Antiplatyhelmintic Agents

Antiplatyhelmintic Agents
Accession Number

Agents used to treat cestode, trematode, or other flatworm infestations in man or animals.

DrugDrug Description
AlbendazoleA benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections.
OxamniquineFor treatment of Schistosomiasis caused by Schistosoma mansoni
QuinacrineFor the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions.
BithionolBithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the...
LucanthoneIntended for use as a radiation sensitizer in the treatment of brain cancer.
NiclosamideAn anthelmintic indicated in the treatment of beef, pork, fish, and dwarf tapeworm infections in adults and children.
ClorsulonNot Annotated
DichlorophenDichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from...
OltiprazOltipraz has been used in trials studying the treatment and prevention of Lung Cancer, Liver Fibrosis, Liver Cirrhosis, and Non-alcoholic Fatty Liver Disease.
NiridazoleNot Annotated
ArtemotilArtemotil, also known as β-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria...
Albendazole oxideNot Annotated
HycanthonePotentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used.
ArtesunateArtesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
TriclabendazoleAn anthelmintic drug used to treat fascioliasis.
Antimony potassium tartrateAntimony potassium tartrate is a schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects.
Sodium stibogluconateFor the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment...
ChloroxylenolAn antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner.
Drugs & Drug Targets
AlbendazoleTubulin alpha-1A chaintarget
AlbendazoleTubulin beta-4B chaintarget
AlbendazoleCytochrome P450 3A4enzyme
AlbendazoleFumarate reductase flavoprotein subunittarget
AlbendazoleCytochrome P450 1A1enzyme
AlbendazoleCytochrome P450 1A2enzyme
AlbendazoleTubulin beta-2 chaintarget
AlbendazoleCytochrome P450 2C19enzyme
AlbendazoleP-glycoprotein 1transporter
OxamniquineCytochrome P450 2D6enzyme
Quinacrine85/88 kDa calcium-independent phospholipase A2target
QuinacrineCytosolic phospholipase A2target
QuinacrineInactive phospholipase C-like protein 1target
QuinacrineHistamine N-methyltransferaseenzyme
QuinacrineSolute carrier family 22 member 2transporter
QuinacrineP-glycoprotein 1transporter
QuinacrineCytochrome P450 3A4enzyme
QuinacrineCytochrome P450 3A5enzyme
LucanthoneDNA topoisomerase 2-alphatarget
LucanthoneDNA-(apurinic or apyrimidinic site) lyasetarget
LucanthoneDNA topoisomerase 1target
NiclosamideCytochrome P450 2C9enzyme
NiclosamideCytochrome P450 1A2enzyme
HycanthoneP-glycoprotein 1target
HycanthoneP-glycoprotein 1transporter
ArtesunateMalaria protein EXP-1target
ArtesunateCytochrome P450 2A6enzyme
ArtesunateUDP-glucuronosyltransferase 2B7enzyme
ArtesunateUDP-glucuronosyltransferase 1-9enzyme
ArtesunateATP-binding cassette sub-family G member 2transporter
ArtesunateP-glycoprotein 1transporter
ArtesunateSolute carrier organic anion transporter family member 1B1transporter
ArtesunateSolute carrier family 22 member 8transporter
ArtesunateSerum albumincarrier
TriclabendazoleCytochrome P450 1A2enzyme
TriclabendazoleCytochrome P450 2C9enzyme
TriclabendazoleExcretory Secretory (ES) proteinstarget
TriclabendazoleCytochrome P450 3A4enzyme
TriclabendazoleCytochrome P450 1A1enzyme
TriclabendazoleCytochrome P450 1B1enzyme
TriclabendazoleCytochrome P450 2C19enzyme
TriclabendazoleCytochrome P450 2D6enzyme
TriclabendazoleCytochrome P450 2A6enzyme
TriclabendazoleCytochrome P450 2C8enzyme
TriclabendazoleCytochrome P450 2B6enzyme
Sodium stibogluconateDNA topoisomerase 1target