NCT03530046
High Strong Ion Difference Fluid vs Hartmann's Solution on Acid-Base Status in Sepsis No drug interventions treatment Not Available completed NCT04931485
Protocolised Early De-Resuscitation in Septic Shock (REDUCE) No drug interventions other Not Available recruiting NCT05586282
Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure No drug interventions Not Available Not Available recruiting NCT05990491
Pituitary Function After Recovery From Septic Shock Among ICU Survivors No drug interventions Not Available Not Available recruiting NCT06122909
The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capillary Refill Time In Adult Patients With Septic Shock No drug interventions treatment 3 recruiting NCT06464510
Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis treatment 3 recruiting NCT06634069
Study SOLACE SEPSIS treatment 2 not_yet_recruiting NCT06570187
The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients supportive_care 4 recruiting NCT03158948
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 3 Doses of MOTREM (Nangibotide) in Patients With Septic Shock treatment 2 completed NCT03401398
Stress Hydrocortisone In Pediatric Septic Shock treatment 3 recruiting NCT04513288
ICITRU : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for Sepsis or Septic Shock No drug interventions treatment Not Available recruiting NCT06568744
Fluid Intolerance Signals as Safety Limits to Prevent Fluid-induced Harm During Septic Shock Resuscitation No drug interventions treatment Not Available recruiting NCT06623825
Smart Glasses in Emergency Medicine From the Hangzhou Asian Games No drug interventions Not Available Not Available completed NCT04827407
Lipopolysaccharide Adsorption At Septic Shock No drug interventions treatment Not Available completed NCT04963920
A RCT to Assess the Performance of CytoSorb for Shock Reversal in Patients With Vasoplegic Septic Shock No drug interventions treatment Not Available recruiting NCT05148286
Albumin and Crystalloid Administration in Septic Shock treatment 4 recruiting NCT05975671
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis No drug interventions other Not Available recruiting NCT06545838
Renin Levels as Prognostic Indicators of Septic Shock Severity and Outcome No drug interventions Not Available Not Available not_yet_recruiting NCT06592547
Intravenous Metoprolol in Septic Shock treatment 2 active_not_recruiting NCT06602245
Clearance of Antibacterial Agents During Hemoperfusion in Patients With Sepsis No drug interventions Not Available Not Available not_yet_recruiting NCT04550143
Muscle Ultrasound Study in Shock Patients No drug interventions Not Available Not Available recruiting NCT02883803
Treatment of Severe Infections With Mesenchymal Stem Cells treatment Not Available unknown_status NCT04103203
Fast Assay for Pathogen Identification - Quasi-Experimental Intervention Study No drug interventions diagnostic Not Available completed NCT04134403
Steroids, Thiamine and Ascorbic Acid in Septic Shock No drug interventions treatment 3 unknown_status NCT06062303
Hemodynamic Phenotype-Based,Capillary Refill Time-Targeted Resuscitation In Early Septic Shock:ANDROMEDA-SHOCK-2 No drug interventions supportive_care Not Available recruiting NCT00005890
Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock diagnostic Not Available completed NCT00816790
Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock treatment 4 terminated NCT01310790
Strategy of Early Improvement of Tissue Oxygenation Decrease the Mortality of Severe Sepsis and Septic Shock No drug interventions treatment 4 completed NCT05633290
CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis. No drug interventions Not Available Not Available recruiting NCT06461390
The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock treatment 2 / 3 completed NCT05066464
Fluid Resuscitation for Suspected Sepsis in Paediatric Emergency Departments No drug interventions Not Available Not Available completed NCT01639664
COMPACT 2 - COMbining Plasma-filtration and Adsorption Clinical Trial 2 No drug interventions treatment Not Available terminated NCT03966664
Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients No drug interventions Not Available Not Available unknown_status NCT04742764
Extracorporal Cytokin Removal in Septic Shock: a Prospective, Randomized, Multicenter Clinical Trial No drug interventions treatment 3 suspended NCT02424721
Sepsis Assessment in Belgian Emergency Rooms No drug interventions Not Available Not Available terminated NCT01434121
Ascorbic Acid (Vitamin C) Infusion in Human Sepsis treatment 1 / 2 completed NCT01649921
The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis treatment 3 completed NCT04997421
Safety and Efficacy of HA380 Hemoadsorption in Patients With Septic Shock No drug interventions treatment Not Available recruiting NCT05444621
Carotid Ultrasounds Measurements in Septic Shock No drug interventions Not Available Not Available not_yet_recruiting NCT04366921
European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO No drug interventions Not Available Not Available unknown_status NCT03113721
Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis No drug interventions Not Available Not Available unknown_status NCT02079402
Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care No drug interventions treatment 4 completed NCT01836302
Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study) No drug interventions Not Available Not Available completed NCT04970602
The Effect of Early Use of Methylene Blue on Hemodynamics in Septic Shock treatment Not Available unknown_status NCT05957302
Hemodynamic Effects of Bolus of Ketamine Versus Fentanyl in Patients With Septic Shock supportive_care Not Available completed NCT05225402
Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU Not Available Not Available unknown_status NCT05900284
Safety and Feasibility of Metformin for Sepsis Induced AKI treatment 2 enrolling_by_invitation NCT03844984
Lidocaine-Ketamine Versus Ketamine for Induction of Anesthesia in Septic Shock Patients treatment 3 completed NCT01823484
Effects of AN69 ST Hemofilter on Coagulation During Continuous Renal Replacement Therapy in Critically Ill No drug interventions treatment Not Available unknown_status NCT05950984
Medical Device (MD) Derived Pharmacokinetic (PK) Parameters for Vancomycin (MD-PK) No drug interventions Not Available Not Available recruiting NCT05602584
Effect of Immunophenotype on Prognosis of Sepsis No drug interventions Not Available Not Available enrolling_by_invitation NCT05122884
Milrinone Versus Placebo in Patients With Septic Shock treatment 2 recruiting NCT06287684
Molecular Endotype-Specific Dynamics of Lung Endothelial Barrier Integrity in Sepsis No drug interventions Not Available Not Available recruiting NCT03734484
Gram Type Infection-Specific Sepsis Identification Using Machine Learning No drug interventions diagnostic 2 withdrawn NCT03472079
TIMP2*IGFBP7 and Transient AKI No drug interventions Not Available Not Available recruiting NCT03426943
Endotoxins and Cytokines Removal During Continuous Hemofiltration With oXiris™ No drug interventions other Not Available completed NCT05080543
Microcirculation Recruitment Using Albumin 20% and Terlipressin in Septic Patients treatment 1 unknown_status NCT02820987
PK/PD of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock treatment 3 unknown_status NCT01747187
Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome No drug interventions Not Available Not Available unknown_status NCT02068287
Esmolol Effects on Heart and Inflammation in Septic Shock treatment 2 unknown_status NCT00842933
Adrenal Insufficiency in Septic Shock treatment 4 terminated NCT03649633
Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock treatment 1 / 2 recruiting NCT04567433
Days Alive and Out of Hospital for Patients With Sepsis Not Available Not Available completed NCT06013033
DDX17 Orchestrate Septic Vascular Endothelial Pyroptosis by Controlling Gasdermin D Pore Formation No drug interventions Not Available Not Available not_yet_recruiting NCT02237833
Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study No drug interventions Not Available Not Available terminated NCT03015454
An Algorithm Driven Sepsis Prediction Biomarker No drug interventions screening Not Available completed NCT02647554
Ulinastatin Treatment in Adult Patients With Sepsis and Septic Shock in China treatment 4 completed NCT05001854
Hemodynamics Effects of Fludrocortisone on the Pressor Response to Noradrenaline Septic Shock Patients treatment 2 / 3 suspended NCT03782454
Quantification of Bacterial DNA in Sepsis No drug interventions Not Available Not Available unknown_status NCT05443854
Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill Neutropenic Patients With Sepsis: (Combination-Lock01) No drug interventions treatment 3 unknown_status NCT05159154
Myocardial Work in Septic Shock Patients No drug interventions Not Available Not Available unknown_status NCT02963454
Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock screening Not Available unknown_status NCT03572751
Suitability of Unobtrusive Bed Monitoring and Wrist-worn Heart Rate Monitor for Patient Monitoring No drug interventions Not Available Not Available completed NCT01539551
Investigation of the Role of Brain Natriuretic Peptide and Lactate in Early Goal-directed Therapy for Patients With Severe Sepsis and Septic Shock No drug interventions Not Available Not Available unknown_status NCT02565251
Volemic Resuscitation in Sepsis and Septic Shock No drug interventions treatment Not Available unknown_status NCT01611753
Red Blood Cell Transfusion Improves Perfusion Parameters in Septic Shock Patients With Hypoperfusion No drug interventions Not Available Not Available completed NCT04610853
Rotational Thromboelastometry Versus DIC Score in Sepsis No drug interventions Not Available Not Available recruiting NCT03895853
Early Metabolic Resuscitation for Septic Shock No drug interventions supportive_care 2 terminated NCT03706053
Midodrine Use in Septic Shock treatment 3 terminated NCT01271153
Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients treatment Not Available completed NCT01193777
L-Carnitine Administration in Early Sepsis treatment 1 terminated NCT06446947
Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis No drug interventions Not Available Not Available not_yet_recruiting NCT01787045
Early Physical Therapy in Patients With Sepsis No drug interventions basic_science Not Available terminated NCT03092245
Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock (SHOCK) Trial treatment 2 completed NCT01473498
Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock No drug interventions treatment Not Available completed NCT04089098
VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility No drug interventions Not Available Not Available completed NCT01877798
Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Septic Shock Therapy No drug interventions treatment Not Available unknown_status NCT01231698
Heart Rate Control With Esmolol in Septic Shock treatment 2 completed NCT01867905
Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock No drug interventions Not Available Not Available completed NCT04778605
Modulation of Endothelial Dysfonction Using Vitamin C in Septic Shock Patients No drug interventions Not Available Not Available unknown_status NCT02716597
Effect of Albumin Administration on Vasopressor Duration in Resolving Septic Shock supportive_care 1 terminated NCT02842983
Pilot Study: Echocardiographic and Hemodynamic Effects of Esmolol in Septic Shock Patients treatment 2 / 3 unknown_status NCT05283083
Decatecholaminisation of Septic Shock With Dexmedetomidine and In-hospital Mortality treatment 2 completed NCT01945983
Early Use of Norepinephrine in Septic Shock Resuscitation treatment Not Available completed NCT05136183
CLinical Efficacy of Hemoperfusion With a Cytokine Adsorber in Norepinephrine-Resistant SEptic Shock No drug interventions treatment Not Available unknown_status NCT03866083
Safety and Efficacy of Extracorporeal Cytokine Hemoadsorption in Septic Shock in Critically Ill Cirrhotics No drug interventions treatment Not Available unknown_status NCT04409561
Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population No drug interventions Not Available Not Available completed NCT05355961
