Hyperammonaemia (DBCOND0013194)

Identifiers

Synonyms

Hyperammonemia / Disorder of urea cycle metabolism, unspecified / Hyperammonemia (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Arginine	An amino acid commonly found as a component of total parenteral nutrition.	Cationic amino acid transporter 3target Antizyme inhibitor 2target Argininosuccinate lyasetarget Nitric oxide synthase, inducibletarget High affinity cationic amino acid transporter 1target Arginase-2, mitochondrialtarget Cationic amino acid transporter 4target Argininosuccinate synthasetarget Nitric oxide synthase 3target Organic cation/carnitine transporter 2transporter Monocarboxylate transporter 10transporter Solute carrier family 22 member 4transporter
Arginine glutamate	Two amino acids indicated in the treatment of hyperammonemia and in combination for total parenteral nutrition.	No drug targets
Phenylacetic acid	An agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle.	Liver carboxylesterase 1enzyme
Potassium aspartate	A potassium supplement used to treat hypokalemia or hyperammonemia.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05040178	An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics	Carglumic acid	Not Available	Not Available	recruiting
NCT06178718	A Phase 1, Single-center, Double-blind, Placebo-controlled Study of TNP-2092 Capsules, and the Food Effect Study After Single-dose Oral Administration of TNP-2092 Capsules	TNP-2092	treatment	1	completed
NCT03947034	Monitoring the Hyperammonaemia:TOXicity of Drugs (AmmoTOX)	No drug interventions	Not Available	Not Available	completed
NCT00279851	Blood Sugars in Children With Idiopathic Seizures.	No drug interventions	Not Available	Not Available	withdrawn
NCT06135675	Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of TNP-2092 Capsules in Liver Cirrhosis Patients With Hyperammonemia	TNP-2092	treatment	1 / 2	completed
NCT05349435	A Healthy Volunteer Study to Compare Fezagepras (PBI-4050) With Sodium Phenylbutyrate	Phenylbutyric acid Setogepram	treatment	1	terminated
NCT05842837	A Non-Interventional Post-Authorization Study of Carbaglu for the Treatment of Hyperammonemia Due to MMA and PA	Carglumic acid	Not Available	Not Available	enrolling_by_invitation