Displaying drugs 676 - 700 of 10485 in total
Burosumab
Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic rickets .
The U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. This is the first drug approved...
Approved
Investigational
Mitapivat
Mitapivat is a novel, first-in-class pyruvate kinase activator. It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival of red blood cells. Defects in the pyruvate kinase enzyme in various red blood cells disorders lead to the lack of energy production for red...
Approved
Investigational
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Nabumetone
Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a degree...
Approved
Matched Synonyms: … 4-(6-Methoxy-2-naphthyl)-2-butanone ... 4-(6-Methoxy-2-naphthalenyl)-2-butanone …
Matched Iupac: … 4-(6-methoxynaphthalen-2-yl)butan-2-one …
Matched Description: … [A179077] While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone ... [label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite …
Matched Categories: … COX-2 Inhibitors ... Selective Cyclooxygenase 2 Inhibitors (NSAIDs) …
Matched Iupac: … 4-(6-methoxynaphthalen-2-yl)butan-2-one …
Matched Description: … [A179077] While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone ... [label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite …
Matched Categories: … COX-2 Inhibitors ... Selective Cyclooxygenase 2 Inhibitors (NSAIDs) …
Autologous peripheral blood-derived CD34+ cells
Autologous peripheral blood-derived CD34+ cells, or CLBS119 (a proprietary version being developed by Caladrius Biosciences, Inc.), are hematopoietic stem cells. It is also a cell therapy being investigated by Caladrius Biosciences in the clinical trial NCT04522817 (CLBS119 for Repair of COVID-19 Induced Pulmonary Damage).
Approved
Investigational
Estradiol cypionate
Estradiol Cypionate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Iupac: … 9bS,11aS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl 3- …
Matched Description: … primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 ... produced with an ester side-chain as endogenous estradiol has very low oral bioavailability on its own (2- …
Matched Description: … primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 ... produced with an ester side-chain as endogenous estradiol has very low oral bioavailability on its own (2- …
Deferoxamine
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Approved
Investigational
Matched Iupac: … N-(5-aminopentyl)-N-hydroxy-N'-[5-(N-hydroxy-3-{[5-(N-hydroxyacetamido)pentyl]carbamoyl}propanamido)pentyl …
Dioxybenzone
Dioxybenzone, or benzophenone-8, is an organic compound derived from DB01878 that is used as a sunscreen agent. It absorbed UV-B and UV-AII rays. Dioxybenzone is an approved sunscreen ingredient in concentrations up to 3% .
Approved
Matched Iupac: … 2-(2-hydroxybenzoyl)-5-methoxyphenol …
Matched Description: … Dioxybenzone is an approved sunscreen ingredient in concentrations up to 3% [L2525]. …
Matched Description: … Dioxybenzone is an approved sunscreen ingredient in concentrations up to 3% [L2525]. …
Sulfathiazole
Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide.
Except for those formulated for vaginal use, the FDA withdrew its approval for the use of...
Approved
Vet approved
Withdrawn
Matched Synonyms: … 2-Sulfonamidothiazole ... 2-Sulfanilamidothiazol ... 2-Sulfanilamidothiazole …
Matched Iupac: … 4-amino-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide …
Matched Iupac: … 4-amino-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide …
Propiolactone
Propiolactone is a lactone compound with a four-membered ring. It is a colorless liquid with a pungent slightly sweet odor. Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes. It has been used against bacteria, fungi, and virus. It is currently...
Approved
Withdrawn
Matched Synonyms: … 3-propanolide …
Matched Iupac: … oxetan-2-one …
Matched Iupac: … oxetan-2-one …
Technetium Tc-99m tetrofosmin
Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin. It is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit...
Approved
Matched Iupac: … bis(6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane) (⁹⁸Tc)technetium dihydrate …
Matched Description: … The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands …
Matched Description: … The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands …
Glimepiride
First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive...
Approved
Matched Iupac: … 3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)- …
Matched Description: … Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by ... Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes ... glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 …
Matched Mixtures name: … GLUCOVEL 2 ... LAPIGIM 2/500 ... VELACOM PLUS 2/500 …
Matched Products: … GLUVAS 3 ... GLAMAROL 3 ... AMAGLU 3 …
Matched Description: … Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by ... Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes ... glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 …
Matched Mixtures name: … GLUCOVEL 2 ... LAPIGIM 2/500 ... VELACOM PLUS 2/500 …
Matched Products: … GLUVAS 3 ... GLAMAROL 3 ... AMAGLU 3 …
Polyquaternium-10 (400 cps at 2%)
Polyquaternium-10 is a quaternized hydroxyethyl cellulose and a polycationic polymer. It is commonly found in cosmetics and personal care products to mainly reduce static electricity and form films.
Approved
Matched Name: … Polyquaternium-10 (400 cps at 2%) …
Migalastat
Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). This enzyme is responsible for breaking down glycosphingolipid substrate that, when deficient in patients with Fabry disease, builds up in the blood vessels, the kidneys,...
Approved
Investigational
Matched Iupac: … (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol …
Matched Salts cas: … 75172-81-5 …
Matched Salts cas: … 75172-81-5 …
Fexinidazole
Human African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by T. brucei gambiense and T. brucei rhodesiense, remains a moderate risk (>1/10,000 inhabitants per year in endemic areas) despite focussed control efforts. Transmitted by the bite of an infected tsetse fly, HAT is biphasic with a first...
