Estrogen Receptor Positive Breast Cancer (DBCOND0049177)

Identifiers

Synonyms
Estrogen Receptor-Positive Breast Cancer / Estrogen-receptor-positive Breast Cancer / ER+ Breast Cancer / Estrogen-receptor Positive Breast Cancer / Oestrogen receptor positive breast cancer / Breast Cancer, Estrogen Receptor-Positive / ER Positive Breast Cancer / ER-positive Breast Cancer / Estrogen receptor positive breast cancer / Hormone receptor positive breast cancer

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01037790
Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With CancerNo drug interventionstreatment2completed
NCT03768479
The Value of 18F-FES-PET/CT in Predicting Fulvestrant Efficacy in Breast CancerNo drug interventionsotherNot Availableunknown_status
NCT02235051
Exercise Intervention in Preventing Breast Cancer Recurrence in Postmenopausal Breast Cancer SurvivorsNo drug interventionspreventionNot Availablecompleted
NCT03962647
A 2-Week Ketogenic Diet in Combination With Letrozole to Modulate PI3K Signaling in ER+ Breast Cancertreatment0active_not_recruiting
NCT01394211
Neo-adjuvant Therapy With Anastrozole Plus Pazopanib in Stage II and III ER+ Breast Cancertreatment2terminated
NCT06439693
The SAPPHO Study: A Single-Arm, Phase II Study of Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancertreatment2not_yet_recruiting
NCT02273752
Pharmacokinetically Guided Everolimus in Patients With Breast Cancer, Pancreatic Neuroendocrine Tumors, or Kidney Cancertreatment2terminated
NCT02015559
Mucoadhesive Oral Wound Rinse in Preventing and Treating Stomatitis in Patients With ER- or PR-Positive Metastatic or Locally Recurrent Breast Cancer That Cannot be Removed by Surgery Receiving EverolimusNo drug interventionssupportive_care2completed
NCT01339442
BKM120 and Fulvestrant for Treating Postmenopausal Patients With Estrogen Receptor-Positive Stage IV Breast Cancertreatment1completed
NCT00003199
Combination Chemotherapy and Peripheral Blood Stem Cell Transplant Followed By Aldesleukin and Sargramostim in Treating Patients With Inflammatory Stage IIIB or Metastatic Stage IV Breast Cancertreatment2completed
NCT01824836
A Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS)supportive_careNot Availableactive_not_recruiting
NCT00057941
Anastrozole and ZD1839 Compared With Fulvestrant and ZD1839 in Postmenopausal Women w/ Metastatic Breast Cancertreatment2completed
NCT01208441
RO4929097 and Letrozole in Treating Post-Menopausal Women With Hormone Receptor-Positive Stage II or Stage III Breast Cancertreatment1terminated
NCT01368263
Goserelin and Letrozole or Anastrozole in Premenopausal Patients With Stage II-III Estrogen Receptor-Positive Breast Cancertreatment2terminated
NCT00676663
Study to Evaluate Exemestane With and Without Entinostat (SNDX-275) in Treatment of Postmenopausal Women With Advanced Breast CancerNo drug interventionstreatment2completed
NCT03633331
Palbociclib and Letrozole or Fulvestrant in Treating Patients With Estrogen Receptor Positive, HER2 Negative Metastatic Breast Cancertreatment2unknown_status
NCT00952731
4-Hydroxytamoxifen or Tamoxifen Citrate in Treating Women With Newly Diagnosed Ductal Breast Carcinoma in SituNo drug interventionstreatment2completed
NCT05020860
Correlation of Clinical Response to Pathologic Response in Patients With Early Breast Cancertreatment2recruiting
NCT04597580
Personalised Disease Monitoring in Metastatic Breast CancerNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01385280
Pilot Study Estradiol Followed by Exemestane Hormone Receptor + Metastatic Breast CancertreatmentNot Availablecompleted
NCT02957968
Neoadjuvant Pembrolizumab + Decitabine Followed by Std Neoadj Chemo for Locally Advanced HER2- Breast CaNo drug interventionstreatment2active_not_recruiting
NCT00082810
Tipifarnib and Fulvestrant in Hormone Receptor-Positive Metastatic Breast Cancertreatment2completed
NCT00602043
F-18 16 Alpha-Fluoroestradiol-Labeled Positron Emission Tomography in Predicting Response to First-Line Hormone Therapy in Patients With Stage IV Breast CancerNo drug interventionsdiagnostic2completed