Effect of Norepinephrine Administration on Ventricular Systolic Function in Septic Shock No drug interventions Not Available Not Available completed NCT04425161
Ratio of ''Central Venous-to-Arterial Co2 Gap'' to ''Arterial-to-Central Venous O2 Content Gap'' in Septic Shock No drug interventions Not Available Not Available unknown_status NCT05190861
Evaluation of Droplet Digital PCR Rapid Detection Method and Precise Diagnosis and Treatment for Suspected Sepsis No drug interventions diagnostic Not Available unknown_status NCT00241228
Haemofiltration Study : IVOIRE (hIgh VOlume in Intensive Care) No drug interventions treatment Not Available completed NCT00273728
BaSES Trial: Basel Starch Evaluation in Sepsis treatment 4 completed NCT03540628
Thiamine, Vitamin C and Hydrocortisone in the Treatment of Septic Shock No drug interventions supportive_care Not Available unknown_status NCT01972828
Early Haemodynamic Optimization Using Preload Dependence During Septic Shock = EHOSS-1 treatment Not Available completed NCT02533011
Evaluation of the Heparin Binding Protein Levels in Sepsis No drug interventions Not Available Not Available completed NCT02050893
The Effect of Midazolam on Fluid Responsiveness in Septic Patients treatment 1 / 2 completed NCT04910893
Cytokine Adsorption in Severe, Refractory Septic Shock No drug interventions treatment Not Available completed NCT03235193
Predictive algoRithm for EValuation and Intervention in SEpsis No drug interventions diagnostic Not Available completed NCT04446871
Methylene Blue in Early Septic Shock treatment 2 / 3 completed NCT05141071
Effect of Ivabradine on Microcirculation and Cardiac Output in Septic Shock Patients treatment 2 completed NCT05441878
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension treatment 4 unknown_status NCT01149278
Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock No drug interventions treatment Not Available completed NCT00148278
Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock treatment 2 / 3 completed NCT04153578
Time to Lose the Weight? Comparison of Weight-based and Non-weight-based Vasopressors for Septic Shock No drug interventions Not Available Not Available completed NCT01797978
Methylene Blue in Severe Sepsis and Septic Shock treatment 3 unknown_status NCT01862588
Renal Resistive Index and Cardiac Output Changes During Resuscitation Predict the Occurrence of Acute Kidney Injury in Septic Shock Patients No drug interventions Not Available Not Available unknown_status NCT02885688
Early Metabolic Support as a Potential Solution to Multi-Organ Dysfunction Syndrome (MODS) During Severe Sepsis No drug interventions supportive_care 2 withdrawn NCT02188888
Echocardiographic and Arterial Pressure Waveform Changes After Reducing Heart Rate With Esmolol in Septic Shock Patients Not Available Not Available completed NCT00527007
External Cooling in Septic Shock Patients No drug interventions treatment Not Available completed NCT03380507
Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock treatment 2 / 3 terminated NCT06426407
Vasopressin Hemodynamic Response as a Septic Shock Subphenotype Indicator Not Available Not Available not_yet_recruiting NCT01448109
ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock treatment 4 completed NCT01150409
Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock treatment 4 terminated NCT04434209
A Study Looking at the Use of Biomarkers to Provide Early Indication of Acute Kidney Injury in Patients With Sepsis (Limiting AKI Progression In Sepsis) No drug interventions diagnostic 4 terminated NCT02180009
Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis No drug interventions Not Available Not Available completed NCT00625209
Activated Protein C and Corticosteroids for Human Septic Shock treatment 3 completed NCT01858909
Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock treatment 3 unknown_status NCT05066256
LV Diastolic Function vs IVC Diameter Variation as Predictor of Fluid Responsiveness in Shock No drug interventions diagnostic Not Available unknown_status NCT05011656
Blood Purification for the Treatment of Pathogen Associated Shock No drug interventions treatment Not Available recruiting NCT01775956
A Retrospective Review of a Comprehensive Cohort of Septic Shock: Assessment of Critical Determinants of Outcome No drug interventions Not Available Not Available unknown_status NCT05094856
Effects of Fluid Therapy on Peripheral TIssse Perfusion During Sepsis/Septic Shock No drug interventions Not Available Not Available completed NCT01062685
Near Infrared Spectroscopy (St02) No drug interventions Not Available Not Available completed NCT02301585
Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test No drug interventions treatment Not Available terminated NCT03869385
Albumin Replacement Therapy in Septic Shock treatment 3 unknown_status NCT06214715
Renal Resistive Index in Septic Shock Patients No drug interventions Not Available Not Available active_not_recruiting NCT00493415
The Effect of Nitroglycerine on Microcirculatory Abnormalities During Sepsis treatment 3 completed NCT01517815
Pharmacokinetic of Doripenem and Piperacillin/Tazobactam in More Than 120 kg Critically Ill Patients treatment Not Available completed NCT05725837
Effects of Paroxetine on Cardiovascular Function in Septic Patients treatment 2 recruiting NCT04182737
Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in Patients With Septic Shock. treatment 3 unknown_status NCT05961137
Orange Park Out-of-Hospital Quality Improvement Study for Improving CMS Sepsis Core Measures No drug interventions health_services_research Not Available completed NCT03399032
Pharmacokinetics of Caspofungin Not Available Not Available completed NCT04647552
Effects of Hydrocortison Treatment on Angiotensin II and Angiotensin II Receptors in Patients With Septic Shock Not Available Not Available completed NCT02204852
Co-administration of Iloprost and Eptifibatide in Septic Shock Patients treatment 2 completed NCT02609152
Effect of a Continuous Infusion of Esmolol on Stroke Volume in Patients With Hyperdynamic Vasoplegic Septic Shock treatment 3 withdrawn NCT06354452
Effect of Statin Therapy on Sepsis-related Mortality in Intensive Care Unit Patients No drug interventions Not Available Not Available completed NCT04282252
The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation No drug interventions treatment 4 unknown_status NCT05681052
Mottling Score and Central Venous Oxygen Saturation in Septic Shock Patients No drug interventions Not Available Not Available recruiting NCT02369900
Esmolol to Treat the Hemodynamic Effects of Septic Shock treatment 2 terminated NCT02962700
Effects of Continuous Haemofiltration vs Intermittent Haemodialysis on Microcirculatory Parameters in Septic Shock No drug interventions screening Not Available unknown_status NCT00449800
Pharmacokinetic of Ceftriaxone in Septic ICU Patients treatment 4 unknown_status NCT03494959
Pentaglobin in CRE and PA Neutropenic Infections treatment 2 recruiting NCT00793559
Terlipressin Administration in Septic Shock Refractory to Catecholamines supportive_care 2 unknown_status NCT01632059
Examination of ADMA Serum Level and DDAH II No drug interventions Not Available Not Available completed NCT03422159
Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis. treatment 2 completed NCT03085459
Effects of Nursing Staff on Empiric Antibiotic in Septic Shock No drug interventions Not Available Not Available completed NCT06118775
Evaluating Dynamic Arterial Elastance in Septic Shock Patients. No drug interventions treatment Not Available not_yet_recruiting NCT03369275
Cellular Immunotherapy for Septic Shock treatment 2 unknown_status NCT01411670
Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock. treatment 2 completed NCT05193370
Angiotensin II vs. Vasopressin in Septic Shock treatment 4 withdrawn NCT03405870
LIPIDS-P Trial Phase I/II treatment 1 / 2 recruiting NCT04716842
Evaluation of Plasma Angiotensin II and Angiotensin II Receptor Levels in Patients With Sepsis and Septic Shock: a Prospective Observational Study. No drug interventions Not Available Not Available unknown_status NCT01280942
Early Warning System for Clinical Deterioration on General Hospital Wards No drug interventions prevention Not Available completed NCT05310942
Non Invasive Evaluation of Fluid Responsiveness in Septic Patient No drug interventions Not Available Not Available unknown_status NCT03334006
Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis treatment 2 recruiting NCT01573806
Pharmacology of Exenatide in Pediatric Sepsis treatment 1 / 2 withdrawn NCT00800306
Effects of Levosimendan on Microcirculation in Septic Shock treatment 2 completed NCT03356249
Next-Generation Sequencing Diagnostics of Bacteremia in Sepsis No drug interventions Not Available Not Available completed NCT01000649
Effects of the V1a Agonist FE 202158 in Patients With Septic Shock treatment 2 completed NCT03621449
Velocity Time Integral vs PICCO for Evaluation of Passive Leg Raising in Septic Shock No drug interventions Not Available Not Available withdrawn NCT05731349
Impact of Early Sepsis Care Guided by the National Early Warning Score 2 in the Emergency Department No drug interventions treatment Not Available completed NCT03668236
The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial No drug interventions treatment 4 unknown_status NCT04796636
High-dose Intravenous Vitamin C in Patients With Septic Shock treatment 1 recruiting NCT05146336
CytOSorb TreatMent Of Critically Ill PatientS Registry No drug interventions Not Available Not Available recruiting NCT06368336
Health Related Quality of Life After Intensive Care for Sepsis, a National Cohort Study. No drug interventions Not Available Not Available completed NCT01648036
Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot treatment 2 completed NCT00398736
A Non-invasive Approach to the Assessment of Volume Status in Mechanically Ventilated Septic Patients. No drug interventions Not Available Not Available completed NCT05192213
Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock treatment 3 terminated NCT00835913
Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact No drug interventions Not Available Not Available completed NCT03528213
Utility of Sodium Lactate Infusion During Septic Shock treatment 2 / 3 unknown_status NCT01718613
Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients treatment 3 completed NCT02782013
Study of Progression of Community Acquired Pneumonia in the Hospital No drug interventions Not Available Not Available completed NCT05840718
Supplemental Thiamine in Septic Shock: A Before-after Study Not Available Not Available completed NCT05506319
Hypotension in the Weaning From Vasopressor Drugs No drug interventions prevention Not Available unknown_status NCT04921319
De-resuscitation Informed by Ultrasound for Patients With Sepsis No drug interventions treatment Not Available unknown_status NCT04576819
Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis No drug interventions Not Available Not Available completed NCT02876341
Effects of Chronic Antihypertensive Therapy on Clinical Outcomes in Septic Shock No drug interventions Not Available Not Available completed NCT05491941
Assessment for Implementation Methods in Sepsis No drug interventions treatment Not Available recruiting NCT02841241
Esmolol Infusion for Patients With Septic Shock and Persistent Tachycardia treatment 2 completed NCT05627817
Timing of Preload Responsiveness in Sepsis No drug interventions Not Available Not Available recruiting NCT04773717
The Effect of High Dose Parenteral Ascorbic Acid On Microcirculation In Sepsis treatment Not Available completed NCT01332734
Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis Not Available Not Available completed NCT01486524
Pharmacogenomic Biomarker Study for Recombinant Human Activated Protein C Treatment in Severe Sepsis No drug interventions Not Available Not Available unknown_status NCT01144624
A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock No drug interventions treatment 2 completed NCT05591924
Early Severe Illness TrAnslational BioLogy InformaticS in Humans No drug interventions Not Available Not Available not_yet_recruiting NCT04203524
Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients With Sepsis No drug interventions diagnostic Not Available unknown_status NCT04134624
EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock No drug interventions treatment Not Available terminated NCT06504316
OXiris for Abdominal SEptic Shock (OASES Study) No drug interventions treatment Not Available not_yet_recruiting NCT05630716
Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotension and/or Septic Shock No drug interventions supportive_care Not Available recruiting NCT00819416
Fluid Resuscitation in Early Septic Shock treatment 2 completed NCT03708796
DIAGNOSis of Infection in Emergency Department No drug interventions Not Available Not Available completed NCT02135796
Echocardiography in Septic Shock No drug interventions Not Available Not Available unknown_status NCT04748796
Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility treatment Not Available recruiting NCT01315496
GCIV as an Adjuvant Therapy for Community-Acquired Severe Sepsis or Septic Shock No drug interventions treatment 3 terminated NCT02771158
Midodrine During Recovery From Septic Shock supportive_care 4 withdrawn NCT04961658
Advanced Mesenchymal Enhanced Cell THerapY for SepTic Patients No drug interventions treatment 1 terminated NCT06005558
Low Dose Versus High Dose Methylene Blue in Septic Patients treatment 2 / 3 completed NCT06225258
Xanthohumol as an Adjuvant in the Treatment of Septic Shock No drug interventions treatment 2 recruiting NCT06152458
Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock. treatment 4 completed NCT03085758
Treatment of Patients With Early Septic Shock and Bio-Adrenomedullin(ADM) Concentration > 70 pg/ml With ADRECIZUMAB treatment 2 completed NCT01363635
Severe Sepsis/Septic Shock on Admission to the General Surgical ICU No drug interventions Not Available Not Available recruiting NCT00510835
Protocolized Care for Early Septic Shock No drug interventions treatment Not Available completed NCT04143035
Hemodynamic Resuscitation and Monitoring in Early Sepsis No drug interventions Not Available Not Available active_not_recruiting NCT06144463
Lung Ultrasound-guided Fluid Resuscitation in Neonatal Septic Shock No drug interventions treatment Not Available completed NCT01724463
Electronic Application of a Severe Sepsis Screening Tool and Management Bundle No drug interventions Not Available Not Available unknown_status NCT05383963
Evaluation of Parameters Collected From Routine Data for the Diagnosis of Sepsis and Septic Shock and Their Influence on Time to Diagnosis and Patient Outcome No drug interventions Not Available Not Available recruiting NCT01222663
Effects of Hemoperfusion With a Polymyxin B Membrane in Peritonitis With Septic Shock No drug interventions treatment 3 completed NCT06010186
Evolution of Muscle Function, Breathlessness and Quality of Life Following Intra or Extra-Abdominal Sepsis in ICU Patients No drug interventions other Not Available recruiting NCT03835286
Vitamin C to Reduce Vasopressor Dose in Septic Shock treatment 3 withdrawn NCT00197886
Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock. treatment Not Available completed NCT04855786
External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients No drug interventions treatment Not Available active_not_recruiting NCT05357339
Microcirculation Properties of Albumin for Fluid Resuscitation in Septic Shock No drug interventions treatment Not Available unknown_status NCT06217939
Early Intravenous Hydrocortisone in Sepsis treatment Not Available recruiting NCT02306239
The Effect of Terlipressin on Intesitnal Function in Septic Shock Patients treatment Not Available unknown_status NCT00995839
Terlipressin in Septic Shock: Effects on Microcirculation treatment 2 / 3 completed NCT03946839
Functional Magnetic Resonance Imaging (fMRI) of Brain in ICU Survivors With Cognitive Impairment No drug interventions Not Available Not Available completed NCT01722422
Hyperoxia and Hypertonic Saline in Septic Shock No drug interventions treatment Not Available terminated NCT06072222
Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation treatment 1 / 2 completed NCT05042622
Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure No drug interventions treatment Not Available unknown_status NCT05761522
Cardiovascular Effects of Norepinephrine No drug interventions Not Available Not Available recruiting NCT04111822
Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock treatment 3 completed NCT03831022
Usefulness of Capillary Refill Time and Skin Mottling Score to Predict Intensive Care Unit Admission No drug interventions Not Available Not Available unknown_status NCT00707122
Volume Replacement With Albumin in Severe Sepsis No drug interventions treatment 3 completed NCT03013322
Anticholium® Per Se treatment Not Available completed NCT04931225
LANdiolol MIcrocirculatory Effects During Septic chOc (MILANOS) treatment 3 recruiting NCT02453425
The Effects of Blood Pressure on Renal Function and Oxygenation in Septic Shock No drug interventions prevention Not Available completed NCT05921825
Red Cell Distribution Width and Lactate Albumin Ratio as Prognostic Markers for Mortality in Sepsis and Septic Shock No drug interventions Not Available Not Available not_yet_recruiting NCT03861325
Acute Intestinal Failure in Critically Ill Patients and Microbial Translocation No drug interventions Not Available Not Available completed NCT01319630
The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients No drug interventions Not Available Not Available completed NCT03177330
Safety and Efficacy of Heparin Dosing Score Protocol for Polymyxin-B Hemoperfusion No drug interventions Not Available Not Available unknown_status NCT03837730
Citrulline and Arginase Activity in Severe Sepsis and Septic Shock No drug interventions Not Available Not Available unknown_status NCT00698048
Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock No drug interventions Not Available Not Available completed NCT03987048
Cirrhotic Patients With Septic Shock No drug interventions Not Available Not Available completed NCT04449757
Bicarbonated Ringer's Solution Versus Lactated Ringer's Solution in Patients With Septic Shock treatment Not Available unknown_status NCT03208257
Esmolol to Control Adrenergic Storm in Septic Shock- ROLL-IN 2 treatment 2 unknown_status NCT05315557
Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics With Septic Shock- the VITEL-C Trial treatment Not Available unknown_status NCT00837057
Early Continuous Renal Replacement Therapies (CRRT) in Patients With Severe Sepsis or Septic Shock With Acute Kidney Injury No drug interventions treatment 4 unknown_status NCT02576457
Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis No drug interventions treatment 1 terminated NCT05818826
Early Versus Conventional Cessation of Hydrocortisone in Septic Shock treatment 2 recruiting NCT02558166
Renal Resistive Index in Patients With Shock No drug interventions Not Available Not Available completed NCT03378466
Heparin Anticoagulation in Septic Shock treatment 2 terminated NCT02961166
Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARDS) Patients Not Available Not Available completed NCT02780466
Observational Study on Intubation in Septic Shock No drug interventions Not Available Not Available completed NCT05453565
Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis No drug interventions Not Available Not Available not_yet_recruiting NCT03452865
Esomeprazole to Reduce Organ Failure in Sepsis treatment 3 completed NCT03617965
Mortality Due to Septic Shock Associated With Thrombocytopenia No drug interventions Not Available Not Available unknown_status NCT04319965
Complications Related to Transpulmonary Thermodilution No drug interventions Not Available Not Available unknown_status NCT06180265
The Diagnostic and Prognostic Value of Presepsin in Sepsis No drug interventions diagnostic Not Available completed NCT04494074
Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock No drug interventions treatment Not Available recruiting NCT03898674
Microcirculatory Guided Goal Directed Fluid Therapy in Septic Shock; a Feasibility Study No drug interventions treatment Not Available unknown_status NCT05688774
Study of Progression of Community Acquired Pneumonia in the Hospital in Patients With More Severe Preexisting Diseases and Immunosuppression No drug interventions Not Available Not Available recruiting NCT03270774
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units No drug interventions Not Available Not Available completed NCT01775020
Dose-response Study of Arginine Supplementation in Severe Sepsis No drug interventions Not Available 0 completed NCT05231720
Mannheim Register of Sepsis and Septic Shock No drug interventions Not Available Not Available unknown_status NCT02336620
Balanced Salt Solution VS. Normal Saline Solution in Septic Shock No drug interventions treatment 3 completed NCT03920982
Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients. No drug interventions diagnostic Not Available recruiting NCT02748382
Fluids in Sepsis and Septic Shock No drug interventions treatment 2 / 3 completed NCT00629382
Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis No drug interventions treatment 4 completed NCT01393782
Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study treatment 1 completed NCT01526382
Use of PiCCO System in Critically Ill Patients With Septic Shock and Acute Respiratory Distress Syndrome No drug interventions treatment 1 / 2 completed NCT06531031
Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples No drug interventions Not Available Not Available not_yet_recruiting NCT02346331
Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya No drug interventions treatment Not Available completed NCT06471231
Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock prevention 4 recruiting NCT02060773
Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock No drug interventions Not Available Not Available unknown_status NCT02478073
Piperacillin Pharmacokinetics in ICU Patients No drug interventions Not Available Not Available unknown_status NCT04031573
Ivabradine for Heart Rate Control In Septic Shock treatment 3 recruiting NCT03344627
Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients treatment Not Available completed NCT03308227
Plasma and Lung Tissue Concentrations of Linezolid in Septic Shock Patients No drug interventions Not Available Not Available unknown_status NCT01947127
Venous Lactate in Progression to Overt Septic Shock and Mortality in Non-elderly Sepsis Patients in Emergency Department No drug interventions Not Available Not Available completed NCT02972827
Monitoring Devices in Prediction of Fluid Responsiveness in Severe Sepsis and Septic Shock No drug interventions diagnostic Not Available unknown_status NCT04991376
Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment No drug interventions Not Available Not Available completed NCT01612676
Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock treatment 2 completed NCT03882476
RCT of Sepsis Machine Learning Algorithm No drug interventions diagnostic 2 withdrawn NCT01920776
Focused Ultrasound in Septic Shock Patients No drug interventions treatment Not Available unknown_status NCT02025660
Efficacy of Mw Vaccine in Treatment of Severe Sepsis No drug interventions treatment 2 / 3 completed NCT00628160
Terlipressin in Septic Shock in Cirrhosis treatment 2 / 3 completed NCT02566460
The Effect of Lactate Clearance Oriented Haemodynamic Therapy on the Outcome of Patients With Septic Shock No drug interventions treatment Not Available completed NCT04683094
Comparative Study for the Validity of Various Severity Scoring System No drug interventions Not Available Not Available completed NCT05707494
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Sepsis No drug interventions treatment Not Available recruiting NCT04204694
Study of the Role of Interferon αon the Endothelial Dysfunction During Septic Shock No drug interventions Not Available Not Available unknown_status NCT01443494
High MAP in Septic Shock With Hypertension No drug interventions treatment Not Available completed NCT04231994
Therapeutic Plasmaexchange in Early Septic Shock No drug interventions treatment 2 completed NCT03961594
Evaluation of New Hemodynamic Indices No drug interventions other Not Available unknown_status NCT02085291
