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Displaying drugs 1501 - 1525 of 1870 in total

Dihydrocodeine

Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of...
Approved
Illicit
Matched International brands: … DF-118 Forte …
Matched Description: … analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and ... It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more …
Matched Mixtures name: … Acetaminophen, Caffeine and Dihydrocodeine Bitartrate ... dihydrocodeine bitartrate and aspirin and caffeine DC ... Dihydrocodeine Bitartrate, Acetaminophen and Caffeine …
Matched Salts name: … Dihydrocodeine phosphate …
Matched Categories: … dihydrocodeine and paracetamol ... dihydrocodeine and acetylsalicylic acid …

Pegaspargase

Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagine through the action of asparagine synthetase. However, leukemia...
Approved
Investigational
Matched Description: … Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine ... amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia ... However, leukemia cells have low levels of this enzyme and depend on exogenous sources. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Enzymes and Coenzymes …
Matched Products: … ONCASPAR POWDER FOR SOLUTION FOR INJECTION/INFUSION 750 U/ML …

Vinflunine

Vinflunine is a third-generation member of the vinca alkaloid family with anti-tumour actions. It was first described in 1998 at the Pierre Fabre research center in France. Like other vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and promotes cell death...
Approved
Investigational
Matched Description: … , [DB00570], and [DB00541] [A31975]. ... vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and ... In murine tumors and human tumor xenografts, vinflunine exhibits an antitumor efficacy than [DB00361] …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Javlor Concentrate for Solution for Infusion 25 mg/mL …

Avelumab

Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. Avelumab was first approved by the FDA on March 23, 2017. On September 18 and December 18 of the same year,...
Approved
Investigational
Matched Description: … ] and Health Canada,[L48171] respectively. ... programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and ... [A261496] On September 18 and December 18 of the same year, it was also granted approval by EMA [L48126 …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … BAVENCIO CONCENTRATE FOR SOLUTION FOR INFUSION 200MG/10ML …

Natalizumab

Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA reintroduced the drug to the...
Approved
Investigational
Matched Description: … In 2006, the FDA reintroduced the drug to the market for multiple sclerosis. ... [A261326] Natalizumab was further approved by the FDA for the treatment of Crohn's Disease in January …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Tysabri Concentrate for Solution for Infusion 300mg/15ml …

Idursulfase

Idursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. Idursulfase is produced by recombinant DNA technology in a human cell line. Idursulfase is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and heparan sulfate in the lysosomes of various...
Approved
Matched Description: … -sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and ... Idursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Matched Products: … ELAPRASE SOLUTION FOR INTRAVENOUS INFUSION ... Elaprase (TM) Solution for Intravenous Infusion 2mg/ ml …

Nivolumab

Nivolumab is a fully human IgG4 antibody targeting the immune checkpoint programmed death receptor-1 (PD-1). This antibody was produced entirely in mice and grafted onto human kappa and IgG4 Fc region with the mutation S228P for additional stability and reduced variability. It was developed by Bristol Myers Squibb. Nivolumab was...
Approved
Matched Description: … with the mutation _S228P_ for additional stability and reduced variability. ... [L12129] This antibody was produced entirely in mice and grafted onto human kappa and IgG4 Fc region …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... nivolumab and relatlimab ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … Opdivo 10mg/ml, Concentrate for solution for infusion ... OPDIVO CONCENTRATE FOR SOLUTION FOR INFUSION 10 MG/ML ... NIVOLUMAB BMS CONCENTRATE FOR SOLUTION FOR INFUSION 10MG/ML …

Remdesivir

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends on an RNA-dependent RNA polymerase...
Approved
Investigational
Matched Description: … the related SARS-CoV and MERS-CoV,[A222398] and has been investigated in multiple COVID-19 clinical ... disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and ... , A222393] Broad antiviral activity of remdesivir is suggested by its mechanism of action,[A222398] and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Nucleosides and Nucleotides ... Nucleic Acids, Nucleotides, and Nucleosides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors ... Antivirals for Systemic Use …
Matched Products: … COVIFOR (REMDESIVIR FOR INJECTION 100MG/VIAL) ... VEKLURY® LYOPHILIZED POWDER FOR IV INFUSION 100MG/VIAL …