NCT00194779
Combination Chemotherapy and Filgrastim Before Surgery in Treating Patients With HER2-Positive Breast Cancer That Can Be Removed By Surgerytreatment2completed
NCT01409811
Biomarkers in Tissue Samples From Patients With Newly Diagnosed Breast Cancer Treated With Zoledronic AcidNo drug interventionstreatmentNot Availableterminated
NCT01791478
BYL719 and Letrozole in Post-Menopausal Patients With Hormone Receptor-Positive Metastatic Breast CancerNo drug interventionstreatment1active_not_recruiting
NCT04965688
Systems Biology Guided Therapy for Breast Cancer Positive for Oestrogen Receptor After Aromatase Inhibitor and CDK InhibitionNo drug interventionstreatment2recruiting
NCT01953588
Fulvestrant and/or Anastrozole in Treating Postmenopausal Patients With Stage II-III Breast Cancer Undergoing SurgeryNo drug interventionstreatment3active_not_recruiting
NCT00407888
Doxorubicin Hydrochloride, Cyclophosphamide, and Filgrastim Followed By Paclitaxel Albumin-Stabilized Nanoparticle Formulation With or Without Trastuzumab in Treating Patients With Breast Cancer Previously Treated With SurgeryNo drug interventionstreatment2completed
NCT04571437
Letrozole and Metronomic Capecitabine in ER-positive HER2 Negative Advanced Breast Cancer (B-001 Study)No drug interventionstreatment2unknown_status
NCT02186470
Intensity Modulated Accelerated Partial Breast Irradiation Before Surgery in Treating Older Patients With Hormone Responsive Stage 0-I Breast CancerNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02269670
Phase II Study of Everolimus Beyond ProgressionNo drug interventionstreatment2terminated
NCT03395899
Pre-operative Immunotherapy Combination Strategies in Breast CancerNo drug interventionsother2completed
NCT01100489
Breast-Conserving Surgery Followed by Radiation Therapy With MRI-Detected Stage I or Stage II Breast CancerNo drug interventionstreatment2withdrawn
NCT03886389
Breast Cancer Diet Intervention StudyNo drug interventionsbasic_scienceNot Availablecompleted
NCT04038489
COX Inhibition and Biomarkers During Neoadjuvant Chemoendocrine Therapy for ER+, HER2- Stage I-III Breast Cancertreatment2withdrawn
NCT00194792
Hormone Therapy and Combination Chemotherapy Before and After Surgery in Treating Patients With Stage I-IIIA Breast Cancertreatment2terminated
NCT01194440
Zoledronic Acid in Aromatase Inhibitor Induced Musculoskeletal SymptomsNo drug interventionssupportive_care2completed
NCT03285568
Patterns of Prescribing and Monitoring of PalbociclibNo drug interventionsNot AvailableNot Availablecompleted
NCT03719495
Evaluation of Endocrine Therapy Effects of Host Immunity in Early Stage Breast CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT05076695
Neoadjuvant With Trastuzumab, Pyrotinib Plus Palbociclib and Fulvestrant in HER2-positive, ER-positive Breast CancerNo drug interventionstreatment2recruiting
NCT06062498
Elacestrant vs Elacestrant Plus a CDK4/6 Inhibitor in Patients With ERpositive/HER2-negative Advanced or Metastatic Breast Cancertreatment2not_yet_recruiting
NCT04504916
A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)treatment2terminated
NCT06525766
Adaptive Therapy With Capecitabine for the Treatment of Metastatic Estrogen Receptor Positive, HER2 Negative Breast Cancertreatment2not_yet_recruiting
NCT05607004
(Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast CancerNo drug interventionstreatment2recruiting
NCT06006910
Electronic Medical Record-Based Nudge to Reduce SLNBNo drug interventionsNot AvailableNot Availablecompleted
NCT06343987
The FEMA Study: Feasibility of Exercise in Patients With Metastatic Breast Cancer and AdiposityNo drug interventionstreatmentNot Availablerecruiting
NCT06150898
Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt)No drug interventionsother2not_yet_recruiting
NCT01992952
Fulvestrant +/- Akt Inhibition in Advanced Aromatase Inhibitor Resistant Breast Cancertreatment1 / 2unknown_status
NCT01765049
Breast Density Change Predicting Response to Adjuvant Aromatase InhibitorNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02216786