Effect of Different Strategies for Titrating a High MAP on Microcirculation treatment 4 completed NCT02856191
Study on the Frequency of de Novo Atrial Fibrillation in Septic Shock in Medical Intensive Care No drug interventions Not Available Not Available completed NCT04114162
Fluid Overload Quantification in Septic Shock No drug interventions Not Available Not Available unknown_status NCT01013662
Lipid Profile in Patients With Severe Sepsis or Septic Shock Under Strict or Liberal Glycemic Control No drug interventions screening Not Available completed NCT05741762
Assessing Baseline Cortisol Levels in Patients Admitted With Septic Shock in Intensive Care Unit No drug interventions Not Available Not Available active_not_recruiting NCT04492280
Evaluation of the Role of Hydrocortisone Either Alone or Combined With Fludrocortisone in the Outcome of Septic Shock in Adults prevention 4 completed NCT05629780
Temporal Changes of Lactate in CLASSIC Patients No drug interventions basic_science Not Available completed NCT06537180
Gender-based Differences in the Outcome of the Treatment of Persistent Septic Shock With Hydrocortisone No drug interventions Not Available Not Available completed NCT05972980
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients No drug interventions Not Available Not Available completed NCT00329680
The Effects of Eicosapentaenoic Acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants in the Treatment of Sepsis No drug interventions treatment 4 completed NCT03828929
Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock treatment 3 terminated NCT01371929
Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study No drug interventions Not Available Not Available terminated NCT01780129
Polydatin Injectable (HW6) for Shock Treatment treatment 2 unknown_status NCT04079829
Postoperative Respiratory Abnormalities No drug interventions Not Available Not Available unknown_status NCT04494789
Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS treatment 2 completed NCT03765489
Electrical Muscle Stimulation in the Development of Acquired Weakness in Patients With Severe Sepsis and Septic Shock No drug interventions prevention Not Available completed NCT03752489
Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment No drug interventions diagnostic 2 unknown_status NCT04665089
Erythromycin in Septic Patients: Immunomodulatory Role and Clinical Impact treatment Not Available completed NCT01296789
Comparison of a Tissue Perfusion Guided Hemodynamic Protocol With a Standard Hemodynamic Protocol in Septic Shock Patients No drug interventions treatment Not Available terminated NCT02266589
Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock treatment 3 completed NCT03280992
Community Acquired Sepsis Cohort No drug interventions Not Available Not Available terminated NCT06234592
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock other Not Available not_yet_recruiting NCT04870892
Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock No drug interventions Not Available Not Available unknown_status NCT01665092
Rapid Administration of Carnitine in sEpsis treatment 2 completed NCT06124092
Outcomes of Children After Hospitalization in Intensive Care Unit No drug interventions Not Available Not Available not_yet_recruiting NCT05886192
The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients treatment 4 recruiting NCT02731144
Optimized Caloric-proteic Nutrition in Septic and Septic Shock Patients No drug interventions treatment 4 terminated NCT00384644
Skeletal Muscle Oxygenation in Critically Ill No drug interventions Not Available Not Available unknown_status NCT04123444
Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in Patients With Septic Shock Suffering From Organ Failure treatment 2 / 3 completed NCT00207844
Selenium, as Sodium Selenite, in the Treatment of Septic Shock treatment 2 completed NCT02034240
Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis? No drug interventions Not Available Not Available completed NCT06532240
Methylene Blue for the Treatment of Septic Shock treatment 3 recruiting NCT05895240
Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality prevention 4 recruiting NCT02580240
Initiation of Hydrocortisone for the Treatment of Septic Shock treatment Not Available completed NCT00450840
Simvastatin in Patients With Septic Shock treatment 4 unknown_status NCT02768740
Hydrocortisone 50 mg Every 6 Hours Compared to Hydrocortisone 300 mg Per Day in Treatment of Septic Shock. treatment 4 completed NCT03990467
Observed Pharmacokinetic of Piperacillin/Tazobactam Compared to Amikacin in ICU treatment Not Available unknown_status NCT06008067
The Prognostic Role of Tricuspid Annular Plane Systolic Excursion in Critically Ill Patients With Septic Shock No drug interventions Not Available Not Available completed NCT04259567
Improvement of Cerebrovascular Autoregulation in Patients With Septic Shock Due to Cytokine Elimination No drug interventions treatment Not Available unknown_status NCT04553367
Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation treatment 1 / 2 completed NCT06499467
Norepinephrine Equivalent Dose of Vasopressin, Phenylephrine and Epinephrine in Septic Shock No drug interventions Not Available Not Available recruiting NCT03475667
Comparison of Radial and Femoral Artery Site Invasive Blood Pressure Measurement in Septic Shock Patients No drug interventions Not Available Not Available completed NCT04005001
Machine Learning Sepsis Alert Notification Using Clinical Data No drug interventions other 2 unknown_status NCT00093301
Levosimendan Versus Dobutamine in Shock Patients treatment 2 / 3 unknown_status NCT04844801
Rate, Rhythm or Risk Control for New-onset Supraventricular Arrhythmia During Septic Shock: a Randomized Controlled Trial No drug interventions treatment Not Available unknown_status NCT00327704
Early Albumin Resuscitation During Septic Shock treatment 4 completed NCT00481572
Continuous Infusion of Terlipressin in Septic Shock treatment 2 completed NCT04057872
Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis No drug interventions other 1 active_not_recruiting NCT06581172
Significance of Disseminated Intravascular Coagulation Score in Mortality for Children With Shock No drug interventions Not Available Not Available not_yet_recruiting NCT01929772
German Lactat Clearance in Severe Sepsis No drug interventions Not Available Not Available completed NCT00046072
A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis treatment 2 completed NCT01231672
Prospective Validation of Clini-biological Parameters Including Initial Hemostasis, Which Improve the Prediction of Death at 1 Month Among Patients With Septic Shock No drug interventions Not Available Not Available completed NCT03077672
Mitochondrial DNA as a Biomarker of Sepsis Severity No drug interventions Not Available Not Available completed NCT04948372
Effects of Terlipressin on Renal Perfusion in Patients With Septic Shock treatment Not Available completed NCT04459572
As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR No drug interventions diagnostic Not Available completed NCT03913468
Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine. Not Available Not Available completed NCT02885168
Modulation of Vasoreactivity in Septic Shock: Impact of Recombinant Protein C treatment 4 completed NCT03640468
Lidocaine as an Adjuvant for Ketamine in Induction of Anesthesia in Septic Shock Patients treatment 3 unknown_status NCT00258869
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests No drug interventions Not Available Not Available unknown_status NCT03029169
Propafenone Versus Amiodarone in Septic Shock treatment 4 completed NCT04013269
Adjuvant Therapy With CytoSorb in Refractory Septic Shock No drug interventions treatment Not Available recruiting NCT02990546
Midodrine in the Recovery Phase of Septic Shock treatment 3 withdrawn NCT02600312
Comparing Cytokines, Toxins Adsorbing oXiris Filter to ST150 Filter During CRRT in Patients With Septic Shock No drug interventions treatment Not Available completed NCT05358912
Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock No drug interventions prevention 4 completed NCT05310812
Evaluation of Candidate Biomarkers to Predict Disease Severity and Acute Kidney Injury in Sepsis Patients No drug interventions Not Available Not Available completed NCT06155812
Multimodal Vasopressor Strategy in Septic Shock No drug interventions treatment 2 / 3 recruiting NCT05208112
Intravenously Administered M6229 in Critically Ill Sepsis Patients No drug interventions treatment 1 completed NCT04141410
Global Longitudinal Strain Assessment in Cardiogenic Shock During Sepsis Not Available Not Available unknown_status NCT01070810
Thiamine as a Metabolic Resuscitator in Septic Shock treatment 1 / 2 completed NCT01063010
Pilot Study of Bevacizumab (Avastin) in Patients With Septic Shock treatment Not Available withdrawn NCT06330610
Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care Unit No drug interventions supportive_care Not Available not_yet_recruiting NCT03716310
Platelet Reactivity in Septic Shock No drug interventions Not Available Not Available completed NCT02270281
Dexmedetomidine on Microcirculation in Septic Shock treatment 4 completed NCT02612181
Dex on Microcirculation in SS-A Double-blinded Study treatment 4 unknown_status NCT04449081
Knowledge, Attitude and Practice of Dental Students About COVID-19 No drug interventions Not Available Not Available completed NCT05327881
Serum Rennin Kinetics Versus Serum Lactate Kinetics as Predictors of Mortality in Septic Shock Patients No drug interventions Not Available Not Available unknown_status NCT06224881
Vitamin C Deficiency in Septic Shock supportive_care 4 completed NCT03884595
Early Identification of Sepsis in Children No drug interventions Not Available Not Available unknown_status NCT02871895
Application of Biomarkers Change to Predict Outcome of Patient With Severe Sepsis No drug interventions Not Available Not Available unknown_status NCT04231695
Extracorporeal Cytokine Removal in Patients With Septic Shock in an Adult Intensive Care Unit No drug interventions Not Available Not Available unknown_status NCT02246595
Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction treatment 2 completed NCT04710914
Comparison of Extubation Delay After Prolonged Sedation treatment 4 unknown_status NCT04952714
RRT With a Cytokine Absorption Filter (oXiris ®) in Patients With Septic Shock No drug interventions Not Available Not Available completed NCT03685214
Comparison of Balanced Crystalloids and Normal Saline in Septic Patients treatment Not Available unknown_status NCT03547414
Does Urinary TIMP2 and IGFBP7 Can Identify High Risk Patients of Progression From Mild and Moderate to Severe Acute Kidney Injury During Septic Shock? No drug interventions Not Available Not Available unknown_status NCT02918214
Prognostic Assessment of Diastolic and Systolic Left Ventricular Function in Septic Shock No drug interventions Not Available Not Available completed NCT03480555
Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients No drug interventions other Not Available completed NCT03055455
Neuroimaging and Neuromonitoring in Critically Ill Children With Sepsis No drug interventions Not Available Not Available completed NCT03189355
Expression of Protein Tyrosine Phosphatase 1B (PTP1B) and Body Composition Modification in Patients With Septic Shock No drug interventions prevention Not Available unknown_status NCT05694455
Micro and Macro Circulation in Sepsis No drug interventions basic_science Not Available recruiting NCT02734550
(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis No drug interventions diagnostic Not Available completed NCT03302650
Angiotensin II for Septic Shock Treatment treatment 3 suspended NCT05428423
Reliability of PVI Changes During Tidal Volume Challenge in ICU Patients No drug interventions Not Available Not Available recruiting NCT00407823
Comparison of Pediatric Septic Shock Treatment With and Without Central Venous Oxygen Saturation Monitoring No drug interventions treatment Not Available completed NCT04693923
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients No drug interventions diagnostic Not Available unknown_status NCT00823108
Rapid Administration of Insulin in Sepsis No drug interventions treatment 1 completed NCT00197938