Rituximab

Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences , [FDA label]. It was originally...
Approved
Matched Description: … sequences and human constant region sequences [A40017], [FDA label]. ... chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and ... The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region …
Matched Categories: … Amino Acids, Peptides, and Proteins ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES ... Biologics for Rheumatoid Arthritis Treatment …
Matched Products: … Mabthera Vials 10mg/ml Concentreate For Solution For Infusion ... TRUXIMA® CONCENTRATE FOR SOLUTION FOR INFUSION 10MG/ML ... Mabthera Concentrate for Solution for Infusion 100mg/10ml …

Carfilzomib

Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.
Approved
Investigational
Matched Description: … Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. ... FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … KYPROLIS POWDER FOR SOLUTION FOR INFUSION 60MG/VIAL ... KYPROLIS POWDER FOR SOLUTION FOR INFUSION 30 MG/VIAL ... Kyprolis (carfilzomib) powder for solution for infusion 60mg/vial …

Blinatumomab

Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostly expressed on the surface of...
Approved
Investigational
Matched Description: … promotes tumor cell lysis and apoptosis. ... recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through ... acute lymphoblastic leukemia (ALL) in relapsed and refractory patients. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … BLINCYTO POWDER FOR INFUSION 35 MCG/VIAL ... BLINCYTO (Blinatumomab) for injection 35 mcg/vial …

Thyrotropin alfa

Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of...
Approved
Vet approved
Matched Description: … linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and ... similarity with the alpha subunit of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and ... It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Anterior Pituitary Lobe Hormones and Analogues ... Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Thyrogen 0.9 mg Powder for Solution for Injection …

Idarucizumab

Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and inactivates the oral anticoagulant dabigatran, thereby reversing its anticoagulant effect. As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran includes bleeding, espeically when...
Approved
Matched Description: … monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and ... Its use is associated with immediate, complete and sustained reversal of the anticoagulant effects of ... Approved under the tradename Praxbind (FDA), idarucizumab is indicated for the emergency treatment of …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … PRAXBIND Solution for Injection/Infusion 50 mg/ml ... PRAXBIND SOLUTION FOR INJECTION/INFUSION 50 MG/ML …

Artesunate

Artesunate is indicated for the initial treatment of severe malaria. The World Health Organization recommends artesunate as first line treatment for severe malaria. Artesunate was developed out of a need for a more hydrophilic derivative of artemisinin. Artesunate was granted FDA approval on 26 May 2020.
Approved
Investigational
Matched Description: … Artesunate is indicated for the initial treatment of severe malaria. ... [L890] Artesunate was developed out of a need for a more hydrophilic derivative of [artemisinin]. ... [L14099] The World Health Organization recommends artesunate as first line treatment for severe malaria …
Matched Salts name: … Artesunate sodium …
Matched Categories: … Artemisinin and derivatives ... Antiparasitic Products, Insecticides and Repellents ... artesunate and mefloquine ... artesunate and amodiaquine ... artesunate and pyronaridine …
Matched Products: … ARTESUNATE FOR INJECTION ... ARTESUN POWDER FOR INJECTION 60 MG …

Fulvestrant

Fulvestrant is a drug treatment of hormone receptor (HR)-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. While it is used as monotherapy for the...
Approved
Investigational
Matched Description: … It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and ... While it is used as monotherapy for the treatment of breast cancers, it is also used in combination with ... [alpelisib] for the treatment of HR-positive, human epidermal growth factor receptor 2 (HER2)-negative …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … FASLODEX SOLUTION FOR INJECTION 250MG/5 ML ... FEMCORD SOLUTION FOR INJECTION 250 MG/5 ML ... Faslodex Solution For Injection 250 mg/5ml …

