Pyrimidinones
- Name
- Pyrimidinones
- Accession Number
- DBCAT000729
- Description
Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.
- Drugs
Drug Drug Description Butabarbital A barbiturate drug used as a sedative and hypnotic. Butalbital A barbiturate drug used for symptomatic treatment of tension-type headache in various combinations with acetaminophen, aspirin, caffeine, and codeine. Talbutal For use as a sedative and hypnotic. Pentobarbital A barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures. Cidofovir An antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. Secobarbital A barbiturate used for the short-term treatment of insomnia. Metharbital Metharbital is used for the treatment of epilepsy. Methohexital An anesthetic used to induce deep sedation. Fluorouracil A pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. Propylthiouracil A thiourea antithyroid agent used to treat hyperthyroidism. Thiopental A barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Uracil mustard Used for its antineoplastic properties. Primidone An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures. Methylphenobarbital For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. Flucytosine An antifungal indicated only to treat severe infections throughout the body caused by susceptible strains of Candida or Cryptococcus. Capecitabine A nucleoside metabolic inhibitor indicated to treat colon, colorectal and breast cancer. Thiamylal Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state. Phenobarbital A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. Amobarbital A barbiturate derivative used for the induction of sedation during procedures, short-term management of insomnia, and acute management of refractory tonic-clonic seizures. Aprobarbital Aprobarbital is a barbiturate derivative synthesized in the 1920s by Ernst Preiswerk. It was determined that the substance was capable of demonstrating sedative, hypnotic, and anticonvulsant effects. A primary treatment... Butobarbital For the treatment of insomnia. Heptabarbital Used mainly for sedation and hypnosis. Hexobarbital For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful... Barbital A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice... Lopinavir An HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. Orotic acid Not Available Uracil Not Available Thymine Not Available Eniluracil For the treatment of cancer in combination with 5-fluorouracil. 5-Iodouracil Not Available 5,6-Diaminouracil Not Available 3-Methylcytosine Not Available Willardiine Willardiine is a compound isolated from seeds of Acacia willariana. Sparsomycin An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems. [PubChem] 1-Methylcytosine Not Available Troxacitabine Investigated for use/treatment in leukemia (myeloid). Alogliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus. Sapacitabine Investigated for use/treatment in solid tumors, cutaneous t-cell lymphoma, myelodysplastic syndrome, and leukemia (lymphoid). Barbexaclone Created for the treatment for epilepsy, with the intent of creating an antiepileptic with less sedative properties than phenobarbital. Carmofur Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy. Dasabuvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. Tegafur An antineoplastic agent used in combination with other anticancer medications to treat advanced gastric and colorectal cancers. Daprodustat Daprodustat has been used in trials studying the other, treatment, and basic science of Anaemia, Wound Healing, Tendon Injuries, Surgical Procedures, and Vascular Disease, Peripheral. CE-224535 CE-224535 has been used in trials studying the treatment of Osteoarthritis. Brincidofovir Brincidofovir is under investigation for the prevention of Outcomes, Survival Rates, and Cytomegalovirus Disease. Brincidofovir has been investigated for the prevention and treatment of CMV, Adenovirus, BK Virus (BKV), Adenoviruses... Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Zoliflodacin Zoliflodacin has been used in trials studying the basic science and treatment of Gonorrhoea. MGL-3196 MGL-3196 has been used in trials studying the treatment of Non-alcoholic steatohepatitis and Heterozygous Familial Hypercholesterolemia. Enibomal Not Annotated Proxibarbal Proxibarbal is a derivative of barbiturates, which has been used to treat migraines. Proxibarbal was approved in France but was withdrawn from the market due to the risk of inducing... Febarbamate Not Annotated Allobarbital Not Annotated Methylthiouracil Not Annotated Cyclobarbital Not Annotated Vinylbital Not Annotated Magnesium orotate Magnesium orotate is a magnesium salt of orotic acid and is poorly soluble in water. It is a source of magnesium and is used as a mineral supplement to treat... Benzylthiouracil Not Annotated Emivirine Emivirine has been used in trials studying the treatment of HIV Infections. Trelagliptin Trelagliptin is under investigation in clinical trial NCT03555591 (Specified Drug-Use Survey of Trelagliptin Tablets "Survey on Long-term Use in Patients With Type 2 Diabetes Mellitus"). Tipiracil A thymidine phosphorylase inhibitor used as an adjunct treatment of adult patients with certain types of gastric or colorectal malignancies. Mavacamten Mavacamten is under investigation in clinical trial NCT03442764 (A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)). ABT-072 ABT-072 is under investigation in clinical trial NCT00890318 (A Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetic Profiles of Multiple Doses of ABT-072 Used to Treat... Bropirimine Not Available 5-Benzylacyclouridine Not Available Dihydrouracil Not Available 5-Aminouracil Not Available - Drugs & Drug Targets