Advanced Filter

Filter by Group

Filter by Market Availability

Displaying drugs 1076 - 1100 of 6866 in total
Eteplirsen is a synthetic antisense oligonucleotide and a phosphorodiamidate morpholino oligomer. It consists of a six-membered morpholino ring replacing the five-membered ribofuranosyl rings found in natural DNA and RNA. Duchenne muscular dystrophy is a rare genetic disorder characterized by progressive muscle deterioration and premature death most commonly due to respiratory...
Approved
Investigational
Matched Synonyms: … ),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonyl)-1-piperazinyl)-N,N-dimethylphosphonamidate ... (P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G …
Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.
Approved
Investigational
Matched Synonyms: … 4-[1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl]benzoic acid ... 4-[1-(5,6,7,8,-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphtalenyl)ethenyl]benzoic acid …
Matched Iupac: … 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid …
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities...
Approved
Matched International brands: … Amlodipine 5 ... Amlodipin-Mepha 5/10 …
Matched Synonyms: … (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate ... 3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate …
Matched Iupac: … 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Salts cas: … 88150-47-4 ... 1239916-29-0 ... 246852-12-0
Matched Mixtures name: … PERAM 4 MG/5 MG TABLET, 30 ADET ... PERAM 4 MG/10 MG TABLET,30 ADET ... AMLOPER 4/5MG FILM KAPLI TABLET, 30 ADET …
Matched Products: … AMLESSA TABLETS 4 mg/ 5mg ... AMLESSA TABLETS 4 mg/ 10mg ... AMTAS-5 TABLET 5 mg …
A benzodiazepine derivative used as an anticonvulsant and hypnotic.
Approved
Matched Synonyms: … 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one ... 2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one ... 7-nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one …
Matched Iupac: … 7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one …
Matched Products: … Nitrazepam-5 ... NITRAZEPAM AL 5 ... NITRADOS TABLET 5 mg …
Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expressed on platelets, vorapaxar prevents thrombin-related platelet aggregation.
Approved
Matched Synonyms: … Ethyl N-[(3R,3aS,4S,4aR,7R,8aR,9aR)-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridyl]vinyl]-3-methyl-1-oxo-3a,4,4a ... [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-Fluorophényl)-2-pyridinyl]vinyl}-1-méthyl-3-oxododécahydronaphto ... Carbamic acid, [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2- pyridinyl]ethenyl]dodecahydro …
Matched Iupac: … ethyl N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-dodecahydronaphtho …
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like...
Approved
Matched Synonyms: … N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl} …
Matched Iupac: … 5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine …
Matched Description: … About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between ... EML4 (echinoderm microtubule-associated protein-like 4) and ALK (anaplastic lymphoma kinase), which …
As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter....
Approved
Matched Synonyms: … 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide ... 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide ... 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide …
Matched Iupac: … 3-{bicyclo[2.2.1]hept-5-en-2-yl}-6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide …
Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Approved
Investigational
Withdrawn
Matched Synonyms: … cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic …
Matched Iupac: … 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline- …
Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. Inhibition of ALK...
Approved
Investigational
Matched Synonyms: … 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3- …
Matched Iupac: … 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-5H,6H,11H-benzo[b]carbazole-3-carbonitrile …
Matched Description: … non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) …
Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine.[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine...
Approved
Investigational
An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
Approved
Matched Synonyms: … 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid ... (±)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid ... 5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione …
Matched Iupac: … 5-(hex-3-yn-2-yl)-1-methyl-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione …
Matched Salts cas: … 309-36-4
Approved
Investigational
Matched Iupac: … {1,26}.0^{3,8}.0^{23,27}.0^{25,42}.0^{32,44}.0^{39,43}.0^{37,45}]heptatetraconta-2(47),3,5,7,27,29(44 ... 2lambda5,9,19,26,43lambda5,44lambda5,45lambda5-heptaaza-15lambda5-phospha-1-cobaltadodecacyclo[27.14.1.1^{1,34}.1^{2,9}.1^{10,13}.0^ …
Matched Mixtures name: … Levomefolate Calcium Pyridoxal-5 Phosphate Mecobalamin Algal ... Levomefolate Calcium, Pyridoxal 5-phosphate, Methylcobalamin and Schizochytrium DHA Oil …
