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Displaying drugs 426 - 450 of 14640 in total

Deflazacort

Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dystrophin gene, which...
Approved
Investigational
Matched Description: … This disease can cause serious muscle weakness and progressive breathing and cardiovascular disability ... , severely impacting patient quality of life and survival. ... It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA. …
Matched Categories: … Sex Hormones and Insulins …

Mitapivat

Mitapivat is a novel, first-in-class pyruvate kinase activator. It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival of red blood cells. Defects in the pyruvate kinase enzyme in various red blood cells disorders lead to the lack of energy production for red...
Approved
Investigational
Matched Description: … alpha- and beta-thalassemia. ... other hereditary red blood cell disorders associated with hemolytic anemia, such as sickle cell disease and …
Matched Categories: … Blood and Blood Forming Organs ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Rosuvastatin

Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications...
Approved
Matched Description: … studies to significantly reduce the risk of development of CVD and all-cause mortality. ... belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and ... of metabolic reactions involved in the production of several compounds involved in lipid metabolism and …
Matched Mixtures name: … Rosuvastatin and Ezetimibe ... Rosuvastatin and Ezetimibe ... Rosuvastatin and Ezetimibe …
Matched Categories: … Alimentary Tract and Metabolism ... rosuvastatin and ramipril ... rosuvastatin and valsartan ... rosuvastatin and ezetimibe ... rosuvastatin and amlodipine …

Ferric maltol

Ferric maltol is an iron(III) atom complexed with 3 maltol molecules to increase the bioavailability compared to iron(II), without depositing it in the duodenum as insoluble ferric hydroxide and phosphate. Ferric maltol has been described in literature since at least the late 1980s as a potential treatment for iron deficiency....
Approved
Matched Description: … bioavailability compared to iron(II), without depositing it in the duodenum as insoluble ferric hydroxide and …
Matched Categories: … Blood and Blood Forming Organs …

Ulobetasol

Ulobetasol is a highly potent corticosteroid. It is structurally related to clobetasol. Due to its high potency, it is mainly prescribed in the treatment of severe plaque psoriasis and corticosteroid responsive dermatoses.[L15047,L15052,L15102] Ulobetasol was granted FDA approval on 17 December 1990.
Approved
Matched Description: … A215597] Due to its high potency, it is mainly prescribed in the treatment of severe plaque psoriasis and …
Matched Categories: … tazarotene and ulobetasol …

Protriptyline

Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive...
Approved
Matched Description: … In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic ... TCAs are potent inhibitors of serotonin and norepinephrine reuptake. ... receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred …

Bepotastine

Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. Bepotastine was approved in Japan for use in the treatment of allergic rhinitis and uriticaria/puritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the brand name Talion. It is available...
Approved
Matched Description: … in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the brand ... It is available in oral and opthalmic dosage forms in Japan. ... The opthalmic solution is FDA approved since Sept 8, 2009 and is under the brand name Bepreve. …

Sorghum halepense pollen

Sorghum halepense pollen is the pollen of the Sorghum halepense plant. Sorghum halepense pollen is mainly used in allergenic testing.
Approved
Matched Mixtures name: … Mixture of Standardized and Non-Standardized Southern Grasses ... Mixture of Twenty-Two Standardized and Non-Standardized Grasses …

Finasteride

Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fashion as dutasteride, which is another 5-alpha-reductase inhibitor, by exerting antiandrogenic effects. Finasteride is an orally active drug...
Approved
Matched Description: … Finasteride is a synthetic 4-azasteroid compound [L10565] and specific inhibitor of steroid Type II 5α-reductase ... [L6244] Finasteride is commonly marketed under the brand names Propecia and Proscar to be used aloneo ... first approved by the FDA in 1992 for the treatment of benign prostatic hyperplasia to improve symptoms and …
Matched Categories: … doxazosin and finasteride ... alfuzosin and finasteride ... finasteride and tadalafil ... Skin and Mucous Membrane Agents ... Genito Urinary System and Sex Hormones …

Frangula purshiana bark

Approved
Experimental
Matched Mixtures name: … Mucinum (cascara and Senna Tablets) …

