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Displaying drugs 976 - 1000 of 14619 in total

Ritodrine

Adrenergic beta-agonist used to control premature labor.
Approved
Investigational
Matched Categories: … Genito Urinary System and Sex Hormones …

Anileridine

Anileridine is a synthetic opioid and strong analgesic medication. It is a narcotic pain reliever used to treat moderate to severe pain. Narcotic analgesics act in the central nervous system (CNS) to relieve pain. Some of their side effects are also caused by actions in the CNS.
Approved
Illicit
Matched Description: … Anileridine is a synthetic opioid and strong analgesic medication. …

Janssen COVID-19 Vaccine

The Janssen COVID-19 vaccine (Ad26.COV2.S) is a recombinant vaccine that contains an adenovirus serotype 26 (Ad26) vector expressing a stabilized SARS-CoV-2 spike protein. The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and the Beth Israel Deaconess Medical Center. A preclinical study in hamsters infected with...
Approved
Investigational
Matched Description: … The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and ... -2 infection[A220053] showed a single immunization with the vaccine-elicited neutralizing responses and ... protected against SARS-CoV-2 induced pneumonia and mortality, providing protection against the disease …

Gallamine triethiodide

A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may...
Approved
Matched Description: … may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. ... gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and …

Formaldehyde

A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor...
Approved
Vet approved
Matched Description: … , and as a laboratory fixative or preservative. ... Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. ... In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant …

Trichloroacetate

Trichloroacetate, or trichloroacetic acid, is a strong acid prepared by the reaction of chlorine with acetic acid in the presence of a suitable catalyst. In clinical chemistry and biochemistry, it is used as a precipitant of macromolecules including proteins, DNA and RNA. Trichloroacetate is also found in cosmetic treatments and...
Approved
Matched Description: … , DNA and RNA. ... Trichloroacetate is also found in cosmetic treatments and topical formulations as a cauterant, which ... In clinical chemistry and biochemistry, it is used as a precipitant of macromolecules including proteins …

Beeswax

The wax obtained from the honeycomb of the bee. It consists primarily of myricyl palmitate, cerotic acid esters and some high-carbon paraffins. Beeswax is used as a stiffening agent in ointments and creams, and enables water to be incorporated to produce water-in-oil emulsions. It is also used as a coating...
Approved
Matched Description: … Beeswax is used as a stiffening agent in ointments and creams, and enables water to be incorporated to ... It consists primarily of myricyl palmitate, cerotic acid esters and some high-carbon paraffins. …

Verteporfin

Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: CL-315555 and CL-315585. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red...
Approved
Investigational
Matched Description: … as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: [CL-315555] and ... Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light ... wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and …

Desvenlafaxine

Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of venlafaxine. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of adults with major depressive disorder (MDD).[L6016,A261271] MDD is a highly...
Approved
Investigational
Matched Description: … a highly prevalent psychiatric disorder, with a lifetime prevalence estimate of 16% in the US alone and ... [A261271] Desvenlafaxine has a very similar pharmacological, efficacy, and safety profile as [venlafaxine …
Matched Categories: … Serotonin and Noradrenaline Reuptake Inhibitors …

Foreskin keratinocyte (neonatal)

Skin, the largest organ of the human body, plays the main role in protecting the body from mechanical damage. It is composed of epidermal, dermal and hypodermal layers. The barrier function of the skin owed to its avascular epidermal layer, which is made mainly of keratinocytes. The keratinocytes form a...
Approved
Matched Description: … of [DB10770] and keratinocytes. ... It is composed of epidermal, dermal and hypodermal layers. ... keratinized, and mostly impermeable outer stratum corneum layer on the surface [L2452]. …

Antithrombin Alfa

Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations.
Approved
Investigational

Modified vaccinia ankara

Modified Vaccinia Ankara (MVA) refers to an attenuated strain of the Vaccinia virus. Vaccines using MVA are live and non-replicating, and are produced using Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN).[L42660,L42670]
Approved
Matched Description: … Vaccines using MVA are live and non-replicating, and are produced using Modified Vaccinia Ankara-Bavarian …

Cerivastatin

On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Canadian market.[A669,L43942]
Approved
Withdrawn
Matched Description: … Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew …

