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Displaying drugs 1 - 25 of 88 in total

Nicorandil

Nicorandil is an orally efficacious vasodilatory drug and antianginal agent marketed in the UK, Australia, most of Europe, India, Philippines, Japan, South Korea, and Taiwan. It is not an approved drug by FDA. It is a niacinamide derivative that induces vasodilation of arterioles and large coronary arteries by activating potassium...
Approved
Investigational
Matched Synonyms: … 2-Nicotinamidoethyl nitrate ... N-(2-Hydroxyethyl)nicotinamide nitrate ... N-(2-Hydroxyethyl)nicotinamide nitrate (ester) …
Matched Iupac: … 2-[(pyridin-3-yl)formamido]ethyl nitrate …
Matched Description: … Nicorandil is a dual-action potassium channel opener that relaxes vascular smooth muscle through membrane ... niacinamide derivative that induces vasodilation of arterioles and large coronary arteries by activating potassium ... hyperpolarization via increased transmembrane potassium conductance and increased intracellular concentration …
Matched Categories: … Potassium Channel Opener …

Isosorbide dinitrate

A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Approved
Investigational
Matched Synonyms: … Sorbide nitrate …
Matched Iupac: … (3R,3aS,6S,6aS)-6-(nitrooxy)-hexahydrofuro[3,2-b]furan-3-yl nitrate …
Matched Categories: … Nitrate Vasodilator …

Pilocarpine

A naturally occurring alkaloid derived from the Pilocarpus plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, including elevated intraocular pressure and glaucoma. The usage of glaucoma by...
Approved
Investigational
Matched Salts name: … Pilocarpine nitrate …
Matched Products: … Minims Pilocarpine Nitrate ... Minims Pilocarpine Nitrate 4% ... MINIMS PILOCARPINE NITRATE EYE DROPS 2% w/v …

Octasulfur

Sulfur is a chemical element that is present in all living tissues. The most commonly used form of pharmaceutical sulfur is Octasulfur (S8). After calcium and phosphorus, it is the third most abundant mineral in the human body. Sulfur is also found in garlic, onions and broccoli. People take sulfur...
Approved
Matched Description: … After calcium and phosphorus, it is the third most abundant mineral in the human body. …
Matched Mixtures name: … Calcium Magnesium Sulfur Silicon - Tab ... Sulfacetamide Sodium Sulfur ... sulfacetamide sodium and sulfur Sodium Sulfacetamide - Sulfur …
Matched Products: … Sodium Sulfacetamide and Sulfur ... SLMD Silver Sulfur Acne Cream …

Sulindac

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted in vivo...
Approved
Investigational
Matched Description: … compound by liver enzymes. ... Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide ... This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant …
Matched Salts name: … Sulindac sodium …

Bismuth subsalicylate

Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of salicylic acid linked to trivalent bismuth cation. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth subsalicylate has been around for over 100 years: it...
Approved
Vet approved
Matched Mixtures name: … Bismuth Tablets With Calcium Carbonate ... Chewable Bismuth Tablets With Calcium Carbonate …

Montelukast

Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montelukast is typically in addition to or...
Approved
Matched Salts name: … Montelukast sodium …
Matched Categories: … Hydrogen Sulfide …
Matched Products: … Montelukast Sodium ... Montelukast sodium ... Montelukast sodium chewable …

Azathioprine

Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of...
Approved
Matched Salts name: … Azathioprine sodium …
Matched Products: … Azathioprine Sodium ... Azathioprine Sodium for Injection …

Cilastatin

Cilastatin is an inhibitor of renal dehydropeptidase, an enzyme responsible for both the metabolism of thienamycin beta-lactam antibiotics as well as conversion of leukotriene D4 to leukotriene E4. Since the antibiotic, imipenem, is one such antibiotic that is hydrolyzed by dehydropeptidase, cilastatin is used in combination with imipenem to prevent...
Approved
Investigational
Matched Mixtures name: … IMIPENEM MONOHYDRATE - CILASTATIN SODIUM ... IMIPENEM MONOHYDRATE / CILASTATIN SODIUM …
Matched Salts name: … Cilastatin sodium …
Matched Products: … Cilastatin Sodium Sterile …