Lactic Acid in the Rectum and Life-Threatening Infection No drug interventions Not Available Not Available completed NCT03457038
Use of Fc-MBL to Detect and Monitor the Presence of PAMPs During Septic Shock No drug interventions diagnostic Not Available unknown_status NCT05202938
eMESH Struct. 2022-23 No drug interventions Not Available Not Available recruiting NCT04901338
Cytokine Hemoadsorption in ECMO Patients No drug interventions Not Available Not Available completed NCT02899143
Short-course Antimicrobial Therapy in Sepsis No drug interventions treatment 2 unknown_status NCT03727243
Molecular Diagnosis and Risk Stratification of Sepsis in India No drug interventions Not Available Not Available unknown_status NCT04934943
"Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools" No drug interventions Not Available Not Available unknown_status NCT03297203
Innate Lymphoid Cells in Septic Shock No drug interventions other Not Available completed NCT03038503
What Should be the Next Vasopressor for Severe Septic Shock? Methylene Blue or Terlipressin treatment 3 unknown_status NCT00001303
Effects of Endotoxin in Normal Human Volunteers treatment 1 completed NCT01223690
Clarithromycin as Immunomodulator for the Management of Sepsis treatment 3 completed NCT01841190
Prognostic Evaluation Of Severe Sepsis And Septic Shock. Procalcitonin Versus Delta Sofa No drug interventions Not Available Not Available unknown_status NCT01682590
I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit) No drug interventions other 3 terminated NCT05296590
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia No drug interventions Not Available Not Available active_not_recruiting NCT00118664
Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in Children No drug interventions Not Available Not Available completed NCT03193164
Neuromuscular Electrical Stimulation and Septic Shock No drug interventions treatment Not Available suspended NCT05552521
Diastolic Dysfunction in Septic Shock and Cardiomyopathy Genetic Variants No drug interventions Not Available Not Available completed NCT04834921
MCO Membrane Efficiency in Septic Shock Patients No drug interventions supportive_care Not Available completed NCT00535821
Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock No drug interventions treatment 4 terminated NCT03805321
The Validity of Peripheral Perfusion Index to Predict Fluid Responsiveness No drug interventions Not Available Not Available completed NCT03736421
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients No drug interventions Not Available Not Available suspended NCT04107402
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock No drug interventions basic_science Not Available unknown_status NCT01493102
Discontinuation Order of Vasopressors in Septic Shock supportive_care Not Available terminated NCT00372502
Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation No drug interventions treatment Not Available completed NCT06227702
Vexus-guided Fluid Management in Patients With Septic Shock After the Resuscitation Phase No drug interventions treatment Not Available not_yet_recruiting NCT05787184
Sepsis Early EvaluatioN Through Rapid Ultrasound and veNous Gas Analysis No drug interventions Not Available Not Available recruiting NCT04302584
Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock treatment Not Available completed NCT04316884
Mechanisms for Organ Dysfunction in Covid-19 No drug interventions Not Available Not Available recruiting NCT02421484
Cellular Immunotherapy for Septic Shock: A Phase I Trial treatment 1 completed NCT05060679
Presepsin:Gelsolin Ratio in Sepsis-related Organ Dysfunction No drug interventions Not Available Not Available completed NCT05172479
Prognostic Accuracy of qSOFA, SIRS, and EWSs for In-hospital Mortality in Emergency Department No drug interventions Not Available Not Available completed NCT04203979
Sepsis: From Syndrome to Personalized Care No drug interventions Not Available Not Available recruiting NCT02638779
REAnimation Low Immune Status Markers No drug interventions diagnostic Not Available completed NCT02706379
Impact of Early Goal-Directed Therapy to Perfusion and Metabolism of Brain No drug interventions treatment Not Available unknown_status NCT05968287
Can Measurement of Neutrophil-derived ROS Production be a Novel Biomarker of Sepsis? No drug interventions Not Available Not Available completed NCT01329887
The Effect of Ketanserin on the Microcirculation in Sepsis treatment 3 completed NCT00534287
Comparison of Two Antibiotic Regimen (Meropenem Versus Meropenem+Moxifloxacin)in the Treatment of Severe Sepsis and Septic Shock treatment 3 completed NCT05645887
Human Albumin Treatment in Adult Septic Shock. A Study Evaluating Immune Response and Organ Failure. treatment 2 withdrawn NCT06122987
Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock treatment 4 recruiting NCT03710187
HCT+F vs. HCT Alone in Critically Ill Medical Septic Shock Patients treatment 2 completed NCT03104933
Proadrenomedullin and Copeptin in Patients With Septic Shock No drug interventions Not Available Not Available completed NCT03926533
TelePORT Pilot Study No drug interventions health_services_research Not Available completed NCT02357433
Mortality Reduction in Septic Shock by Plasma Adsorption No drug interventions other Not Available terminated NCT05065333
Implementation Trial of Predictive Modeling to Enhance Diagnosis and Improve Treatment in Pediatric Septic Shock No drug interventions diagnostic Not Available completed NCT02655133
Effects on Microcirculation of IgGAM in Severe Septic/Septic Shock Patients. treatment 2 completed NCT01957254
Investigate the Activity of Endotoxin in Severe Sepsis No drug interventions Not Available Not Available terminated NCT04884854
Efferon LPS Hemoperfusion for Treatment of Patients With Septic Shock No drug interventions Not Available Not Available completed NCT02635854
Study of Platelet Activation in Septic Shock Patients No drug interventions basic_science Not Available completed NCT06366854
UK ANDROMEDA-Shock-2 RCT No drug interventions treatment Not Available not_yet_recruiting NCT03065751
Plasmaexchange in Early Septic Shock No drug interventions treatment Not Available unknown_status NCT01604551
Membrane Shedding During Septic Shock No drug interventions Not Available Not Available completed NCT04156451
Effect of Fluid Deresuscitation With Central Venous Pressure Target 0-4 mmHg in Septic Shock Patients No drug interventions treatment Not Available unknown_status NCT05039151
Interstitial Fluid Composition in Patients With Septic Versus Non-septic Shock: an Exploratory Pilot Study No drug interventions Not Available Not Available recruiting NCT03395951
Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients No drug interventions Not Available Not Available completed NCT02692053
Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers No drug interventions diagnostic Not Available unknown_status NCT04080453
Pro-inflammatory Role of Blood Platelets in Critically Ill Patients With Septic Shock. No drug interventions Not Available Not Available completed NCT05402553
The Efficacy of Adjunctive Use of Ondansetron in Patients With Sepsis and Septic Shock treatment 1 / 2 recruiting NCT02664753
L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury treatment 3 recruiting NCT01817153
Effect of Hydrocortison on Post-ischemic Flow-mediated Dilation and on Thenar Oxygen Saturation in Human Septic Shock. No drug interventions treatment 2 / 3 terminated NCT02681653
Study the Impact of Statins in Septic Shock treatment Not Available completed NCT03277677
The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients No drug interventions treatment 3 completed NCT03953677
Evaluation of the Effect of Dexmedetomidine on Phenylephrine Response During Refractory Septic Shock treatment 3 terminated NCT02240277
Meropenem and Ciprofloxacin Dosing in Septic Shock No drug interventions Not Available Not Available unknown_status NCT03592277
Vitamin C & Thiamine to Treat Sepsis and Septic Shock treatment 2 completed NCT01263977
Thermodilution - Controlled Management of Volume Therapy in Septic Shock No drug interventions treatment Not Available completed NCT04281277
Relation Between Mean Arterial Pressure and Renal Resistive Index in the Early Phase of Septic Shock No drug interventions other Not Available recruiting NCT06140147
Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients No drug interventions treatment Not Available recruiting NCT01943747
International Multicentre Prevalence Study on Sepsis No drug interventions Not Available Not Available completed NCT06394947
Fluid Challenge in Intensive Care The FENICE II Study No drug interventions Not Available Not Available not_yet_recruiting NCT02638545
Hemodynamic Effects of Dexmedetomidine in Septic Shock treatment 3 completed NCT04530045
Target Attainment of TDM-guided Infusion of Piperacillin/Tazobactam and Cefepim in Critically Ill Patients No drug interventions Not Available Not Available completed NCT00523198
Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock No drug interventions Not Available Not Available completed NCT00406198
Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis No drug interventions supportive_care 4 completed NCT06302998
Dexmedetomidine and Vasopressin in Septic Shock treatment 2 not_yet_recruiting NCT05270798
Thyroid Hormone Supplementation in Patients With Septic Shock treatment 2 completed NCT04774705
Effectiveness of Non-invasive Vagus Nerve Stimulation as an Adjuvant Treatment in Patients With Sepsis in Intensive Care. No drug interventions other Not Available recruiting NCT03340805
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study other 1 completed NCT06043505
Impact of an Echographic Algorithm on Hemodynamic Optimization in the First 4 Days of Septic Shock Management No drug interventions other Not Available recruiting NCT04903405
Immune Function Monitoring and Immunotherapy in Sepsis No drug interventions Not Available Not Available unknown_status NCT02699905
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis No drug interventions Not Available Not Available withdrawn NCT03762005
Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock No drug interventions treatment Not Available unknown_status NCT00676897
Statin Therapy in the Treatment of Sepsis treatment 2 / 3 completed NCT02899897
Place of Echocardiography in IV Fluid Therapy in Patients With Septic Shock and Left Ventricular Systolic Dysfunction No drug interventions Not Available Not Available completed NCT02934997
The Role of Dysfunctional HDL in Sepsis No drug interventions Not Available Not Available completed NCT03438097
Survey of Non-resuscitation Fluids in Septic Shock No drug interventions Not Available Not Available completed NCT02399397
Influence of Age, Sepsis and SLCO1A2 Polymorphisms on Rocuronium Pharmacokinetics treatment 4 completed NCT06518083
The Relation Between Triglyceride- Glucose Index, Procalcitonin and Cardiac Affection in Septic Shock. No drug interventions Not Available Not Available not_yet_recruiting NCT02750683
Norepinephrine Exerts an Inotropic Effect at the Early Phase of Human Septic Shock No drug interventions Not Available Not Available completed NCT05557461
Assessment of Fluid Responsiveness in Septic Shock Patients, Can End-tidal co2 Measurement Help? No drug interventions Not Available Not Available recruiting NCT06145828
Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock No drug interventions Not Available Not Available recruiting NCT02361528
GM-CSF to Decrease ICU Acquired Infections treatment 3 completed NCT01988428
Prehospital Antibiotics Against Sepsis Trial treatment Not Available completed NCT02306928
PK Analysis of Piperacillin in Septic Shock Patients No drug interventions Not Available Not Available completed NCT01806428
Activated Protein C and Microcirculation No drug interventions Not Available Not Available completed NCT03434028
Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis treatment 3 completed NCT02884011
Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock No drug interventions Not Available Not Available completed NCT04515511
Whether a Minimal Volume Could Predict Fluid Responsiveness Using Thermodilution by PAC in Septic Shock Patients No drug interventions diagnostic Not Available unknown_status NCT00934011
Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections No drug interventions treatment Not Available completed NCT05057611
Hemodynamic Phenotype and Capillary Refill Time-targeted Resuscitation Strategy No drug interventions treatment Not Available recruiting NCT03872011
Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock treatment 3 completed NCT03198611
Reversibility of Diastolic Disfunction in Septic Shock No drug interventions Not Available Not Available unknown_status NCT04977011
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient No drug interventions supportive_care Not Available completed NCT04295993
Methylene Blue and Microcirculation in Septic Shock treatment 3 unknown_status NCT01188993
Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock No drug interventions diagnostic 4 completed NCT03847493
Analysis of Sublingual Glycocalyx Damage at ICU Admission to Predict Risk of Death No drug interventions Not Available Not Available unknown_status NCT04346693
An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19 No drug interventions treatment 3 completed NCT03634293
Treatment of Severe Infection With Antihyperlipidemia Drug treatment 2 / 3 unknown_status NCT03592693
Vitamin C, Hydrocortisone and Thiamine for Septic Shock treatment 2 recruiting NCT03246893
Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients No drug interventions prevention Not Available completed NCT00332371
COMPACT - COMbining Plasma-filtration and Adsorption Clinical Trial No drug interventions treatment Not Available terminated NCT03837171
TRANSfusion in Patients With Onco-hematological Malignancies ResusciTated From Septic Shock No drug interventions treatment 3 completed NCT02464371
Interest of Plasma microRNAs No drug interventions Not Available Not Available completed NCT01839578
Citrate Versus Heparin Anticoagulation: Effect on Molecules Clearances treatment Not Available unknown_status NCT03333278
The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial treatment 2 completed NCT03122678
Thiamine Supplementation in Patients With Septic Shock treatment 1 withdrawn NCT05991778
Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients No drug interventions Not Available Not Available completed NCT03589378
Therapeutic Plasma Exchange Adsorption Diafiltration No drug interventions treatment Not Available unknown_status NCT06370078
Effect of Early Administration of Albumin 20% Versus Crystalloid treatment Not Available recruiting NCT03992378
Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis No drug interventions treatment Not Available recruiting NCT02069288
Effects of Fludrocortisone on Norepinephrine-mean Arterial Pressure Dose-response in Septic Shock treatment 3 withdrawn NCT01312688
Early Goal-directed Therapy and Myocardial Dysfunction No drug interventions treatment Not Available unknown_status NCT05289388
a Novel Index for Tissue Perfusion in Predicting Outcome in Patients With Septic Shock No drug interventions Not Available Not Available unknown_status NCT00592488
Acetyl-L-Carnitine in the Treatment of Septic Shock treatment 1 / 2 completed NCT05249088
Protocolized Reduction of Non-resuscitation Fluids vs Usual Care in Septic Shock Feasibility Trial No drug interventions other Not Available completed NCT05658588
Hemodynamic Impact of Cytosorb and CKRT in Children With Septic Shock No drug interventions treatment Not Available completed NCT05833607
Effects of Targets of Blood Pressure on Cerebral Hemodynamics in Septic Shock No drug interventions Not Available Not Available recruiting NCT03901807
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study No drug interventions treatment Not Available recruiting NCT01827007
Assessment of Fluid Responsiveness by Elevation of PEEP in Patients With Septic Shock No drug interventions treatment Not Available completed NCT00335907
Protocol-driven Hemodynamic Support for Patients With Septic Shock No drug interventions treatment Not Available unknown_status NCT01973907
Pilot Study for the SQUEEZE Trial No drug interventions treatment 3 completed NCT03713307
Macro and Micro Haemodynamic Responses to Shock in the Renal and Systemic - MICROSHOCK - RENAL No drug interventions Not Available Not Available unknown_status NCT03020407
The Randomized Controlled Trial of Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation treatment Not Available completed NCT04055909
Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock treatment 2 active_not_recruiting NCT03989609
Dexmedetomidine in Modifying Immune Paralysis In Patient With Septic Shock treatment 2 completed NCT05088109
Shock Indices Use for Early Mortality From Septic Shock No drug interventions Not Available Not Available recruiting NCT01585909
Evaluation of Intestinal Brush Border Enzyme Function in Critically Ill Patients No drug interventions diagnostic Not Available completed NCT04470856
Carotid Doppler and EEOT for Fluid Responsiveness Prediction No drug interventions diagnostic Not Available completed NCT03715556
Control Versus Liberal Cardiac Frequency in Patients in Sepse With Atrial Fibrillation of High Ventricular Response treatment 3 unknown_status NCT06500156
Metabolic Cluster Analysis in Septic Shock Patients No drug interventions Not Available Not Available recruiting NCT00962156
Scandinavian Starch for Severe Sepsis/Septic Shock Trial treatment 3 completed NCT00269685
Comparison of Vasopressin and Other Pressors in Septic Shock treatment 2 / 3 completed NCT04352985
Evaluating the Use of Polymyxin B Cartridge Hemoperfusion for Patients With Septic Shock and COVID 19 No drug interventions Not Available Not Available no_longer_available NCT00930085
Evaluation of Predictive Proteic Profile on Mortality in the Acute Phase of Septic Shock in Cancer Patients No drug interventions Not Available Not Available completed NCT06121115
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit Not Available Not Available completed NCT01485315
Transfusion-requirements in Septic Shock Trial No drug interventions treatment 3 completed NCT04197115
Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis treatment 3 completed NCT00639015
Phenylephrine in Septic Shock treatment 2 completed NCT06119815
CO2 Gap Changes Versus Inferior Vena Cava Collapsibility in Relation to Cardiac Index as a Prognostic Value in Septic Shock No drug interventions diagnostic Not Available recruiting NCT04239937
Insulin Resistance in Stress-metabolic Medical Patients No drug interventions Not Available Not Available unknown_status NCT04999137
Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa treatment 2 unknown_status NCT03120637
Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue supportive_care 4 completed NCT03748537
Mitochondrial Function in Septic Patients basic_science Not Available completed NCT01849237
Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia No drug interventions treatment 1 / 2 unknown_status NCT02668432
Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock treatment 4 terminated NCT03475732
Pharmacokinetics of XueBiJing in Patients With Sepsis No drug interventions treatment Not Available completed NCT05271032
PiCCO ASSESSMENT IN PATIENTS WITH SEPTIC SHOCK No drug interventions Not Available Not Available completed NCT01284452
Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) treatment Not Available completed NCT00159952
Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock No drug interventions treatment 2 / 3 completed NCT04227652
Control of Fever in Septic Patients treatment Not Available completed NCT04015752
Sepsis in ICU:Causes and Outcomes of Sepsis in Diabetics Versus Non Diabetics in Assiut University Hospital No drug interventions Not Available Not Available unknown_status NCT03461900
Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock No drug interventions treatment Not Available completed NCT01106300
Musculoskeletal Ultrasound Study in Critical Care: Longitudinal Evaluation No drug interventions Not Available Not Available completed NCT05257759
Use of Neurostimulation as a Tool for Reconditioning the Neuromuscular System of Patients Admitted to the ICU for Septic Shock No drug interventions prevention Not Available recruiting NCT06184659
Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis treatment 4 not_yet_recruiting NCT03799159
Renal Arterial Resistive Index Versus Novel Biomarkers for Early Prediction of Sepsis Associated-acute Kidney Injury No drug interventions Not Available Not Available completed NCT04558359
Renin and Renal Biomarker Response to Angiotensin II treatment 4 completed NCT06156059
Oral Bedtime Melatonin in Critically Ill Patients treatment 4 not_yet_recruiting NCT06169475
Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock treatment Not Available completed NCT02288975
Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study No drug interventions Not Available Not Available completed NCT05093075
Therapeutic Plasma Exchange in Septic Shock: a Pilot Study No drug interventions treatment 2 recruiting NCT02044575
Clock Genes in Patients With Refractory Septic Shock (SeptiClock) - Pilot Study No drug interventions Not Available Not Available completed NCT02053675
Hemodynamic Effects of Vasopressin in Early Septic Shock Stage diagnostic Not Available completed NCT05969275
Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock treatment 2 recruiting NCT02820675
Quality Improvement in Infection COntrol and Sepsis Management in MOdel Regions No drug interventions health_services_research Not Available completed NCT03201575
REmote Ischemic COnditioning in Septic Shock No drug interventions treatment Not Available completed NCT01453270
Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial No drug interventions treatment Not Available completed NCT05349370
Lactate Kinetics in Septic Shock No drug interventions basic_science Not Available recruiting NCT03251170
Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock treatment 4 completed NCT04750070
Management of Shock in Children With SAM or Severe Underweight and Diarrhea treatment 3 unknown_status NCT00793442
Endothelium in Severe Sepsis No drug interventions Not Available Not Available completed NCT02430142
Microcirculatory Oxygen Uptake in Sepsis No drug interventions Not Available Not Available completed NCT05208242
Strong Albumin Solutions in Patients With Septic Shock treatment 2 / 3 recruiting NCT00481442
Phenylephrine Versus Norepinephrine in Septic Shock treatment 2 completed NCT03891342
Effect of Fluid Challenge on Glycocalyx No drug interventions treatment Not Available completed NCT02354742
Echo vs. EGDT in Severe Sepsis and Septic Shock No drug interventions treatment Not Available completed NCT04569942
Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis No drug interventions treatment 3 recruiting NCT02519699
Microcirculation After MAP Increase in Septic Shock Patients With Previous Hypertension treatment 4 completed NCT05386199
The Role of Serotonin in Intensive Care Patients No drug interventions Not Available Not Available recruiting NCT04567199
Influence of Cytosorb on Amount of Catecholamine and Mortality in Sepsis No drug interventions Not Available Not Available completed NCT00320099
Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock treatment 3 completed NCT06415006
Can Shock Indices Be Prognostic Indicators in Sepsis/Septic Shock? No drug interventions Not Available Not Available completed NCT00763906
Norepinephrine Weaning in Septic Patients No drug interventions treatment 4 completed NCT02508649
Selepressin Evaluation Programme for Sepsis-Induced Shock - Adaptive Clinical Trial treatment 2 / 3 terminated NCT06363149
Disseminated Intravascular Coagulation (DIC) Score and Organ Dysfunction in Septic Shock Patients No drug interventions Not Available Not Available recruiting NCT02805049
Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis treatment 4 completed NCT02317549
Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148 treatment 2 terminated NCT03802136
Multiple Biomarkers in ICU Sepsis Patients No drug interventions Not Available Not Available unknown_status NCT02875236
Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81) No drug interventions treatment 4 terminated NCT05143736
