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Displaying drugs 326 - 350 of 1727 in total

Vinflunine

Vinflunine is a third-generation member of the vinca alkaloid family with anti-tumour actions. It was first described in 1998 at the Pierre Fabre research center in France. Like other vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and promotes cell death...
Approved
Investigational
Matched Iupac: … methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^{3,11}.0^{4,9}]octadeca-3(11),4,6,8-tetraen-12-yl]-12-ethyl …

Roxithromycin

Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to erythromycin, azithromycin, or clarithromycin. It was shown to be more effective against certain Gram-negative bacteria, particularly Legionella pneumophila. Roxithromycin exerts its antibacterial action by binding to the bacterial ribosome and interfering with bacterial protein synthesis. It is...
Approved
Investigational
Withdrawn
Matched Iupac: … 5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl …

Spinosad

Spinosad is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively) used in the topical treatment of head lice in children (four years old and older) and in adults. Spinosad is an insecticide based on a compound found in S. spinosa, a bacterial species....
Approved
Investigational
Vet approved
Matched Iupac: … (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-13-{[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy}-9-ethyl ... dione; (2S,3aR,5aS,5bS,9S,13S,14R,16aS,16bS)-13-{[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy}-9-ethyl …

Etidronic acid

Etidronic acid is a first generation bisphosphonate similar to clodronic acid and tiludronic acid. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid,...
Approved

Telavancin

Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others.
Approved
Matched Iupac: … 28R,40S)-22-(carbamoylmethyl)-5,47-dichloro-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-{[2-(decylamino)ethyl …

Gentamicin

Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment...
Approved
Vet approved
Matched Iupac: … oxane-3,5-diol; (2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-[1-(methylamino)ethyl …

Icosapent ethyl

Icosapent ethyl or ethyl eicosapentaenoic acid is a synthetic derivative of the omega-3 fatty acid eicosapentaenoic acid (EPA). It is used as an adjunct therapy for severe hypertriglyceridemia (TG levels > 500 mg/dL) and to reduce the risk of cardiovascular events in certain patients with elevated triglycerides. FDA approved on...
Approved
Investigational
Nutraceutical
Matched Synonyms: … Ethyl-EPA ... Icosapent ethyl ... Ethyl icosapentate …
Matched Name: … Icosapent ethyl …
Matched Iupac: … ethyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate …
Matched Description: … Icosapent ethyl or ethyl eicosapentaenoic acid is a synthetic derivative of the omega-3 fatty acid eicosapentaenoic …
Matched Products: … Icosapent Ethyl ... Icosapent ethyl …

Telotristat ethyl

Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942]...
Approved
Investigational
Matched Synonyms: … Telotristat ethyl …
Matched Name: … Telotristat ethyl …
Matched Iupac: … ethyl (2S)-2-amino-3-(4-{2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy …
Matched Description: … Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. ... [A252937, A252942] Currently, telotristat ethyl is used to treat carcinoid syndrome diarrhea from neuroendocrine …

Ethyl hydroxybenzoate

Approved
Experimental
Matched Synonyms: … Ethyl paraben ... Ethyl p-hydroxybenzoate ... 4-hydroxybenzoic acid ethyl ester …
Matched Name: … Ethyl hydroxybenzoate …
Matched Iupac: … ethyl 4-hydroxybenzoate …
Matched Categories: … ethyl hydroxybenzoate …

Omega-3-acid ethyl esters

Omega-3-acid ethyl esters are prescription drugs that contain eicosapentaenoic acid-ethyl ester (EPA) and docosahexaenoic acid-ethyl ester (DHA) that are used in combination with changes in diet to lower triglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia[FDA Label] . Omega-3-acid ethyl esters are currently marketed in the US, EU,...
Approved
Investigational
Matched Synonyms: … Omega-3-acid ethyl esters ... Omega-3 fatty acid ethyl esters …
Matched Name: … Omega-3-acid ethyl esters …
Matched Description: … Omega-3-acid ethyl esters are prescription drugs that contain eicosapentaenoic acid-ethyl ester (EPA) ... and docosahexaenoic acid-ethyl ester (DHA) that are used in combination with changes in diet to lower ... Omega-3-acid ethyl esters are currently marketed in the US, EU, and many other regions under the brand …
Matched Products: … Omega-3-acid Ethyl Esters ... Omega-3-Acid Ethyl Esters ... Omega-3-Acid Ethyl Ester …