Crotalus atrox antivenin

Each year it is estimated there are 45,000 snakebites in the US and 300,000 to 400,000 bites worldwide. About 8000 of these snakebites involve venomous snake species. The majority of people bitten are males and about 50% occur in the age group of 18 to 28 . Crotalus atrox antivenin...
Approved
Experimental
Matched Description: … Each year it is estimated there are 45,000 snakebites in the US and 300,000 to 400,000 bites worldwide ... isolating the antivenin of interest through fractionation and chromatography techniques. ... The majority of people bitten are males and about 50% occur in the age group of 18 to 28 [F113]. …

Gatifloxacin

Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as...
Approved
Investigational
Withdrawn
Matched Description: … It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. ... Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. ... Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. …

Methyl nicotinate

Methyl nicotinate is the methyl ester of DB00627 that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation. For veterinary purposes, methyl nicotinate is used to...
Approved
Matched Description: … muscle and joint pains [F64]. ... an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and ... methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and …

Isoeugenol

Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. It is also a significant dermatologic sensitizer and allergen, and as a result has been restricted to 200 p.p.m. since 1998 according to guidelines issued by...
Approved
Experimental
Matched Description: … It is also a significant dermatologic sensitizer and allergen, and as a result has been restricted to ... Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally …

Amiodarone

Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone...
Approved
Investigational
Matched Description: … indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and ... Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Aluminum oxide

Aluminum oxide has a chemical formula Al2O3. It is amphoteric in nature, and is used in various chemical, industrial and commercial applications. It is considered an indirect additive used in food contact substances by the FDA.
Approved
Matched Description: … It is amphoteric in nature, and is used in various chemical, industrial and commercial applications. …

Ditiocarb zinc

Ditiocarb zinc, also known as Diethyldithiocarbamic acid zinc salt, is a known chelator for copper and zinc. It also a dermatological sensitizer and allergen. Sensitivity to ditiocarb zinc may be identified with a clinical patch test.
Approved
Matched Description: … It also a dermatological sensitizer and allergen. ... Ditiocarb zinc, also known as Diethyldithiocarbamic acid zinc salt, is a known chelator for copper and …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Tripelennamine

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
Approved
Vet approved
Matched Description: … It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. …

Mipomersen

Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. Mipomersen is indicated in...
Approved
Investigational
Matched Description: … , resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and ... It is marketed under the brand name Kynamro in the United States, and the FDA label includes a black ... Specifically, elevations in the liver enzymes, i.e. transaminases, and in liver fat (hepatic steatosis …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Poractant alfa

Poractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada. It is used to treat Respiratory Distress Syndrome (RDS) in premature infants with an endogenous pulmonary surfactant deficiency. Poractant alfa is an extract of natural porcine lung surfactant consisting of 99% polar lipids (mainly phospholipids)...
Approved
Matched Description: … Poractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada. ... 1% hydrophobic low molecular weight proteins (surfactant associated proteins SP-B and SP-C). ... an extract of natural porcine lung surfactant consisting of 99% polar lipids (mainly phospholipids) and …

Delamanid

Delamanid is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall . It is used in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis (TB) in a combination regimen. Emergence of multidrug-resistant and extensively drug-resistant tuberculosis creates clinical challenges for...
Approved
Investigational
Matched Description: … response to standardized antituberculosis treatments as [DB00951] and [DB01045]. ... It is used in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis (TB) in ... Delamanid is approved by the EMA and is marketed under the trade name Deltyba as oral tablets. …

Trifarotene

Trifarotene is a topical retinoid cream used in the treatment of acne vulgaris that was first approved for use in the United States in October 2019. Retinoids are a class of medications structurally and functionally analogous to vitamin A, though later generation retinoids such as trifarotene and adapalene bear little...
Approved
Investigational
Matched Description: … to vitamin A and are analogous only in function. ... [L9013] Retinoids are a class of medications structurally and functionally analogous to [vitamin A], ... though later generation retinoids such as trifarotene and [adapalene] bear little structural resemblance …
Matched Categories: … Skin and Mucous Membrane Agents …
Displaying drugs 976 - 1000 of 14619 in total