Visceral Leishmaniasis (DBCOND0033119)

Identifiers

Synonyms
Leishmaniasis, Visceral / Visceral leishmaniasis / Leishmaniasis visceral (kala-azar) / Dumdum fever / Visceral leishmaniasis (disorder) / Kala-azar / Leishmania donovani infection / Post-kala-azar dermal leishmaniasis (disorder) / Post kala-azar dermal leishmaniasis

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Amphotericin B
An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
Miltefosine
An antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type.
Sodium stibogluconate
For the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment...
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00318721
Efficacy, Acceptability and Cost-effectiveness of Long Lasting Insecticide Nets (LLIN) in the Prevention of Kala AzarNo drug interventionspreventionNot Availablecompleted
NCT01138956
Immune Response of Visceral Leishmaniasis PatientsTreated With Antimonial Plus N-Acetylcysteinebasic_scienceNot Availableunknown_status
NCT04342715
A Study to Assess Immune Response Status in Patients Before and After Treatment for Visceral LeishmaniasisNot AvailableNot Availablerecruiting
NCT01980199
Trial to Determine Efficacy of Fexinidazole in Visceral Leihmaniasis Patients in Sudantreatment2terminated
NCT03269006
Improved Case Detection and Vector Control for Visceral LeishmaniasisNo drug interventionspreventionNot Availablecompleted
NCT00628719
Single Infusion of Liposomal Amphotericin B in Indian Visceral Leishmaniasistreatment3completed
NCT02071758
Phase 1 LEISH-F3 + SLA-SE Vaccine Trial in Healthy Adult Volunteersprevention1completed
NCT02011958
Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients.treatment3completed
NCT02148822
Visceral Leishmaniasis and Malnutrition in Amhara Regional State, EthiopiaNo drug interventionsNot AvailableNot Availablecompleted
NCT01766830
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)No drug interventionsdiagnosticNot Availablecompleted
NCT00486382
Open-Label Safety Study of Three-Antigen Leishmania Polyprotein With Adjuvant MPL-SE in Healthy Adults in IndiaNo drug interventionstreatment1completed
NCT01240473
A Pilot Study for Capacity Building for a Multi-centre, Randomized Trial for Treatment of Kala Azar in BangladeshNo drug interventionstreatmentNot Availablecompleted
NCT00255567
Efficacy/Safety of Sodium Stibogluconate (SSG) Versus Paromomycin (PM) and SSG/PM Combination to Treat V Leishmaniasistreatment3completed
NCT00696969
Safety and Efficacy Study to Evaluate Different Combination Treatment Regimens for Visceral Leishmaniasistreatment3completed
NCT00604955
Expand Access/Assess Safety and Efficacy of Paromomycin IM Injection for the Treatment of Visceral Leishmaniasistreatment4completed
NCT00342823
Immunogenetics of Visceral LeishmaniasisNo drug interventionsNot AvailableNot Availablecompleted
NCT00832208
Open-Label, Sequential Step, Safety and Efficacy Study to Determine the Optimal Single Dose of Ambisome for Patients With VLtreatment2terminated
NCT01310738
Efficacy and Safety Study of Drugs for Treatment of Visceral Leishmaniasis in Braziltreatment4terminated
NCT02431143
Pharmacokinetics/Safety of Miltefosine Allometric Dose for the Treatment of Visceral Leishmaniasis in Children in Eastern Africatreatment2completed
NCT02839603
Asymptomatic Leishmania Infection in HIV PatientsNo drug interventionsNot AvailableNot Availableterminated
NCT01032187
Amphotericin B to Treat Visceral Leishmaniasis in Brazilian Childrentreatment4completed
NCT05426577
Evaluation of Less Invasive Procedures for Visceral Leishmaniasis Treatment Efficacy Monitoring Test of CureNo drug interventionsNot AvailableNot Availableunknown_status
NCT01069198
A Community Trial for Visceral Leishmaniasis (VL)preventionNot Availablecompleted
NCT00310505
Amphotericin B Treatment in Visceral LeishmaniasisNo drug interventionstreatmentNot Availablecompleted
NCT01122771
Phase III, Study of Three Short Course Combo (Ambisome®, Miltefosine, Paromomycin) Compared With AmBisome for the Treatment of VL in Bangladeshtreatment3completed
NCT04003532
LAMP Assay for the Diagnosis of Visceral LeishmaniasisNo drug interventionsNot AvailableNot Availablecompleted
NCT01566552
Single Dose Liposomal Amphotericin B for Visceral Leishmaniasistreatment4unknown_status
NCT03636659
Steady State Global Bioequivalence Study of Amphotericin B Liposome for Injection 50 mg/ Vial in Fed Conditiontreatment1completed
NCT05386875
Evaluation to Assess the Usability of rK28 for the Diagnosis of Visceral Leishmaniasis in KenyaNo drug interventionsNot AvailableNot Availablerecruiting
NCT06118749
Leishmania Antigen Rapid Diagnostic Test Proof-of-Concept and Validation StudyNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03929016
Single Oral Dose Escalation Study of DNDI-0690 in Healthy SubjectsNo drug interventionstreatment1completed
NCT00370825
Combination Chemotherapy for the Treatment of Indian Kala-Azartreatment2completed
NCT01328457
An Effectiveness Study of Paromomycin IM Injection (PMIM) for the Treatment of Visceral Leishmaniasis (VL) in BangladeshtreatmentNot Availablecompleted
NCT00629031
An Open Lable Randomised Study to Assess the Safety and Efficacy of Short Course Paromomycin in Visceral Leishmaniasistreatment3completed
NCT01360762
Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Studyprevention3completed
NCT00497601
A Phase II Study To Assess Safety and Efficacy Of Short-Course Regimens Of Amphotericin B Emulsion In Kala-Azartreatment2completed
NCT03129646
Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africatreatment3completed
NCT00216346
Safety and Efficacy Study of Paromomycin to Treat Visceral Leishmaniasistreatment3completed
NCT05602610
Clinical Prognostic Score to Predict Relapse in VLNo drug interventionsNot AvailableNot Availablerecruiting
NCT00371995
Short Course of Miltefosine and Liposomal Amphotericin B for Kala-azartreatment2completed
NCT03646981
Evaluation of Antibody Detection Tests for Visceral Leishmaniasis Diagnosis in Eastern AfricaNo drug interventionsNot AvailableNot Availablecompleted
NCT05449717
Incidence of Relapse and Post-Kala-Azar Dermal Leishmaniasis in South SudanNo drug interventionsNot AvailableNot Availablerecruiting
NCT00876824
To Study the Effect Of Single Infusions Of Amphotericin B Lipid Preparations in Treatment of Patients Of Kala Azartreatment3completed
NCT00523965
Combination Therapy in Indian Visceral Leishmaniasistreatment3completed
NCT03013673
Predicting Visceral Leishmaniasis in HIV Infected PatientsNo drug interventionsNot AvailableNot Availableterminated
NCT00381394
A Study Evaluating Sitamaquine Compared With Amphotericin B In The Treatment Of Visceral Leishmaniasis.treatment2completed
NCT00001169
Clinical Investigation of Infections Due to Leishmanial ParasitesNo drug interventionsNot AvailableNot Availablecompleted