Plazomicin

Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from DB12604. The structure of plazomicin was established via appending hydroxylaminobutyric acid to DB12604 at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglycoside-modifying enzymes, which contribute to the main...
Approved
Investigational
Matched Description: … extended-spectrum beta-lactamase (ESBL) producing _Enterobacteriaceae_. ... It is marketed as Zemdri and is administered via once-daily intravenous infusion. ... However, acquired resistance of aminoglycosides may arise through over expression of efflux pumps and …

Rifaximin

Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction in risk of...
Approved
Investigational
Matched Description: … It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction ... encephalopathy recurrence; as well as diarrhea-predominant irritable bowel syndrome (IBS-D) in adult women and …
Matched Categories: … Alimentary Tract and Metabolism …

Dexchlorpheniramine maleate

Dexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
Approved
Matched Description: … Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic …
Matched Mixtures name: … Chlophedianol Hydrochloride, Dexchlorpheniramine Maleate, and Pseudoephedrine Hydrochloride …

Interferon alfa-n3

Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD).
Approved
Investigational
Matched Description: … for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …

Exagamglogene autotemcel

Sickle cell disease (SCD) is a genetic disorder characterized by the production of abnormal sickle-shaped red blood cells (called hemoglobin S, HbS) that initiate a pathophysiology resulting in severe pain, progressive multi-organ damage, and premature death. Treatment options for SCD are largely focused on preventing the production and circulation of...
Approved
Investigational
Matched Description: … cells which has been investigated in clinical trials for the treatment of severe SCD and severe beta-thalassemia ... [A262691] Treatment options for SCD are largely focused on preventing the production and circulation ... ] - a mainstay of treatment since the 1990s - as well as newer agents like [crizanlizumab] and [voxelotor …
Matched Categories: … Blood and Blood Forming Organs …

Tigecycline

Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S. Food and Drug Administration (FDA) on June 17, 2005.
Approved
Matched Description: … Food and Drug Administration (FDA) on June 17, 2005. ... Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil …

Desipramine

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive...
Approved
Investigational
Matched Description: … TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic ... as amitriptyline and clomipramine. ... TCAs are potent inhibitors of serotonin and norepinephrine reuptake. …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …

Lovastatin

Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terreus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid...
Approved
Investigational
Matched Description: … Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite ... studies to significantly reduce the risk of development of CVD and all-cause mortality. ... belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and …
Matched Categories: … lovastatin and nicotinic acid …

Acetylcysteine

Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose.[L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.[A228158,A228163,A228168] Acetylcysteine was granted FDA approval on 14 September 1963.
Approved
Investigational
Matched Description: … Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment …
Matched Mixtures name: … Levomefolate Calcium Acetylcysteine and Mecobalamin Algal ... Levomefolate Calcium, Acetylcysteine, Mecobalamin and Algal …
Matched Categories: … Cough and Cold Preparations ... Amino Acids, Peptides, and Proteins …

Estradiol acetate

Estradiol acetate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Description: … Because of the difference in potency between estradiol and estrone, menopause (and a change in primary ... a chance to enter systemic circulation and exert its estrogenic effects [A12102]. ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex …

Estradiol cypionate

Estradiol Cypionate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Description: … Because of the difference in potency between estradiol and estrone, menopause (and a change in primary ... skin, prostate, bone, fat, and brain. ... a chance to enter systemic circulation and exert its estrogenic effects [A12102]. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Methionine

A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.
Approved
Nutraceutical
Matched Mixtures name: … Aminosyn II and Dextrose ... Aminosyn II and Dextrose ... Men's Biomultiple Vitamin and Mineral Supplement …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Phentermine

Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows this agent to...
Approved
Illicit
Matched Description: … Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity ... [A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical ... [A174367] Phentermine was FDA approved for short-term weight management in 1959 and it became widely …
Matched Categories: … Alimentary Tract and Metabolism ... phentermine and topiramate …

Ethionamide

A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Approved
Matched Description: … (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) …

Benzphetamine

A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
Approved
Illicit
Displaying drugs 426 - 450 of 14640 in total