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Displaying drugs 651 - 675 of 12589 in total

Ixabepilone

Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. Ixabepilone is...
Approved
Investigational
Matched Description: … Ixabepilone is a semisynthetic analogue of epothilone B. ... It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally …

Fursultiamine

Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative.
Approved
Matched Description: … Compound used for therapy of thiamine deficiency. …

Metolazone

A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss.
Approved
Matched Categories: … combinations of sulfonamides …

Mestranol

The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
Approved
Matched Iupac: … )-1-ethynyl-7-methoxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-ol …
Matched Description: … It is used as the estrogen component of many combination ORAL contraceptives. ... The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. …

Nebivolol

Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than atenolol, propranolol, or pindolol. Nebivolol and other beta...
Approved
Investigational
Matched Iupac: … 2H-1-benzopyran-2-yl)-2-{[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino}ethan-1-ol …
Matched Description: … Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other …

Gadolinium

Gadolinium is under investigation in Hypertension, ACUTE KIDNEY INJURY, and Chronic Kidney Disease. Gadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery Disease.
Approved
Investigational
Matched Description: … Gadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery …
Matched Categories: … Diagnostic Uses of Chemicals …

Eplerenone

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of...
Approved
Matched Description: … the negative regulatory feedback of aldosterone on renin secretion. ... shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of ... resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of …

Lanthanum carbonate

Lanthanum carbonate is a phosphate binder marketed under the trade name Fosrenol by Shire Pharmaceuticals. It is a large pill that requires thorough chewing to avoid choking and other gastrointestinal adverse effects. It is used to treat elevated phosphate levels, primarily in patients with chronic kidney disease, by binding to...
Approved
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …

Troglitazone

Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Approved
Investigational
Withdrawn
Matched Description: … Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. …

Encainide

All drug products containing encainide hydrochloride. Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. The manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991.
Approved
Investigational
Withdrawn
Matched Description: … The manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16 …

Omadacycline

Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections, Community-Acquired Infections, and Skin Structures and Soft Tissue Infections. Omadacycline represents a significant advance over the well-known tetracycline family, and has been shown to be highly effective in animal models at treating increasingly problematic, clinically prevalent...
Approved
Investigational
Matched Description: … Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections ... gram-negative, atypical and anaerobic bacteria, including those resistant to currently available classes of …
Matched Categories: … combinations of tetracyclines …

Lorazepam

Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.
Approved

Labetalol

Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984.
Approved
Matched Description: … 25% of the mixture. ... Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up …

Lomitapide

Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Approved
Investigational

Lemborexant

Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance. Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits,...
Approved
Investigational
Matched Description: … a new wave of treatment options for patients suffering from insomnia. ... Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized ... [L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driven …

Iohexol

Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
Approved
Matched Description: … Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. …
Matched Categories: … Diagnostic Uses of Chemicals …

Haloperidol

Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor (mainly D2), particularly within...
Approved
Matched Description: … Haloperidol is indicated for the treatment of the manifestations of several psychotic disorders including ... for the management of the "positive" symptoms of schizophrenia including hallucinations, hearing voices ... However, this class of drugs is also limited by the development of movement disorders induced by dopamine-blockade …

Buspirone

Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, buspirone does...
Approved
Investigational
Matched Description: … been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of ... It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin ... [L7375] The potential use of buspirone in combination with [melatonin] in depression and cognitive impairment …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Diamorphine

Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is controlled under...
Approved
Illicit
Investigational
Matched Description: … Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). ... (Merck Index, 11th ed) Internationally, diamorphine is controlled under Schedules I and IV of the Single …

Pholcodine

Pholcodine formula is 3-o-morpholinoethylmorphine and it is classified as an antitussive which is defined as an opioid cough suppressant. It belongs to the opioid family of compounds and it is widely used. Pholcodine activity is the suppression of unproductive cough and it also has a mild sedative effect with little...
Approved
Illicit
Matched Iupac: … yl)ethoxy]-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,15-tetraen-14-ol …
Matched Description: … It belongs to the opioid family of compounds and it is widely used. ... It is categorized as Class B drug in the UK and officially taken out of the shelves in 2008. ... [A31738] Pholcodine activity is the suppression of unproductive cough and it also has a mild sedative …

Trypsin

Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine....
Approved
Vet approved
Matched Description: … Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is ... an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of ... This nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate- …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …

Gadobutrol

Gadobutrol is a second-generation extracellular non-ionic macrocyclic GBCA (gadolinium-based contrast agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of age. Due to its physicochemical properties, gadobutrol is formulated at twice the gadolinium ion concentration compared to other GBCA and thus requires a lesser...
Approved
Matched Description: … of NSF thanks to the macrocyclic structures that limit dechelation of gadolinium. ... contrast agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of ... [A7001] Like other GBCA, gadobutrol usage carries the risk of nephrogenic systemic fibrosis (NSF) …
Matched Categories: … Diagnostic Uses of Chemicals …

Perflubutane

Perflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable ultrasound to compete more effectively with nuclear stress testing; currently the leading procedure for detecting coronary heart disease.
Approved
Investigational
Matched Description: … Perflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis …
Matched Categories: … Diagnostic Uses of Chemicals …

Flurazepam

A benzodiazepine derivative used mainly as a hypnotic.
Approved
Illicit
Investigational

Dutasteride

Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary hormonal...
Approved
Investigational
Matched Description: … It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes ... Its clinical efficacy against benign prostate hyperplasia in male patients is comparable to that of [ ... However, unlike finasteride, dutasteride is not yet indicated for the treatment of androgenic alopecia …
Displaying drugs 651 - 675 of 12589 in total