Matched Categories: … Heterocyclic Compounds with 4 or More Rings …
Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment...
Approved
Investigational
Matched Iupac: … 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole …
Matched Categories: … Serotonin 5-HT2 Receptor Agonists …
Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.
Approved
Matched Iupac: … N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine …
Naphazoline is a rapid acting imidazoline sympathomimetic vasoconstrictor of ocular or nasal artierioles[L5804,L5807]. It acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations[L5804,L5807]. Naphazoline was first developed in 1942 as a nasal formulation for congestion .
Approved
Investigational
Matched Iupac: … 2-[(naphthalen-1-yl)methyl]-4,5-dihydro-1H-imidazole …
Matched Salts cas: … 5144-52-5
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Approved
Matched Synonyms: … 5-FU ... 5-Fluoracil ... 5-Fluracil …
Matched Iupac: … 5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione …
Matched Mixtures name: … Actikerall 5 mg/g + 100 mg/g Lösung zur Anwendung auf der Haut …
Matched Products: … 5- FLUOROURACIL. 5% UNGUENTO ... 5-FLUOROURACIL BIOSYN 5 ML 250 MG 10 AMPUL ... INYECCION 5-FU …
Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. It is found within many commercially available cosmetics, lotions, and makeup removers. It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness,...
Approved
Experimental
Matched Synonyms: … 4-Isothiazolin-3-one, 5-chloro-2-methyl- ... 5-Chloro-N-methylisothiazolin-3-one ... 5-Chloro-2-methyl-3(2H)-isothiazolone …
Matched Iupac: … 5-chloro-2-methyl-2,3-dihydro-1,2-thiazol-3-one …
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints . This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals . Allopurinol is a xanthine oxidase enzyme inhibitor that...
Approved
Matched Synonyms: … 4-HPP ... 4-Hydroxypyrazolopyrimidine ... 1H-Pyrazolo(3,4-d)pyrimidin-4-ol …
Matched Iupac: … 1H-pyrazolo[3,4-d]pyrimidin-4-ol …
Matched Salts cas: … 17795-21-0
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
Approved
Matched Synonyms: … 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid …
Matched Iupac: … 5-{3-[(2-carboxy-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid …
Matched Products: … ALLERSOL % 2 GÖZ DAMLASI, 5 ML ... INTAL -5 INHALER 112 DOZ AEROSOL ... OPIDRIN %2 STERIL GOZ DAMLASI, 5 ML …
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Approved
Investigational
Matched Synonyms: … 1,5-bis(4-amidinophenoxy)pentane …
Matched Iupac: … 4-{[5-(4-carbamimidoylphenoxy)pentyl]oxy}benzene-1-carboximidamide …
Levoleucovorin is the enantiomerically active form of Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin). Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro, the levo-isomer has been shown to be...
Approved
Investigational
Matched Synonyms: … N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic ... (6S)-5-formyltetrahydrofolic acid ... (6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid …
Matched Iupac: … (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido …
Matched Description: … Levoleucovorin is the enantiomerically active form of Folinic Acid (also known as 5-formyl tetrahydrofolic ... as the product Fusilev (FDA), has an additional indication for use in combination chemotherapy with 5- …
Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties that carries a risk of agranulocytosis. In biomedical applications, radiolabelled (13C-labeled) aminophenazone has been used in breath tests to measure the cytochrome P-450 metabolic activity in liver function tests. The FDA suspended the use of aminophenazone due to its association...
Approved
Withdrawn
Matched Synonyms: … 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone ... 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one ... 2,3-Dimethyl-4-dimethylamino-1-phenyl-5-pyrazolone …
Matched Iupac: … 4-(dimethylamino)-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one …
Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local...
Approved
Vet approved
Matched Salts cas: … 6108-05-0
Matched Mixtures name: … FIRST AID Contains 101 PIECES ... ARC FIRST AID Contains 101 PIECES ... FIRST AID Contains 101 PIECES HARDCASE …
Matched Products: … LMX 4 KREM %4,5 GR ... LMX 4 KREM %4 5X5 G ... LMX 4 KREM %4 30 GR, 1 ADET …
A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.
Approved
Investigational
Vet approved
Matched Synonyms: … 1-(4-Amino-3,5-dichloro-phenyl)-2-tert-butylamino-ethanol ... 4-amino-α-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol ... 4-amino-3,5-dichloro-α-(((1,1-dimethylethyl)amino)methyl)benzenemethanol …
Matched Iupac: … 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethan-1-ol …
Matched Mixtures name: … AMBROXOL 15 MG+ CLENBUTEROL 10 MCG /5 ML …
In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons.
Approved
Illicit
Investigational
Withdrawn
Matched Iupac: … 2-amino-5-phenyl-4,5-dihydro-1,3-oxazol-4-one …
Displaying drugs 1076 - 1100 of 6866 in total