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Displaying drugs 1426 - 1450 of 14835 in total
4-(Isopropylamino)diphenylamine, also known as IPPD, is a chemical compound commonly used as an antiozonant in rubbers, particularly those used for tires. It is also a known allergen. Sensitivity to this compound may be identified with a clinical patch test.
Approved
Experimental
Matched Synonyms: … N-Isopropyl-N'-phenyl-p-phenylenediamine ... N-Isopropyl-N'-phenyl-1,4-phenylenediamine ... p-Phenylenediamine, N-isopropyl-N'-phenyl
Matched Iupac: … N1-phenyl-N4-(propan-2-yl)benzene-1,4-diamine …
Phenol is an antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Phenol has been used to disinfect skin and to relieve itching. Phenol is also used as an oral analgesic or anesthetic in products...
Approved
Experimental
Matched Synonyms: … Phenyl alcohol ... Phenyl hydroxide …
Matched Description: … Phenol is an antiseptic and disinfectant. ... Phenol has been used to disinfect skin and to relieve itching. ... It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly …
Matched Mixtures name: … Major Camphor and Phenol ... Poison Oak and Ivy ... CAMPHOR (SYNTHETIC) and PHENOL …
Matched Categories: … Phenol and Derivatives ... Antiseptics and Disinfectants …
Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties that carries a risk of agranulocytosis. In biomedical applications, radiolabelled (13C-labeled) aminophenazone has been used in breath tests to measure the cytochrome P-450 metabolic activity in liver function tests. The FDA suspended the use of aminophenazone due to its association...
Approved
Withdrawn
Matched Synonyms: … 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone ... 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one ... 1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone …
Matched Iupac: … 4-(dimethylamino)-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one …
Matched Description: … Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties that carries …
Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also...
Approved
Investigational
Matched Synonyms: … N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea ... 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide …
Matched Iupac: … 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide …
Matched Description: … in tumour cell proliferation and tumour angiogenesis. ... Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. ... It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
A benzodiazepine derivative used as an anticonvulsant and hypnotic.
Approved
Matched Synonyms: … 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one ... 2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one ... 7-nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one …
Matched Iupac: … 7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one …
Matched Description: … A benzodiazepine derivative used as an anticonvulsant and hypnotic. …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Approved
Matched Synonyms: … 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone …
Matched Iupac: … 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one …
Phenylbutyric acid is a fatty acid and a derivative of butyric acid naturally produced by colonic bacteria fermentation. It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting as a chemical chaperone. It is used to treat genetic metabolic syndromes, neuropathies, and urea cycle disorders.[L386,L42105]
Approved
Investigational
Matched Synonyms: … 4-Phenyl-n-butyric acid ... γ-Phenyl-n-butyric acid …
Matched Description: … It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting ... [A249035] It is used to treat genetic metabolic syndromes, neuropathies, and urea cycle disorders. ... Phenylbutyric acid is a fatty acid and a derivative of [butyric acid] naturally produced by colonic bacteria …
Matched Categories: … Alimentary Tract and Metabolism ... sodium phenylbutyrate and ursodoxicoltaurine ... Various Alimentary Tract and Metabolism Products …
A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine.
Approved
Illicit
Matched Synonyms: … 2-phenyl-3-methylmorpholine …
Matched Description: … Its actions and mechanisms are similar to dextroamphetamine. …
Elacestrant is a non-steroidal small molecule and an estrogen receptor (ER) antagonist.[A256838,L44918] In January 2023, it was approved by the FDA for the treatment of ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer.[L44918,L44948] It received a similar approval in the EU in September 2023. Elacestrant binds to estrogen receptor-alpha (ERα)...
Approved
Investigational
Matched Synonyms: … (2R)-2-(2-(ethyl-((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxy-phenyl)tetralin-6-ol ... (6R)-6-(2-(ethyl((4-(2- (ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)- 5,6,7,8-tetrahydronaphthalen ... 2-naphthalenol, 6-(2-(ethyl((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydro …
Matched Iupac: … (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen …
Matched Description: … Elacestrant is a non-steroidal small molecule and an estrogen receptor (ER) antagonist. ... degrader (SERD) thanks to its ability to block the transcriptional activity of the ER and promote its ... [L49334] Elacestrant binds to estrogen receptor-alpha (ERα) and acts as a selective estrogen receptor …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents …
A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
Approved
Illicit
Matched Synonyms: … 1-phenyl-2-diethylamino-1-propanone ... 2-(diethylamino)-1-phenyl-1-propanone …
Matched Categories: … Alimentary Tract and Metabolism …
An ibuprofen-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. It is no longer approved for use in the United States.
Approved
Withdrawn
Matched Synonyms: … 2-(4-(2-Thenoyl)phenyl)propionsäure ... (±)-2-(p-(2-thenoyl)phenyl)propionic acid ... 2-[4-(Thiophene-2-carbonyl)-phenyl]-propionic acid …
Matched Iupac: … 2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid …
Matched Description: … An ibuprofen-type anti-inflammatory analgesic and antipyretic. ... It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like...
Approved
Matched Synonyms: … N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl} …
Matched Iupac: … 5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine …
Matched Description: … lymphoma kinase), which results in constitutive kinase activity that contributes to carcinogenesis and ... autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and ... rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like 4) and
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a heavy and light chain. Talquetamab binds to GPRC5D, a cell surface...