Ethinylestradiol

Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering. It was developed in an effort to create an estrogen with greater oral bioavailability. These properties were achieved by the substitution of an ethinyl group at carbon 17 of estradiol. Ethinylestradiol soon replaced mestranol in...
Approved
Matched Synonyms: … Ethinyl estradiol ... Ethynyl estradiol ... 17-ethinyl-3,17-estradiol …
Matched Description: … [A191107] These properties were achieved by the substitution of an ethinyl group at carbon 17 of [estradiol …
Matched Mixtures name: … Norgestimate and Ethinyl Estradiol ... Norgestimate and Ethinyl Estradiol ... Norgestimate and Ethinyl Estradiol …
Matched Categories: … Estradiol Congeners ... norgestimate and ethinylestradiol ... norgestimate and ethinylestradiol …

Estramustine

A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Approved
Investigational
Matched Synonyms: … 17β-Estradiol 3-(bis(2-chloroethyl)carbamate) ... Estradiol 3-(N,N-bis(2-chloroethyl)carbamate) …
Matched Description: … A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also …
Matched Categories: … Estradiol Congeners …

Hydroxyethyl ethylcellulose

Hydroxyethyl ethylcellulose modulates bacterial binding to salivary pellicle; moderately effective in preventing plaque formation.
Approved
Experimental
Matched Synonyms: … Ethyl hydroxyethylcellulose ... Ethyl hydroxyethyl cellulose ... Ethyl-2-hydroxyethylcellulose …

Benzocaine

Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.
Approved
Investigational
Matched Synonyms: … Amben ethyl ester ... Ethyl aminobenzoate ... Ethyl p-aminobenzoate …
Matched Iupac: … ethyl 4-aminobenzoate …

Clofibrate

A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)
Approved
Investigational
Matched Synonyms: … Ethyl clofibrate ... Ethyl chlorophenoxyisobutyrate ... Ethyl 2-(p-chlorophenoxy)isobutyrate …
Matched Iupac: … ethyl 2-(4-chlorophenoxy)-2-methylpropanoate …

Artemotil

Artemotil, also known as β-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases.
Approved
Matched Synonyms: … Dihydroartemisinin ethyl ether ... beta-Dihydroartemisinin ethyl ether …

Ethosuximide

An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
Approved
Matched Synonyms: … 2-ethyl-2-methylsuccinimide ... (±)-2-ethyl-2-methylsuccinimide ... 3-ethyl-3-methylsuccinimide …
Matched Iupac: … 3-ethyl-3-methylpyrrolidine-2,5-dione …

Etomidate

Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Approved
Matched Synonyms: … 3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester ... (+)-ethyl 1-(α-methylbenzyl)imidazole-5-carboxylate ... R-(+)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate …
Matched Iupac: … ethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate …

Elacestrant

Elacestrant is a non-steroidal small molecule and an estrogen receptor (ER) antagonist.[A256838,L44918] In January 2023, it was approved by the FDA for the treatment of ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer.[L44918,L44948] It received a similar approval in the EU in September 2023. Elacestrant binds to estrogen receptor-alpha (ERα)...
Approved
Investigational
Matched Synonyms: … (2R)-2-(2-(ethyl-((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxy-phenyl)tetralin-6-ol ... (6R)-6-(2-(ethyl((4-(2- (ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)- 5,6,7,8-tetrahydronaphthalen ... 2-naphthalenol, 6-(2-(ethyl((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydro …
Matched Iupac: … (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen …

Rivastigmine

Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Approved
Investigational
Matched Synonyms: … (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate ... m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate …
Matched Iupac: … 3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate …

Bretylium

Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. Recent evidence...
Approved
Matched Synonyms: … 2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium ... N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminium …
Matched Iupac: … [(2-bromophenyl)methyl](ethyl)dimethylazanium …

Obeticholic acid

Primary biliary cirrhosis, or PBC, is a progressive and chronic condition that leads to hepatic injury often resulting in end-stage liver failure that requires liver transplantation. Obeticholic acid is a farnesoid-X receptor (FXR) agonist used to treat this condition, possibly allowing for increased survival. In 2016, it was granted approval...
Approved
Matched Synonyms: … 6-Ethyl-CDCA ... 6alpha-Ethyl-chenodeoxycholic acid ... (3α,5β,6α,7α)-6-ethyl-3,7-dihydroxycholan-24-oic acid …
Matched Iupac: … (4R)-4-[(1R,3aS,3bS,4R,5R,5aS,7R,9aS,9bS,11aR)-5-ethyl-4,7-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta …

Phenobarbital

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Approved
Investigational
Matched Synonyms: … 5-Ethyl-5-phenylbarbituric acid ... 5-Ethyl-5-phenyl-pyrimidine-2,4,6-trione ... 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione …
Matched Iupac: … 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione …

Thioridazine

A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed,...
Approved
Withdrawn
Matched Synonyms: … 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine ... 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine ... 3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazine …
Matched Iupac: … 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine …

Alfentanil

A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Approved
Illicit
Matched Synonyms: … N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide …
Matched Iupac: … N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide …
Displaying drugs 326 - 350 of 1727 in total