A Randomized Study of AZD2014 in Combination With Fulvestrant in Metastatic or Advanced Breast Cancertreatment2unknown_status
NCT02988986
TAK-228 Plus Tamoxifen in Patients With ER-Positive, HER2-negative Breast Cancertreatment2completed
NCT03250676
Trial of H3B-6545, in Women With Locally Advanced or Metastatic Estrogen Receptor-positive, HER2 Negative Breast CancerNo drug interventionstreatment1 / 2completed
NCT02238808
A Study to See Whether Estrogen Can Slow the Growth of Some ER Positive Breast CancersNo drug interventionstreatment2active_not_recruiting
NCT01984138
REVIVE: Replens Versus Intra-Vaginal Estrogen for the Treatment of Vaginal Dryness on Aromatase Inhibitor TherapyNo drug interventionstreatment2recruiting
NCT00066690
Suppression of Ovarian Function With Either Tamoxifen or Exemestane Compared With Tamoxifen Alone in Treating Premenopausal Women With Hormone-Responsive Breast Cancertreatment3active_not_recruiting
NCT02820961
Drug-Drug Interaction Study of Entinostat and Exemestane in Postmenopausal Women With ER+ Breast CancerNo drug interventionstreatment1completed
NCT02947685
Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast CancerNo drug interventionstreatment3active_not_recruiting
NCT04727632
[18F]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE TrialNo drug interventionsdiagnostic0recruiting
NCT02000375
A Phase II Study Evaluating the Role of Androgen Receptors as Targets for Therapy of Pre-treated Post-menopausal Patients With ER/PgR-negative/AR-positive or ER and/or PgRpositive/ AR-positive Metastatic Breast Cancer (ARTT)No drug interventionstreatment2terminated
NCT01219699
A Study of BYL719 in Adult Patients With Advanced Solid Malignancies, Whose Tumors Have an Alteration of the PIK3CA GeneNo drug interventionstreatment1completed
NCT02409316
[18F]FES PET/CT in Endocrine Refractory Breast CancerNo drug interventionsdiagnostic2active_not_recruiting
NCT02668666
Palbociclib in Combination With Tamoxifen as First Line Therapy for Metastatic Hormone Receptor Positive Breast CancerNo drug interventionstreatment2completed
NCT02414776
Hydroxychloroquine in Metastatic Estrogen Receptor-Positive Breast Cancer Progressing on Hormonal TherapyNo drug interventionstreatment1terminated
NCT02823262
A Breast Cancer Treatment Decision Aid for Women Aged 70 and OlderNo drug interventionshealth_services_researchNot Availableterminated
NCT01996046
FDG PET/CT in Breast Cancer Bone MetsNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04360941
PAveMenT: Palbociclib and Avelumab in Metastatic AR+ Triple Negative Breast Cancerother1recruiting
NCT05423730
Alcohol and Breast Cancer (ABC) TrialNo drug interventionsbasic_science0completed
NCT04985266
A Trial of Early Detection of Molecular Relapse With Circulating Tumour DNA Tracking and Treatment With Palbociclib Plus Fulvestrant Versus Standard Endocrine Therapy in Patients With ER Positive HER2 Negative Breast Cancertreatment2recruiting
NCT01202591
Safety and Efficacy of AZD4547 in Combination With Fulvestrant vs. Fulvestrant Alone in ER+ Breast Cancer Patientstreatment1 / 2completed
NCT06407401
Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Patients With Early Breast CancerNo drug interventionssupportive_care3not_yet_recruiting
NCT05490472
JAB-2485 Activity in Adult Patients With Advanced Solid TumorsNo drug interventionstreatment1 / 2recruiting
NCT04551495
Neoadjuvant Study of Targeting ROS1 in Combination With Endocrine Therapy in Invasive Lobular Carcinoma of the Breast (ROSALINE)No drug interventionstreatment2active_not_recruiting
NCT00828854
Study of the Effect of the Addition of SNDX-275 (Entinostat) to Continued Aromatase Inhibitor (AI) Therapy in Postmenopausal Women With ER+ Breast Cancer Whose Disease is ProgressingNo drug interventionstreatment2completed
NCT03983954
Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid TumorsNo drug interventionstreatment1active_not_recruiting
NCT04312347
Tamoxifen Dose Adjustment on Indonesian Female ER+ Breast Cancer Patients Based on CYP2D6 Genotype and Endoxifen LevelsNo drug interventionstreatmentNot Availablecompleted