Approved
Investigational
Matched Synonyms: … -KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D)), AND ... ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY, BISPECIFIC ... ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY; BISPECIFIC …
Matched Description: … arm comprising a heavy and light chain. ... It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each ... Talquetamab binds to GPRC5D, a cell surface receptor expressed predominantly on multiple myeloma cells, and
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric...
Approved
Investigational
Matched Synonyms: … N-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4,5-trimethoxybenzamide …
Matched Iupac: … N-({4-[2-(dimethylamino)ethoxy]phenyl}methyl)-3,4,5-trimethoxybenzamide …
Matched Description: … Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. …
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Approved
Investigational
Matched Synonyms: … 5-Phenyl-5-ethylbarbituric acid ... 5-Ethyl-5-phenyl-pyrimidine-2,4,6-trione ... 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione …
Matched Iupac: … 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione …
Matched Description: … It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents …
Matched Mixtures name: … Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide ... Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide …
Matched Categories: … Barbiturates and Derivatives ... Hypnotics and Sedatives ... Phenobarbital and similars ... Metabolic Side Effects of Drugs and Substances …
First synthesized in the early 1980s, itraconazole is a broad-spectrum triazole antifungal agent used to treat a variety of infections. It is a 1:1:1:1 racemic mixture of four diastereomers, made up of two enantiomeric pairs, each possessing three chiral centers. Itraconazole was first approved in the US in 1992 and...
Approved
Investigational
Matched Synonyms: … )-1-PIPERAZINYL)PHENYL)-.DELTA. ... )-1-PIPERAZINYL)PHENYL)-2,4-DIHYDRO-2-(1-METHYLPROPYL)- ... -(4-(P-(((2R*,4S*)-2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL
Matched Iupac: … )piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one ... -[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy}phenyl
Matched Description: … [L50051] Itraconazole was first approved in the US in 1992 [L50056] and is available orally. …
Matched Categories: … Triazole and tetrazole derivatives ... Metabolic Side Effects of Drugs and Substances …
Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients typically display delayed development and neurocognitive impairment.[A214694, A214709, A214712,...
Approved
Illicit
Investigational
Withdrawn
Matched Synonyms: … 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane …
Matched Iupac: … ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine …
Matched Description: … It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity ... Concomitantly with these seizures, patients typically display delayed development and neurocognitive ... it was granted a new FDA approval on June 25, 2020, for treatment of patients with Dravet syndrome and
Matched Categories: … Alimentary Tract and Metabolism …
Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954.
Approved
Vet approved
Matched Synonyms: … 5-Phenyl-5-ethyl-Hexahydropyrimidine-4,6-dione …
Matched Iupac: … 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione …
Matched Description: … [L11112] Primidone was developed by J Yule Bogue and H C Carrington in 1949. ... Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and
Matched Categories: … Barbiturates and Derivatives ... Hypnotics and Sedatives ... Phenobarbital and similars …
Pseudoephedrine is structurally related to ephedrine but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseudoephedrine was described...
Approved
Matched Synonyms: … (+) threo-2-(methylamino)-1-phenyl-1-propanol ... d-psi-2-Methylamino-1-phenyl-1-propanol …
Matched Description: … drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and
Matched Mixtures name: … Up and Up Cold and Sinus ... Up and Up Sinus and Cold D ... Up and Up allergy and congestion relief …
Matched Categories: … Alpha-and Beta-adrenergic Agonists …
Matched Products: … Up and Up Suphedrine ... Up and Up Sinus 12 Hour ... UP AND UP nasal decongestant …
Butoconazole is an imidazole antifungal used in gynecology.
Approved
Matched Synonyms: … 1-[4-(4-Chloro-phenyl)-2-(2,6-dichloro-phenylsulfanyl)-butyl]-1H-imidazole …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning...
Approved
Matched Synonyms: … 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one …
Matched Iupac: … 2-{6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridine]-5'-yl}benzonitrile …
Matched Description: … It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for ... The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and
C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of estradiol to resemble testosterone but less one carbon at the 19 position. It is a schedule III drug in the U.S.
Approved
Illicit
Investigational
Matched Synonyms: … Norandrolone phenyl propionate …
Matched Description: … C18 steroid with androgenic and anabolic properties. …
Matched Categories: … Nandrolone and esters ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. It is typically given to patients who cannot be managed with the standard first line therapy, metformin. Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and...
Approved
Matched Synonyms: … 1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea ... 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide …
Matched Iupac: … 5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide …
Matched Description: … through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and
Matched Mixtures name: … Glyburide and Metformin ... Glyburide and Metformin ... Glyburide and Metformin …
Matched Categories: … Alimentary Tract and Metabolism …
Pyrethrum is the crude extract form obtained from flowers of the plant Chrysanthemum cinerariifolium. Pyrethrin refers to a more refined extract of pyrethrum. While pyrethrum extract is composed of 6 esters, both organic compounds mediate insecticidal activities. Pyrethrum-containing mixtures are used as a common insecticide to control specific pest species....
Approved
Matched Synonyms: … Pyrethrins and pyrethroids …
Matched Description: … Pyrethrum extract is also used used to treat head, body, and pubic lice infections. ... The active compound is absorbed by the lice and destroys them by acting on their nervous systems but …
Matched Mixtures name: … Medi and Lice Lice Killing ... Lice-Nil Lice and Eggs Killer ... Weeks and Leo Complete Lice Treatment …
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were...
Approved
Withdrawn
Matched Synonyms: … [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid …
Matched Iupac: … 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid …
Matched Description: … Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. ... Their well-characterized anti-inflammatory activity, analgesic property, and established safety record …
Displaying drugs 1426 - 1450 of 14835 in total