Nasal and Gut Microbiota Combined Clinical Events Predicts the Prognosis of Septic Patients No drug interventions Not Available Not Available recruiting NCT02389036
Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients prevention 3 completed NCT05525936
Echocardiographic Evaluation of RV Injury in the ICU No drug interventions Not Available Not Available not_yet_recruiting NCT00684736
Tryptophan, Serotonin and Kynurenine in Septic Shock No drug interventions Not Available Not Available completed NCT04257136
VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock Patients No drug interventions treatment 2 active_not_recruiting NCT05217836
Iron Metabolism Disorders in Patients With Sepsis or Septic Shock. No drug interventions Not Available Not Available unknown_status NCT01067313
Continuous Hemodialysis With an Enhanced Middle Molecule Clearance Membrane No drug interventions treatment 2 / 3 completed NCT02116413
Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock? No drug interventions Not Available Not Available completed NCT05140213
A STUDY BEFORE/AFTER THE IMPLEMENTATION OF AN ANTI-INFECTIOUS PRESCRIPTION AID No drug interventions Not Available Not Available completed NCT03252613
Translational Approaches to Septic Cardiomyopathy No drug interventions Not Available Not Available unknown_status NCT02473718
Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock No drug interventions treatment Not Available completed NCT03258619
Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock Not Available Not Available completed NCT04306419
Observational Trial on Cytokine Adsorption in Sepsis No drug interventions Not Available Not Available recruiting NCT04695119
Sepsis in the ICU-II No drug interventions Not Available Not Available unknown_status NCT00604019
Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock treatment 3 completed NCT04910841
Feasibility of Using the "CGM GUARDIAN 2" Interstitial Fluid Glucose Measurement System in Intensive Care Medicine No drug interventions other Not Available recruiting NCT06226441
Aminoglycoside Administration in Septic Patients No drug interventions treatment Not Available recruiting NCT01856517
Upregulation of Alpha-1 Receptors Upon Septic Shock? diagnostic 2 / 3 terminated NCT01523717
Procalcitonin Monitoring Sepsis Study No drug interventions Not Available Not Available completed NCT05283317
Effect of Mesenchymal Stromal Cells on Sepsis and Septic Shock No drug interventions treatment 1 / 2 completed NCT03911817
Impact of Midodrine Administration on the Clinical Outcome of Septic Shock Patients health_services_research 4 completed NCT01337934
Lactated Ringer Versus Albumin in Early Sepsis Therapy treatment 3 completed NCT05578534
CO2 Gap Changes in Septic Shock in Relation to Cardiac Output No drug interventions Not Available Not Available completed NCT01187134
Medical Education for Sepsis Source Control and Antibiotics No drug interventions other Not Available completed NCT03335124
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock treatment 4 terminated NCT06404424
Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock No drug interventions Not Available Not Available completed NCT01455116
The Cooling And Surviving Septic Shock Study (CASS) No drug interventions treatment 2 / 3 terminated NCT05496816
Coagulation Disturbances in COVID-19 Septic Patients No drug interventions Not Available Not Available completed NCT03817996
Fluid Responsiveness in HFNC Patients No drug interventions Not Available Not Available completed NCT05184296
ExtraCorporeal Membrane Oxygenation in the Therapy for REfractory Septic Shock With Cardiac Function Under Estimated No drug interventions treatment Not Available recruiting NCT03788096
Peer Support for Post Intensive Care Syndrome Self-Management No drug interventions supportive_care Not Available unknown_status NCT03578835
Bloodstream Infection Due to Multidrug-Resistant Organisms - Multicenter Study on Determinants of Clinical Outcomes No drug interventions Not Available Not Available unknown_status NCT04288635
Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical Study No drug interventions Not Available Not Available recruiting NCT04580563
Study Assessing Efficacy of Plasmatherapy in Septic Shock-induced Coagulopathy: Feasibility Study No drug interventions treatment Not Available completed NCT02612363
Early Goal Directed Sedation on Microcirculation in Septic Shock treatment 4 unknown_status NCT02041663
Septic cArdiac Deficiency and MenIngococcal seveRe Sepsis No drug interventions diagnostic Not Available completed NCT03014063
Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock No drug interventions Not Available Not Available completed NCT04963686
Simplified Assessment of Left Ventricular Systolic Function in Septic Shock Patients No drug interventions Not Available Not Available recruiting NCT00378586
Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock No drug interventions Not Available Not Available unknown_status NCT02370186
The Role of Dysfunctional HDL in Severe Sepsis No drug interventions Not Available Not Available completed NCT03974386
Effects of Endotoxin Absorption and Cytokine Removal Hemofilter on Severe Septic Shock No drug interventions treatment Not Available completed NCT04457739
Assessment of Preload Responsiveness in ARDS Patients During Prone Position No drug interventions Not Available Not Available completed NCT00832039
Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis treatment 3 completed NCT06178822
Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room No drug interventions Not Available Not Available recruiting NCT05565222
Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care Unit treatment 3 recruiting NCT02186522
Immune Failure in Critical Therapy (INFECT) Study No drug interventions Not Available Not Available completed NCT02579525
Targeted Tissue Perfusion Versus Macrocirculatory-guided Standard Care in Patients With Septic Shock No drug interventions treatment Not Available completed NCT04915625
A Prediction Model of 28-day Mortality in Septic Shock No drug interventions Not Available Not Available unknown_status NCT05726825
Efficacy of add-on Plasma Exchange as an Adjunctive Strategy Against Septic Shock No drug interventions treatment Not Available not_yet_recruiting NCT03749525
Shenfu Injection Improves Arterial Vascular Reactivity No drug interventions treatment 2 / 3 unknown_status NCT01223430
Simultaneously Using Traditional Chinese Medicine (Si-Ni-Tang) to Treat Septic Shock Patients No drug interventions treatment 2 terminated NCT06072430
A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02) No drug interventions treatment 3 recruiting NCT02195830
Inferior Vena Cava Collapsibility Index in Severe Sepsis No drug interventions diagnostic Not Available unknown_status NCT04690530
Cerebral Hemodynamics and Oxygenation in Critically Ill Patients No drug interventions Not Available Not Available unknown_status NCT02203630
Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients treatment 4 terminated NCT02454348
NOrepinephrine and VasoprEssin Versus Norepinephrine aLone in Critically Ill Patients With Septic Shock treatment 4 withdrawn NCT03948048
Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock No drug interventions Not Available Not Available recruiting NCT06072248
Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation treatment 1 / 2 completed NCT04178148
Personalized Dose Optimization of Amikacin Guided by Pharmacokinetic Modeling Software in Patients With Septic Shock No drug interventions other Not Available completed NCT02427048
Clinical Practice Guidelines and Impact of Audit and Feedback in the Emergency Department No drug interventions health_services_research Not Available completed NCT02835157
Balanced Crystalloid vs. Saline in Children With Septic Shock treatment Not Available completed NCT05325957
Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock in Angers University Hospital No drug interventions Not Available Not Available withdrawn NCT01770457
Cytokine Response in Septic Shock No drug interventions Not Available Not Available unknown_status NCT03754257
Effects of Electrical Stimulation for Preventing Loss of Muscle Mass in Patients With Sepsis No drug interventions treatment Not Available recruiting NCT04644926
The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis No drug interventions treatment 1 / 2 completed NCT03655626
Implementation and Evaluations of Sepsis Watch No drug interventions treatment Not Available completed NCT06242626
Euthyroid Sick Syndrome in Septic Shock No drug interventions Not Available Not Available completed NCT05839366
Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients treatment 3 recruiting NCT03226366
Effect of Emergency Department Care Reorganization on Door-to-antibiotic Times for Sepsis (LDS SWARM) No drug interventions Not Available Not Available completed NCT00000574
Ibuprofen in Sepsis Study treatment 3 completed NCT03892174
Cytokine REmoval in CRitically Ill pAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE) No drug interventions treatment Not Available recruiting NCT04152174
Safety and Efficiency of Combined Extracorporeal Blood Purification in Neurosurgical ICU. Prospective RCT No drug interventions treatment Not Available unknown_status NCT03034174
Pharmacokinetics of High-dose Tigecycline in Critically Ill Patients No drug interventions Not Available Not Available completed NCT04067674
Septic Shock-induced Immunosuppression No drug interventions Not Available Not Available recruiting NCT02887274
Application of Stimulated Immune Response Change to Predict Outcome of Patient With Severe Sepsis No drug interventions Not Available Not Available unknown_status NCT03366220
Resuscitation With Plasma in Surgical and Trauma Patients With Septic Shock No drug interventions treatment 2 terminated NCT03292120
Venous to Arterial Carbon Dioxide Difference (P₍ᵥ-ₐ₎CO₂): Predictor of Septic Patient Prognosis Depending on the ScvO₂ No drug interventions prevention Not Available completed NCT03756220
Ascorbic Acid and Thiamine Effect in Septic Shock treatment 2 completed NCT03996720
Early Identification and Effective Management of Pediatric Sepsis No drug interventions Not Available Not Available completed NCT01790620
Impact of CVVHD With Adsorption Capacity Membranes in Septic Acute Kidney Injury No drug interventions supportive_care Not Available completed NCT05193682
Right Ventricular Dysfunction in Septic Shock Patients in ICU No drug interventions Not Available Not Available not_yet_recruiting NCT05999682
Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis No drug interventions treatment 1 / 2 completed NCT01315782
Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis No drug interventions Not Available Not Available recruiting NCT01352182
Pharmacokinetic and Biomarker Study of Pioglitazone in Adolescents With Severe Sepsis and Septic Shock treatment 1 / 2 completed NCT04698382
Impact of COVID-19 on the Incidence, Characteristics, Management and Outcome of Sepsis No drug interventions Not Available Not Available withdrawn NCT04292431
Leukocyte MOrphology and CORticosteroids Response in SEPtic Patients (MOCORSEP) No drug interventions Not Available Not Available completed NCT04474431
Correlation of VEGF-A and Fluid Balance in Septic Shock No drug interventions other Not Available unknown_status NCT04470973
Pharmacokinetics of Amikacin and Cefuroxime in Critically Ill Patients. Not Available Not Available unknown_status NCT05902273
The Value of Peripheral Arterial Resistive Index in Evaluation of Tissue Perfusion in Patients With Septic Shock No drug interventions Not Available Not Available completed NCT00135473
Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) treatment 3 completed NCT00541827
Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis No drug interventions Not Available Not Available completed NCT02676427
Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination No drug interventions Not Available Not Available unknown_status NCT02025127
A Randomized Controlled Study of Enteral Nutrition in Septic Shock No drug interventions treatment Not Available completed NCT05389176
Effects of Heart Control at Different Stages in Patients of Septic Shock With Tachycardia treatment Not Available unknown_status NCT02002676
