Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Displaying drugs 1051 - 1075 of 15376 in total

Pomalidomide

Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.
Approved
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Triflupromazine

A phenothiazine used as an antipsychotic agent and as an antiemetic.
Approved
Vet approved
Matched Description: … A phenothiazine used as an antipsychotic agent and as an antiemetic. …

Avapritinib

Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the treatment of multidrug resistant cancers. Avapritinib shares a...
Approved
Investigational
Matched Iupac: … (1S)-1-(4-fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin …
Matched Description: … Avapritinib, or BLU-285,[A189327] is a selective tyrosine kinase inhibitor of KIT and platelet derived ... receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and ... Avapritinib was granted FDA approval on 9 January 2020 [L40363] and EMA approval on 24 September 2020 …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Iron sucrose

Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, iron...
Approved
Matched Description: … chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …

Phloxine B

Phloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to products, or as a colorant in dental disclosing tablets. These tablets allow patients to visualise areas where more brushing and...
Approved
Matched Description: … These tablets allow patients to visualise areas where more brushing and flossing are needed. …
Matched Categories: … Indicators and Reagents …

Gadolinium

Gadolinium is under investigation in Hypertension, ACUTE KIDNEY INJURY, and Chronic Kidney Disease. Gadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery Disease.
Approved
Investigational
Matched Description: … Gadolinium is under investigation in Hypertension, ACUTE KIDNEY INJURY, and Chronic Kidney Disease. ... Gadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery …

Nilotinib

Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant...
Approved
Investigational
Matched Iupac: … 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2- …
Matched Description: … A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Galcanezumab

Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin gene-related peptide (CGRP). Although several small-molecule CGRP receptor antagonists have been developed, humanized monoclonal antibodies like galcanezumab are specifically designed to selectively bind to CGRP entities with high potency. Given this target specificity, lack of...
Approved
Investigational
Matched Description: … promising safety and tolerability. ... treatment of migraine and the treatment of episodic cluster headache. ... Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Chikungunya vaccine (live, attenuated)

Chikungunya virus (CHIKV) is a member of the Alphavirus genus that was first identified in Tanzania in 1952. It is spread primarily by the bite of infected mosquitos of the Aedes genus. Infection with CHIKV causes chikungunya fever, an illness characterized by acute fever and severe, persistent arthralgia. Prior to...
Approved
Matched Description: … , Asia, Europe, and the Indian and Pacific Oceans. ... In late 2013, the first cases were identified in the Caribbean, and it has since spread to most of the ... [A262051] Prior to 2013, chikungunya virus cases and outbreaks had been identified in countries in Africa …

Grepafloxacin

Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.
Approved
Investigational
Withdrawn
Matched Iupac: … 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid …
Matched Description: … QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and …

Haloprogin

Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin),...
Approved
Withdrawn
Matched Description: … of yeast membrane structure and function. ... Haloprogin is no longer available in the United States and has been discontinued. ... are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and …

Tannic acid

Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. It acts as a weak acid. Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and other Quercus species). It is removed and used as medicine....
Approved
Matched Iupac: … -(3,4,5-trihydroxybenzoyloxy)benzoyloxy]-2-{[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoyloxy]methyl …
Matched Description: … It is removed and used as medicine. ... urine, painful joints, persistent coughs, and cancer. ... Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and …

Apraclonidine

Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
Approved
Matched Categories: … Antiglaucoma Preparations and Miotics …

Riluzole

A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi.
Approved
Investigational
Matched Description: … A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong …

Pefloxacin

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Approved
Matched Description: … A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Bendamustine

Bendamustine is a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL). Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine...
Approved
Investigational
Matched Iupac: … 4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}butanoic acid …
Matched Description: … a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and ... Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks ... It is active against both active and quiescent cells, although the exact mechanism of action is unknown …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Dapsone

A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of...
Approved
Investigational
Matched Categories: … dapsone and rifampicin ... dapsone, rifampicin and clofazimine …

Pindolol

Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the early 1970s....
Approved
Investigational
Matched Description: … [L32353] Early research into the use of pindolol found it had chronotropic effects, and so further investigation …
Matched Categories: … pindolol and other diuretics …

Nefopam

Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. Nefopam has been investigated for the prevention of Kidney Transplantation.
Approved
Investigational
Matched Iupac: … 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine …
Matched Description: … Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. …

Lumefantrine co-artemether

Lumefantrine Co-Artemether (Riamet) has been investigated for the treatment of Malaria, Malaria, Falciparum, Malaria in Pregnancy, Uncomplicated Malaria, and Uncomplicated Knowlesi Malaria. Lumefantrine Co-Artemether is a tablet formulation of artemether and lumefantrine, a well-tolerated, fast-acting and effective blood schizontocidal drug that serves primarily in the treatment of uncomplicated falciparum malaria...
Approved
Investigational
Matched Description: … the production of free radicals to reduce blood antioxidants and glutathione. ... Lumefantrine Co-Artemether is a tablet formulation of artemether and lumefantrine, a well-tolerated, ... investigated for the treatment of Malaria, Malaria, Falciparum, Malaria in Pregnancy, Uncomplicated Malaria, and …

Fursultiamine

Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative.
Approved
Matched Iupac: … N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(2E)-5-hydroxy-3-{[(oxolan-2-yl)methyl]disulfanyl}pent- …

Pretomanid

Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. Research in recent years has been geared toward the development of novel therapies that target persistent forms of this disease, which have shown resistance to standard therapy...
Approved
Matched Description: … and a cause for significant concern. ... Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality ... It was the first TB drug developed by a nonprofit organization, known as TB Alliance, and was granted …

Perflutren

Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the...
Approved
Matched Description: … The difference in density between the gas-filled bubbles and the blood around them creates an increased ... When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Technetium Tc-99m sestamibi

Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six methoxyisobutylisonitrile (MIBI) ligands, hence the name sesta (6) MIBI.. Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by...
Approved
Investigational
Matched Description: … infarction (non-reversible defects); and 2) evaluating myocardial function and developing information ... intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and ... indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and …
Matched Categories: … Indicators and Reagents …

Tafamidis

Tafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives developed by FoldRX. Tafamidis is structurally similar to diflusinal. Tafamidis was granted an EMA market authorisation on 16 November 2011 and FDA approval on 3 May 2019.
Approved
Investigational
Matched Description: … Tafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives[A27206] developed by FoldRX. ... [A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA approval …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Displaying drugs 1051 - 1075 of 15376 in total