Choriogonadotropin alfa

Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical...
Approved
Matched Description: … O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER ... -121, SER-127, SER-132 and SER-138 (on beta subunit). ... human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gonadotropins and Antigonadotropins ... Sex Hormones and Modulators of the Genital System …
Matched Products: … Ovidrel Solution for Injection 250 mcg ... OVIDREL 250MCG/0.5ML SOLUTION FOR INJECTION …

[2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid

Experimental
Matched Name: … [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid …

(2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE

Experimental
Matched Name: … (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE …

Eribulin

Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for use in the treatment of...
Approved
Investigational
Matched Description: … who have previously received at least two chemotherapeutic regimens for the treatment of metastatic ... Eribulin is also being investigated for use in the treatment of advanced solid tumors [A7439]. ... Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … HALAVEN 0.5 mg/ml solution for injection ... Halaven Solution for Injection 0.5mg/mL …

Isavuconazole

Isavuconazole is an triazole antifungal with broad spectrum of activity and good safety profile . It is approved by the FDA and EMA for the treatment of invasive aspergillosis and mucormycosis. It works by inhibiting fungal cell membrane synthesis. Invasive fungal infections pose significant clinical challenges for patients, especially those...
Approved
Investigational
Matched Description: … It is approved by the FDA and EMA for the treatment of invasive aspergillosis and mucormycosis. ... Isavuconazonium displays excellent water solubility for intravenous formulations, good absorption, and ... Cresemba for the treatment of invasive aspergillosis and mucormycosis as oral or intravenous administration …
Matched Categories: … Isavuconazole and Prodrugs ... Triazole and tetrazole derivatives ... Antimycotics for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … CRESEMBA (POWDER FOR SOLUTION FOR CONCENTRATE FOR SOLUTION FOR INFUSION 200 MG/VIAL) …

Racecadotril

Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
Investigational
Matched Description: … Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …
Matched Products: … Hidrasec Infants 10mg Granules for Oral Suspension ... Hidrasec Children 30mg Granules for Oral Suspension ... Hidrasec Infants Granules for Oral Suspension 10mg …

Letermovir

Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients. It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors. Letermovir has recieved both priority and orphan drug status...
Approved
Investigational
Matched Description: … [A31290] Letermovir has recieved both priority and orphan drug status from the FDA. ... Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … PREVYMIS CONCENTRATE FOR SOLUTION FOR INFUSION 20MG/ML ... PREVYMIS 240mg/12mL (20mg/mL) concentrate for solution for infusion ... PREVYMIS 480mg/24mL (20mg/mL) concentrate for solution for infusion …

2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid

Experimental
Matched Name: … 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid …

Ixekizumab

Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflammatory conditions. In particular, IL-17A has...
Approved
Investigational
Matched Description: … heavy chain polypeptides of 445 amino acids each, and has a molecular weight of 146,158 Daltons for ... humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and ... As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Skin and Mucous Membrane Agents …
Matched Products: … Taltz 80mg solution for injection in pre-filled pen ... Taltz 80mg solution for injection in pre-filled syringe ... TALTZ SOLUTION FOR INJECTION IN PRE-FILLED PEN 80 mg/ml …

Satralizumab

Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to tocilizumab, which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune inflammatory disorder of the central...
Approved
Matched Description: … [A218551] It received subsequent approvals in Switzerland and Japan,[A218551] and was approved for use ... [A218551] Some of the pro-inflammatory mechanisms involved in NMOSD are thought to be mediated, at least ... interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … ENSPRYNG SOLUTION FOR INJECTION IN PREFILLED SYRINGE 120MG/1ML ... ENSPRYNG 120 mg/1ml solution for injection in pre-filled syringe …
Displaying drugs 1501 - 1525 of 1870 in total