NCT06395519
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid MalignanciesNo drug interventionstreatment1recruiting
NCT02580448
CYP17 Lyase and Androgen Receptor Inhibitor Treatment With Seviteronel Trial (INO-VT-464-006; NCT02580448)No drug interventionstreatment1 / 2completed
NCT06064812
A Phase I Clinical Trial of FWD1802 in Patients With ER+/HER2- BC.No drug interventionstreatment1recruiting
NCT05525481
Tamoxifen Prediction Study in Patients With ER+ Breast CancerNo drug interventionstreatment4recruiting
NCT04824014
4FMFES-PET Imaging of ER+ Advanced Breast CancersNo drug interventionsdiagnostic2recruiting
NCT04920708
Fulvestrant, Ipatasertib and CDK4/6 Inhibition in Metastatic ER+/HER2- Breast Cancer Patients Without ctDNA SuppressionNo drug interventionstreatment2recruiting
NCT05534438
A Study on Adding Precisely Targeted Radiation Therapy (Stereotactic Body Radiation Therapy) to the Usual Treatment Approach (Drug Therapy) in People With Breast CancerNo drug interventionstreatment2recruiting
NCT05101564
Umbrella Trial Testing Integrative Subtype Targeted Therapeutics in Estrogen Receptor Positive, HER2-Negative Breast CancerNo drug interventionstreatment2active_not_recruiting
NCT01361945
AUY922 With Lapatinib and Letrozole for ER+ HER2+ Advanced Breast Cancertreatment1 / 2withdrawn
NCT06176261
DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEstreatment2recruiting
NCT04568616
Phase II Study of Neoadjuvant ArOMatase Inhibitor Therapy for ER+ Breast Cancer (NAOMI)treatment2recruiting
NCT04660435
To Identify Primary Resistance to CDK4/6 Inhibitors in Breast CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT05868226
PRE-I-SPY Phase I/Ib Oncology Platform Programtreatment1recruiting
NCT04504331
Study of Infigratinib in Combination With Tamoxifen in Hormone Receptor Positive, HER2 Negative, FGFR Altered Advanced Breast Cancertreatment1terminated
NCT04886531
Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancerstreatment2recruiting
NCT05720260
Immunotherapy, Hormone Therapy, and AKT Inhibitor for Premenopausal ER Positive MBCtreatment2recruiting
NCT06016738
OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast CancerNo drug interventionstreatment3recruiting
NCT04901299
Fulvestrant + Neratinib In Breast CancerNo drug interventionstreatment2withdrawn
NCT04276272
D4 Choline Breast PET/CTNo drug interventionsNot AvailableNot Availablecompleted
NCT05396612
Role of the Immune Environment in Response to Therapy in Breast CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT05512364
Elacestrant for Treating ER+/HER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA)No drug interventionstreatment3recruiting
NCT06525675
Study to Evaluate the Extended Overall Survival (OS) Data From PARSIFAL Study (The PARSIFAL-LONG Study)Not AvailableNot Availableactive_not_recruiting
NCT05163106
Neoadjuvant Treatment of Locally-advanced Breast Cancer Patients With Ribociclib and Letrozoletreatment2completed
NCT05305924
Fulvestrant+Abemaciclib With Run-In of Fulvestrant in Er-Positive, Her2-Negative Metastatic Breast Cancertreatment2recruiting
NCT06382948
Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.treatment3not_yet_recruiting
NCT04738292
Onapristone and Fulvestrant for ER+ HER2- Metastatic Breast Cancer After Endocrine Therapy and CDK4/6 Inhibitors (The SMILE Study)No drug interventionstreatment2terminated
NCT05826964
Levels of Circulating Tumor DNA as a Predictive Marker for Early Switch in Treatment for Patients With Metastatic (Stage IV) Breast CancerNo drug interventionstreatment2recruiting
NCT00965939
An Observational Study to Assess Response to Tamoxifen in Breast Cancer PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT02345772
Neoadjuvant Hormonal Therapy Combined With ChemoimmunotherapyNo drug interventionstreatment1 / 2terminated
NCT04236310
A Study of Neoadjuvant SHR6390 in Combination With Anastrozole, Pyrotinib, and Trastuzumab in Patients With ER+/HER2+ Breast Cancer.No drug interventionstreatment2unknown_status