Approved
Investigational
Matched Iupac: … 1-methyl-2-{[4-(methylsulfanyl)phenoxy]methyl}-5-nitro-1H-imidazole …
Matched Categories: … MATE 2 Inhibitors ... MATE 2-K Inhibitors …
Matched Categories: … MATE 2 Inhibitors ... MATE 2-K Inhibitors …
Sulesomab
Market product is Tc99m-labeled murine antibody fragment for nuclear imaging of activated granulocytes.
Approved
Glutamic acid
A peptide that is a homopolymer of glutamic acid.
Approved
Nutraceutical
Matched Synonyms: … (2S)-2-Aminopentanedioic acid ... (S)-2-Aminopentanedioic acid …
Matched Iupac: … (2S)-2-aminopentanedioic acid …
Matched Mixtures name: … Aminosyn II 5% Inj ... AMINOPLASMAL-5% E INFUSION …
Matched Iupac: … (2S)-2-aminopentanedioic acid …
Matched Mixtures name: … Aminosyn II 5% Inj ... AMINOPLASMAL-5% E INFUSION …
Opium
Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was...
Approved
Illicit
Matched Description: … It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years …
Armodafinil
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists...
Approved
Investigational
Matched Synonyms: … (–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide …
Matched Iupac: … 2-[(R)-diphenylmethanesulfinyl]acetamide …
Matched Iupac: … 2-[(R)-diphenylmethanesulfinyl]acetamide …
Ethyl ferulate
Approved
Experimental
Matched Synonyms: … Ethyl 4'-hydroxy-3'-methoxycinnamate …
Matched Iupac: … ethyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate …
Matched Iupac: … ethyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate …
Quinidine barbiturate
The administration of quinidine derivatives helps to observe various skin and mucosal reactions. A papulopurpuric eruption in a patient (without thrombopenia) can be developed who is taking quinidine phenylethyl barbiturate intermittently and at reintroduction.(PMID: 9739909)
Approved
Matched Iupac: … 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione; {5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(6-methoxyquinolin …
Chlorothiazide
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
Approved
Vet approved
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Ferric derisomaltose
Iron deficiency is an extremely common condition and is the most frequent cause of anemia worldwide. Iron deficiency results when iron intake, iron stores, and loss of iron from the body do not adequately support production of erythrocytes, also known as red blood cells. Though it is generally considered non...
Approved
Matched Iupac: … -(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl]oxy}hexane-1,2,3,4,5-pentol ... iron(3+) (2S,3R,4R,5R)-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6 …
Hyaluronic acid
Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and neural tissues; it was first isolated in 1934. Karl Meyer and John Palmer obtained glycosaminoglycan (GAG) from the bovine eye, giving it the name “hyaluronic acid”. HA is involved in many important physiological processes, including but not...
Approved
Vet approved
Matched Iupac: … -5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-{[(2R,3R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl ... (2S,3S,4R,5R,6R)-3-{[(2S,3R,5S,6R)-4-{[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy}-3-acetamido ... )oxan-4-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid …
Matched Mixtures name: … Calcipotriene 0.005% / Diclofenac Sodium 3% / Hyaluronic Acid Sodium Salt 2% / Niacinamide 2% ... Ascorbyl Palmitate 2% / Hyaluronic Acid Sodium Salt 0.2% / Niacinamide 5% / Tretinoin 0.025% ... Hyaluronic Acid 60mg and Lidocaine 2% PF …
Matched Products: … KYNEX 2 ... OSTENIL 20 MG 3 ENJEKTOR ... HYALGAN INJECTION 20 mg/2 ml …
Matched Mixtures name: … Calcipotriene 0.005% / Diclofenac Sodium 3% / Hyaluronic Acid Sodium Salt 2% / Niacinamide 2% ... Ascorbyl Palmitate 2% / Hyaluronic Acid Sodium Salt 0.2% / Niacinamide 5% / Tretinoin 0.025% ... Hyaluronic Acid 60mg and Lidocaine 2% PF …
Matched Products: … KYNEX 2 ... OSTENIL 20 MG 3 ENJEKTOR ... HYALGAN INJECTION 20 mg/2 ml …
Tubocurarine
Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera Chondrodendron and Strychnos....
Approved
Matched Synonyms: … 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium …
Matched Iupac: … {27,31}.0^{16,34}]hexatriaconta-3,5,8(34),9,11,18(33),19,21,24,26,31,35-dodecaen-15-ium ... 10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^{3,6}.1^{8,12}.1^{18,22}.0^ …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … {27,31}.0^{16,34}]hexatriaconta-3,5,8(34),9,11,18(33),19,21,24,26,31,35-dodecaen-15-ium ... 10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^{3,6}.1^{8,12}.1^{18,22}.0^ …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Bisphenol A diglycidyl ether
Approved
Experimental
Matched Iupac: … 2-{[4-(2-{4-[(oxiran-2-yl)methoxy]phenyl}propan-2-yl)phenoxy]methyl}oxirane …
Displaying drugs 676 - 700 of 10485 in total