Displaying all 14 targets
E3 ubiquitin-protein ligase Mdm2
Matched Polypeptides name: … E3 ubiquitin-protein ligase Mdm2 …
Matched Polypeptides synonyms: … Oncoprotein Mdm2 ... p53-binding protein Mdm2 …
Matched Polypeptides specific function: … Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. ... Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response …
Matched Name: … E3 ubiquitin-protein ligase Mdm2 …
Matched Polypeptides synonyms: … Oncoprotein Mdm2 ... p53-binding protein Mdm2 …
Matched Polypeptides specific function: … Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. ... Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response …
Matched Name: … E3 ubiquitin-protein ligase Mdm2 …
E3 ubiquitin-protein ligase TRIM13
Matched Polypeptides specific function: … and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. ... Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 …
Ubiquitin-conjugating enzyme E2 D2
Matched Polypeptides specific function: … conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2 …
Bis(5'-adenosyl)-triphosphatase
Matched Polypeptides specific function: … Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated …
Serine/threonine-protein kinase Sgk1
Matched Polypeptides specific function: … Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. …
Mitogen-activated protein kinase 7
Matched Polypeptides general function: … Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. …
Serine-protein kinase ATM
Matched Polypeptides specific function: … Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination …
Serine/threonine-protein kinase Chk2
Matched Polypeptides specific function: … Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation …
Focal adhesion kinase 1
Matched Polypeptides specific function: … Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity …
Protein-tyrosine kinase 2-beta
Matched Polypeptides specific function: … Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity …
Extracellular signal-regulated kinase (ERK)
Matched Polypeptides general function: … Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. …
Protein PML
Matched Polypeptides general function: … acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2 …
Mitogen-activated Protein Kinases
Matched Polypeptides general function: … Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. …
NAD-dependent protein deacetylase sirtuin-1
Matched Polypeptides specific function: … oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 …
Displaying all 14 targets