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Gilteritinib

Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression observed in other...
Approved
Investigational
Matched Description: … -driven myelosuppression observed in other therapies. ... Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors ... that presented a greater selectivity and potency when compared with other agents from this group. …

Piperaquine

Piperaquine is an antimalarial agent first synthesized in the 1960's and used throughout China . Its use declined in the 1980's as piperaquine resistant strains of Plasmodium falciparum appeared and artemisinin derivatives became available. It has come back into use in combination with the artemisinin derivative DB11638 as part of...
Approved
Experimental
Investigational
Matched Description: … Eurartesim was first authorized for market by the European Medicines Agency in October 2011. ... Piperaquine is an antimalarial agent first synthesized in the 1960's and used throughout China [A31550 ... Its use declined in the 1980's as piperaquine resistant strains of *Plasmodium falciparum* appeared and …

Plicamycin

Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000.
Approved
Investigational
Withdrawn
Matched Description: … The manufacturer discontinued plicamycin in 2000. ... It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Nabumetone

Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a degree...
Approved
Matched Description: … acting as a potent COX inhibitor similar in structure to [naproxen]. ... still produces significant adverse effects in the GI tract. ... Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID). …

Nonoxynol-9

Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic effects. N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams,...
Approved
Withdrawn
Matched Description: … N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and ... Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. ... In several European countries, spermicides are no longer on the market. …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Hormonal Contraceptives for Systemic Use …

Tolcapone

Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity.
Approved
Withdrawn
Matched Description: … It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. ... Tolcapone is associated with a risk of hepatotoxicity. ... It is a yellow, odorless, non-hygroscopic, crystalline compound. …

Dichlorobenzyl alcohol

Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other...
Approved
Matched Description: … Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated ... for approved drug products. ... [L1113] On the other hand, dichlorobenzyl alcohol is categorized by the FDA in the inactive ingredient …

Torasemide

Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993.
Approved
Matched Description: … [A319] Torasemide was first approved for clinical use by the FDA in 1993.[L5257] ... Torasemide is a high-ceiling loop diuretic. ... [A174463] Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Relugolix

Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under the brand name...
Approved
Investigational
Matched Description: … of testosterone levels when compared to [leuprolide], another androgen deprivation therapy used in the ... Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several ... It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment …

Perflutren

Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the...
Approved
Matched Description: … Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated ... level of contrast visible in the resulting ultrasound image. ... The difference in density between the gas-filled bubbles and the blood around them creates an increased …
Matched Mixtures name: … Optison Perflutren Protein-Type A Microspheres …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Bezlotoxumab

Bezlotoxumab is a fully humanized ImmunoglobulinG1 (IgG1) kappa monoclonal antibody that binds to Clostridium difficile toxin B and neutralizes its effects. First approved by the FDA on October 21, 2016, bezlotoxumab is used to reduce the recurrence of C. difficile infection. On November 22, 2016, the Committee for Medicinal Products...
Approved
Investigational
Matched Description: … [L46976] On November 22, 2016, the Committee for Medicinal Products for Human Use of the European Medicines ... Agency recommended the granting of a marketing authorization. ... Bezlotoxumab is a fully humanized ImmunoglobulinG1 (IgG1) kappa monoclonal antibody that binds to _Clostridium …
Matched Categories: … Antiinfectives for Systemic Use …

Desipramine

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive...
Approved
Investigational
Matched Description: … See toxicity section below for a complete listing of side effects. ... In depressed individuals, desipramine exerts a positive effect on mood. ... receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for …
Matched Categories: … Antidepressive Agents Indicated for Depression ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index …

Baloxavir marboxil

Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of baloxavir with an improved absorption profile than its active metabolite due to the addition of a phenolic hydroxyl...
Approved
Investigational
Matched Description: … More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza ... [A251760] Baloxavir marboxil was first globally approved in Japan in February 2018,[A39895] followed ... by the US approval in October, 2018. …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use …

Pindolol

Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the early 1970s....
Approved
Investigational
Matched Description: … Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. ... [A231059] Research into pindolol's use in the treatment of hypertension began in the early 1970s. …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Levomilnacipran

Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate milnacipran.[A261181, L47956] Once administered, interconversion between levomilnacipran and its stereoisomer does not occur in humans. First approved...
Approved
Investigational
Matched Description: … [L47956] While levomilnacipran was previously investigated and proposed as a potential treatment for ... a more potent inhibitor of norepinephrine reuptake than serotonin reuptake. ... stroke in Europe, the EMA decided against this use. …
Matched Categories: … Antidepressive Agents Indicated for Depression …

Pentobarbital

A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA...
Approved
Investigational
Vet approved
Matched Description: … A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) ... It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may …

Gluconic Acid

Commonly found in salts with sodium and calcium. Gluconic acid or gluconate is used to maintain the cation-anion balance on electrolyte solutions.
Approved
Investigational
Matched Description: … Commonly found in salts with sodium and calcium. …
Matched Mixtures name: … Plasma-Lyte A ... Isolyte S in Dextrose ... PLASMA-LYTE A INJECTION …

Methenamine

Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).
Approved
Vet approved
Matched Description: … In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate ... Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. …
Matched Mixtures name: … All-In-One UTI Emergency Kit …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Daridorexant

Daridorexant, formerly known as nemorexant, is a selective dual orexin receptor antagonist used to treat insomnia. Insomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of daytime functioning. It chronically affects the person's daily functioning and long-term health effects, as insomnia is often associated with comorbidities...
Approved
Matched Description: … Conventional treatments for insomnia include drugs targeting gamma-aminobutyric acid type-A (GABA-A), ... sleep and daytime functioning in patients with insomnia. ... Daridorexant, formerly known as nemorexant, is a selective dual orexin receptor antagonist used to treat …

Colchicine

Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events....
Approved
Matched Description: … Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum ... [A183611] Its use was first approved by the FDA in 1961. ... [L47591] It has also been investigated in other inflammatory and fibrotic conditions.[A183602] …
Matched Categories: … Experimental Unapproved Treatments for COVID-19 …

Dapsone

A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of...
Approved
Investigational
Matched Description: … A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium ... It is also used with pyrimethamine in the treatment of malaria. ... action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in …
Matched Categories: … Antiinfectives for Systemic Use ... Drugs for Treatment of Lepra ... Anti-Acne Preparations for Topical Use ... Antibiotics for Pneumocystis Pneumonia …

Aceclofenac

Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies [A19667, A19668, A19670]. Aceclofenac potently inhibits the...
Approved
Investigational
Matched Description: … It is a more commonly prescribed drug in Europe. ... In 1991, aceclofenac was developed as an analog of a commonly prescribed NSAID, [DB00586], via chemical ... It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional …
Matched Categories: … Topical Products for Joint and Muscular Pain ... Antiinflammatory Preparations, Non-Steroids for Topical Use …

Peanut oil

Peanut oil is derived from Arachis hypogaea which can be found in South America, Mexico, and Centro America. The kernels are consumed roasted but a large percentage is used for the production of vegetable oil. The peanut oil represents about 45-52% of the kernel content and it is mainly formed...
Approved
Matched Description: … The kernels are consumed roasted but a large percentage is used for the production of vegetable oil. ... [A33169] Under the FDA, peanut oil is categorized as an approved inactive ingredient for its use in ... Peanut oil is derived from _Arachis hypogaea_ which can be found in South America, Mexico, and Centro …

Dyphylline

Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.
Approved
Matched Description: … Dyphylline is a theophylline derivative with broncho- and vasodilator properties. ... It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. …
Matched Mixtures name: … ESPEKTAN A ŞURUP, 100 ML …
Matched Categories: … Drugs for Obstructive Airway Diseases …

Flavin adenine dinucleotide

A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) Flavin adenine dinucleotide is approved for use in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency.
Approved
Matched Description: … in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency. ... A condensation product of riboflavin and adenosine diphosphate. ... (Lehninger, Principles of Biochemistry, 1982, p972) Flavin adenine dinucleotide is approved for use …
Displaying drugs 601 - 625 of 14030 in total