Ubidecarenone

Ubidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of isoprenyl subunits in its tail. It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation. The ubidecarenone is...
Approved
Investigational
Nutraceutical

Thiamine

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays...
Approved
Investigational
Nutraceutical
Vet approved
Matched Description: … It is essential for normal growth and development and helps to maintain proper functioning of the heart …
Matched Mixtures name: … Chela Potassium Plus ... Twin Ultra Liquid Fruit Punch Flavor ... Phytofortis + Calcium A-D …

Cystine

A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Approved
Nutraceutical
Matched Categories: … Hydrogen Sulfide …

Cysteine

A thiol-containing non-essential amino acid that is oxidized to form cystine.
Approved
Nutraceutical

Pergolide

Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome....
Approved
Investigational
Vet approved
Withdrawn

Ticagrelor

Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism. Unlike clopidogrel, ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU, . Ticagrelor was...
Approved

Nicotinamide

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Approved
Investigational
Matched Mixtures name: … MEDIUS Heart Ppyoung Ppyoung Eye ... Chela Potassium Plus ... Twin Ultra Liquid Fruit Punch Flavor …

Trabectedin

Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate Ecteinascidia turbinata and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair...
Approved
Investigational

Sodium sulfide

Sodium sulfide is a chemical compound with a chemical formula Na2S. Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various chemical manufacturing processes including the production of rubber chemicals, sulfur dyes and oil recovery. Along with its hydrate form, sodium sulfide releases hydrogen...
Approved
Matched Name: … Sodium sulfide …
Matched Description: … Sodium sulfide is a chemical compound with a chemical formula Na2S. ... Along with its hydrate form, sodium sulfide releases hydrogen sulfide (H2S) when in contact with moist ... Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various …
Matched Categories: … Hydrogen Sulfide …
Matched Products: … Sodium Sufide …

Erythrityl tetranitrate

A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)
Approved
Experimental
Investigational
Matched Iupac: … (2R,3S)-1,3,4-tris(nitrooxy)butan-2-yl nitrate …

Sulconazole

Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream and solution. Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for tinea cruris and tinea corporis infections.[L44592,L44597] Sulconazole appears to be effective...
Approved
Matched Description: … Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common …
Matched Salts name: … Sulconazole nitrate …
Matched Products: … Sulconazole Nitrate …

Thiosulfuric acid

Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate. Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has a variety of industrial uses, including food preservative, water de-chlorinator and paper pulp bleaching agent. Sodium thiosulfate is rapidly degraded...
Approved
Investigational
Matched Description: … Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate ... Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has ... Sodium thiosulfate is also used to reduce the risk of ototoxicity associated with [cisplatin]. …
Matched Mixtures name: … Sodium Polysulthionate, 5-mthf ... Sodium polysulthionate and folic acid ... Sodium Polysulthionate and Folic Acid …
Matched Salts name: … Sodium thiosulfate ... Sodium thiosulfate pentahydrate …
Matched Products: … Sodium Thiosulfate ... Sodium Thiosulfate Inj 25% USP ... Sodium Thiosulfate Injection USP …

Latanoprostene bunod

Latanoprostene Bunod has been used in trials studying the treatment of Glaucoma, Ocular Hypertension, Open-Angle Glaucoma, Open Angle Glaucoma, and Intraocular Pressure. As of November 2, 2017 the FDA approved Bausch + Lomb's Vyzulta (latanoprostene bunod opthalmic solution), 0.024% for the indication of reducing intraocular pressure in patients with open-angle...
Approved
Investigational

Dimethyl sulfoxide

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including...
Approved
Vet approved

Cimetidine

A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Products: … Cimetidine in Sodium Chloride …

Axitinib

Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times higher than that of the first generation...
Approved
Investigational
Displaying drugs 1 - 25 of 88 in total