Beta-Thalassemia Major (DBCOND0071225)

Identifiers

Synonyms
Beta Thalassemia Major Anemia / Anemia, Cooley's / Beta Thalassemia Major / Β-thalassemia Major / Β Thalassemia Major / Cooley's anemia / Beta thalassemia / Mediterranean anemia / Mediterranean anaemia / Thalassemia major / Cooley's anaemia / Thalassaemia major / Thalassemia major (disorder) / Homozygous beta thalassemia (disorder) / Thalassemia beta / Beta thalassaemia / Beta thalassemia (disorder) / Thalassaemia beta / Beta-thalassaemia / Beta-Thalassemia

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02984475
The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia Majortreatment4unknown_status
NCT04962984
Thrombin Generation in Beta-thalassemia MajorNo drug interventionsbasic_scienceNot Availableunknown_status
NCT05693909
A Trial Testing SP-420 in Subjects With Transfusion-dependent β-thalassemiatreatment2recruiting
NCT03948737
The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia MajortreatmentNot Availablecompleted
NCT03591575
Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Childrentreatment4completed
NCT00000623
Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)Not AvailableNot Availablecompleted
NCT04092205
Phase 2a Pilot Study of NBMI Treatment in Patients With Beta Thalassemia Major, Requiring Iron Chelationtreatment2completed
NCT00658385
Assess the Feasibility and Safety of Granulocyte Colony Stimulating Factor (GCSF) Mobilization of CD34+ Hematopoietic Progenitor Cells in Patients With Betathalassemia MajorNo drug interventionstreatmentNot Availablecompleted
NCT03947632
Anthropometric Measurements in Children Having Transfusion-dependent Beta ThalassemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT02744560
Effect of Spirulina on Liver Iron Concentration in Beta Thalassemic Children With Hepatitis CNo drug interventionssupportive_careNot Availablecompleted
NCT06466304
Inspiratory Muscle Training in Children With Beta ThalasemiaNo drug interventionstreatmentNot Availablerecruiting
NCT03276455
Gene Therapy for Beta-Thalassemia Major Using Autologous Hematopoietic Stem Cell Genetically ModifiedNo drug interventionstreatment1 / 2unknown_status
NCT03101423
Monitoring of Chimerism After Transplantation in Patients With β Thalassemia Major and the Treatment Strategies for the Reduction of ChimerismtreatmentNot Availableunknown_status
NCT02173951
An Algorithm to Start Iron Chelation in Minimally Transfused Young Beta-thalassemia Major Patientstreatment2 / 3unknown_status
NCT02744547
Effect of Spirulina on Serum Hyaluronic Acid in Beta Thalassemic Children With Hepatitis CNo drug interventionssupportive_careNot Availablecompleted
NCT02744105
Effect of Spirulina on Liver Fibrosis by Transient Elastography in Beta Thalassemic Children With Hepatitis CNo drug interventionssupportive_careNot Availablecompleted
NCT02674607
the Potential Immunomodulatory Effects of Spirulina on Thalassemic ChildrenNo drug interventionspreventionNot Availablecompleted
NCT01571635
Study to Determine the Safety and Tolerability of Sotatercept (ACE-011) in Adults With Beta( β)- Thalassemia.treatment2terminated
NCT04353986
PK of SOF/LED in HCV - Infected Adolescents With Haematological Disorderstreatment3recruiting
NCT02671695
Effect of Spirulina Compared to Amlodipine on Cardiac Iron Overload in Children With Beta ThalassemiatreatmentNot Availablecompleted
NCT04776850
Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathiestreatment0withdrawn
NCT06596642
A Real-World Study of β-Thalassemia Major Treatment With Luspatercept in TaiwanNot AvailableNot Availablerecruiting
NCT04205435
β-globin Restored Autologous HSC in β-thalassemia Major PatientsNo drug interventionstreatment1 / 2terminated
NCT01745120
A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major ParticipantsNo drug interventionstreatment1 / 2completed
NCT05776173
Safety and Efficacy of Gene Modified Autologous Hematopoietic Stem Cells to Treat Transfusion-dependent β-thalassemiaNo drug interventionstreatmentNot Availablerecruiting
NCT01724138
An Open Label Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Efficacy of Deferasirox Administered to Chinese Patients With β-thalassemia Major Aged From 2 to Less Than 6 Years Oldtreatment4withdrawn
NCT00390858
A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload.treatment2completed
NCT01846923
B Memory Cell Response to Vaccination With the 13-valent Pneumococcal Conjugate Vaccine in Asplenic IndividualsNo drug interventionsprevention4unknown_status
NCT04592458
Safety and Efficacy Evaluation of β-globin Restored Autologous Hematopoietic Stem Cells in β-thalassemia Major PatientsNo drug interventionstreatment1not_yet_recruiting
NCT04211480
Safety and Efficacy Evaluation of γ-globin Reactivated Autologous Hematopoietic Stem CellsNo drug interventionstreatmentNot Availablecompleted
NCT02342145
Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Majorprevention4unknown_status
NCT06291961
A Safety and Efficacy Study Evaluating CS-101 in Subjects With β-Thalassemia MajorNo drug interventionstreatment1recruiting
NCT00999349
Therapeutic Effects of Silymarin in Patients With B-thalassemia Majortreatment2 / 3unknown_status
NCT02151526
A Study Evaluating the Safety and Efficacy of LentiGlobin BB305 Drug Product in β-Thalassemia Major (Also Referred to as Transfusion-dependent β-Thalassemia [TDT]) and Sickle Cell Diseasetreatment1 / 2completed
NCT03653338
T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemiastreatment1 / 2recruiting
NCT01511848
Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overloadtreatment2 / 3unknown_status
NCT03040765
Denosumab Versus Zoledronic Acid in Thalassemia-Induced Osteoporosistreatment3terminated
NCT02435901
HSCT For Patients With High Risk Hemoglobinopathies Using Reduced Intensitytreatment1 / 2completed
NCT00171301
Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration)treatment4completed
NCT02198508
Clinical Trial of Deferasirox Combination Treatment With Deferiprone In Thalassaemia PatientstreatmentNot Availablecompleted