favipiravir inhibit...
Approved
Investigational
Matched Description: … [A191688,A191772,A191775]
Not only does favipiravir inhibit replication of influenza A and B, but ... the drug has shown promise in the treatment of avian influenza, and may be an alternative option for ... antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and …
Rasagiline
Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Approved
Matched Description: … Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's …
Temoporfin
Temoporfin is a photosensitizing agent used in the treatment of squamous cell carcinoma of the head and neck [FDA Label]. It was first authorized for market by the European Medicines Agency in October 2001. It is currently available under the brand name Foscan.
Approved
Investigational
Matched Description: … Temoporfin is a photosensitizing agent used in the treatment of squamous cell carcinoma of the head and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Tenapanor
Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant irritable bowel-syndrome (IBS-C). It was first designed and synthesized in 2012. As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and currently only medication within its class[A185489,A185492,A185495] and...
Approved
Investigational
Matched Description: … [L8558] It was first designed and synthesized in 2012. ... currently only medication within its class[A185489,A185492,A185495] and therefore exists as a novel ... A185492] As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and …
Matched Salts name: … Tenapanor hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Salts name: … Tenapanor hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism …
Tranylcypromine
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311).
Tranylcypromine is a racemate comprising...
Approved
Investigational
Matched Description: … monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and ... It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). ... Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1- …
Calfactant
Calfactant is a sterile, non-pyrogenic lung surfactant intended for intratracheal instillation. It is an off-white suspension of an extract of natural surfactant from calf lungs suspended in 0.9% saline. Each milliliter of calfactant contains 35mg of phospholipids (including 26 mg phosphatidylcholine of which 16 mg is disaturated phosphatidylcholine) and 0.65mg...
Approved
Matched Description: … 0.65mg of proteins including surfactant-associated proteins B and C. ... phospholipids (including 26 mg phosphatidylcholine of which 16 mg is disaturated phosphatidylcholine) and ... decrease the incidence of respiratory distress syndrome, mortality due to respiratory distress syndrome, and …
Displaying drugs 2476 - 2500 of 15068 in total