Prevalence and Outcome of Hypermetabolism in Initial Prevalence and Outcome of Hypermetabolism in Initial Phase of Intensive Care Unit Patient: a Prospective Observational Study No drug interventions Not Available Not Available unknown_status NCT01145560
A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock No drug interventions treatment 2 completed NCT05572060
Effect of Metformin Use on Mortality in Diabetic and Non Diabetic Patients With Sepsis and Septic Shock. treatment Not Available not_yet_recruiting NCT04320394
Evaluation of Sepsis-induced Immunosuppression Base on QuantiFERON Monitor® in Septic Shock No drug interventions basic_science Not Available withdrawn NCT06001294
We Collected Blood Samples From Septic Shock Patients and Measured ELABELA, Creatinine, and NGAL Levels. Survival After 7 Days Was Recorded and Analyzed to Evaluate the Potential of Serum ELABELA as an Early Diagnostic Marker for Sepsis-associated Acute Kidney Injury. No drug interventions Not Available Not Available recruiting NCT03434691
Effects of Dexmedetomidine vs Midazolam on Microcirculation in Septic Shock Patients screening Not Available unknown_status NCT06258291
First in Human Trial to Assess the Safety of HemoSystem REBOOT in Patients With Sepsis-induced Immunosuppression No drug interventions treatment Not Available not_yet_recruiting NCT03783091
A Trial of Vitamin B12 in Septic Shock treatment 2 recruiting NCT06217562
Vasopressin for Septic Shock Pragmatic Trial treatment 4 enrolling_by_invitation NCT03841162
Fast Assay for Pathogen Identification and Characterization No drug interventions Not Available Not Available completed NCT05207280
Clinical Trial Comparing Noradrenaline (NA) Plus Placebo Versus Noradrenaline Plus Terlipressin (TP) in Septic Shock treatment 3 recruiting NCT03456180
Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock No drug interventions Not Available Not Available completed NCT04136080
The Effect of Increasing the Mean Arterial Pressure on the Microcirculation and the Prognosis of Patients With Septic Shock No drug interventions treatment Not Available unknown_status NCT06076980
Heamodynamic Effects of Paracetamol in Septic Shock Patients other 4 completed NCT01304680
Evaluation of Fluid Resuscitation in Children With Cancer With Severe Sepsis / Septic Shock No drug interventions Not Available Not Available unknown_status NCT01415180
Life After Pediatric Sepsis Evaluation No drug interventions Not Available Not Available completed NCT03623529
A Study of LJPC-501 in Paediatric Patients With Hypotension Associated With Distributive or Vasodilatory Shock treatment 2 unknown_status NCT00811629
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients No drug interventions Not Available Not Available completed NCT03557229
Clinical Trial of Antioxidant Therapy in Patients With Septic Shock treatment 3 unknown_status NCT02825329
Open-label Evaluation of Polymyxin B Hemoperfusion for Septic Shock No drug interventions Not Available Not Available temporarily_not_available NCT05612529
Fluid Responseveness in Sepsis and Its Correlation to CVP No drug interventions Not Available Not Available terminated NCT04728529
Septic Shock Management Guided by Ultrasound: SEPTICUS Trial No drug interventions treatment Not Available unknown_status NCT05194189
Clinical Efficacy of Megadose Vitamin C in Sepsis treatment 2 recruiting NCT04759989
Fluid Resuscitation in Septic Shock Patients With BMI Elevation No drug interventions treatment Not Available terminated NCT00711789
Angiotensin in Septic Kidney Injury Trial treatment 2 unknown_status NCT01139489
Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's) No drug interventions treatment Not Available completed NCT01600989
Mitochondrial Function of Immune Cells in Sepsis No drug interventions Not Available Not Available completed NCT03663192
Strain Echocardiography During Septic Shock : an Observational Pilot Study No drug interventions Not Available Not Available completed NCT03388944
PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis No drug interventions supportive_care Not Available completed NCT03644940
Subpopulation-Specific Sepsis Identification Using Machine Learning No drug interventions diagnostic 2 withdrawn NCT03104140
Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock treatment 3 completed NCT02442440
Anisodamine Critically Ill SeptIc Shock treatment 1 / 2 completed NCT04388267
Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery No drug interventions Not Available Not Available unknown_status NCT02547467
TOADS Study: TO Assess Death From Septic Shock. No drug interventions Not Available Not Available unknown_status NCT05928767
Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock. No drug interventions Not Available Not Available recruiting NCT03643367
Sevoflurane Sedation in Patients With Septic Shock treatment 2 not_yet_recruiting NCT04979767
Function of Circulating Exosomes in Sepsis-induced Immunosuppression No drug interventions Not Available Not Available unknown_status NCT03931967
Proadrenomedullin and Microcirculation in Monitoring Organ Dysfunction in Patient With Infection No drug interventions Not Available Not Available completed NCT05824767
Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock treatment 4 recruiting NCT03654001
ALBumin Italian Outcome Septic Shock-BALANCED Trial (ALBIOSS-BALANCED) treatment 3 unknown_status NCT06306001
Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock treatment 2 / 3 not_yet_recruiting NCT04571801
Optimization of Sepsis Therapy Based on Patient-specific Digital Precision Diagnostics No drug interventions diagnostic Not Available unknown_status NCT05931601
Early Initiated Vasopressor Therapy in the Emergency Department treatment 3 recruiting NCT01926301
Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy No drug interventions Not Available Not Available withdrawn NCT00147004
Corticosteroid Therapy of Septic Shock - Corticus treatment 3 completed NCT04947904
OPTImized Restrictive Strategy Targeting Non-Resuscitative FLUIDs in Septic Shock: Pilot Study. No drug interventions prevention Not Available completed NCT02120404
Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic Shock treatment 2 active_not_recruiting NCT06181604
Multicenter Symphony IL-6 Monitoring Sepsis ICU Study No drug interventions Not Available Not Available active_not_recruiting NCT06156072
Ultrasound-guided Blood Sampling Drawing for Microbiological Analysis in the Critically Ill No drug interventions Not Available Not Available not_yet_recruiting NCT04089072
Methylene Blue as a Third-line Vasopressor in Septic Shock treatment 2 recruiting NCT03661268
The Effect of Rapid Fluid Challenge Under Pulmonary Artery Catheter Monitoring on Physiological Indexes of Patients With Septic Shock No drug interventions treatment Not Available unknown_status NCT04117568
The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients No drug interventions Not Available Not Available terminated NCT03151668
Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients treatment 3 unknown_status NCT04339868
Terlipressin for Refractory Septic Shock treatment 2 recruiting NCT03311568
Microcirculatory Alterations in Critical Disease: New Ultrasound Technology No drug interventions diagnostic Not Available terminated NCT01046669
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock No drug interventions treatment Not Available completed NCT01378169
SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU No drug interventions Not Available Not Available completed NCT03338569
Vitamin C and Septic Shock treatment 2 / 3 completed NCT03137446
Restrictive Intravenous Fluids Trial in Sepsis No drug interventions treatment Not Available completed NCT02640846
Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock treatment 4 unknown_status NCT02766946
Diaphragmatic Atrophy Related to Mechanical Ventilation No drug interventions other Not Available completed NCT04508946
Triple Therapy in Septic Shock Patients treatment 3 completed NCT03249246
Epidemiology of Sepsis in Turkish ICUs. No drug interventions Not Available Not Available completed NCT03700346
Muscle Lactate and Lactate to Pyruvate Ratio Clearance in Septic Shock Patients No drug interventions other Not Available completed NCT03582046
Targeting Abdominal Perfusion Pressure in Septic Shock No drug interventions treatment Not Available terminated NCT04589546
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock? treatment 3 recruiting NCT01685112
Comparison of ECMO Use and Conventional Treatment in Adults With Septic Shock No drug interventions Not Available Not Available unknown_status NCT02150512
Resuscitation Strategies in Septic Shock No drug interventions treatment Not Available unknown_status NCT03078712
Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study No drug interventions treatment Not Available completed NCT04593212
Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA No drug interventions Not Available Not Available recruiting NCT00814112
Glycosaminoglycans During Septic Shock - a Temporal Study No drug interventions Not Available Not Available withdrawn NCT00134212
Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock treatment 2 completed NCT04365010
Low-chlorine Vs High-chlorine Crystalloids in Septic Shock Adults treatment 4 unknown_status NCT01697410
Continuos Terlipressin Infusion in Septic Shock treatment Not Available unknown_status NCT06481410
Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock treatment Not Available not_yet_recruiting NCT03136081
Candida Host Defense Response After Septic Shock in the Critically Ill No drug interventions Not Available Not Available completed NCT02393781
Adrenomedullin and Outcome in Severe Sepsis and Septic Shock No drug interventions Not Available Not Available completed NCT02174081
ARDS Prediction Score in Critically Ill Patients in China No drug interventions Not Available Not Available completed NCT03037281
Release of Nociceptin From Granulocytes in Sepsis No drug interventions Not Available Not Available completed NCT04913181
Artificial Intelligence for Sepsis Prediction in ICU No drug interventions Not Available Not Available unknown_status NCT03817281
Collective Accuryn Physiologic Signals and Signatures No drug interventions Not Available Not Available withdrawn NCT06572995
Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock No drug interventions Not Available Not Available recruiting NCT04516395
Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae No drug interventions treatment Not Available unknown_status NCT04747795
Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments treatment 3 completed NCT05401695
The Role of Blood Purification by Hemoadsorption as Adjunctive Treatment in Children With Septic Shock No drug interventions treatment Not Available completed NCT05874895
MAnual Lymphatic DrAinage to iMprove the outcomE of Patients After Septic Shock No drug interventions treatment Not Available recruiting NCT03716895
Severe Septic Shock Complications No drug interventions Not Available Not Available unknown_status NCT03308214
The Analysis of Factors Influencing the Vd of Imipenem in Septic Shock Patients Not Available Not Available completed NCT01213914
Hemofiltration in Burns: RESCUE (Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure) No drug interventions treatment Not Available unknown_status NCT03821714
Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock treatment Not Available completed NCT00279214
Hemodynamic and Perfusion Response to Drotrecogin Alfa (Activated) in Patients With Septic Shock treatment 4 completed NCT03336814
Evaluation of Early Association of Terlipressin and Norepinephrine During Septic Shock; the TerliNor Study treatment 4 unknown_status NCT01271114
Hypertonic Saline and Terlipressin for Sepsis-associated Hypotension treatment 3 terminated NCT03389555
Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial treatment 2 / 3 completed NCT02508350
The Pharmacokinetics/Pharmacodynamics of High-dose Daptomycin in Patients With Septic Shock Not Available Not Available unknown_status NCT02335723
ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco® LPS Adsorber No drug interventions treatment Not Available terminated NCT01392508
IMproved PREdiction of Severe Sepsis in the Emergency Department No drug interventions Not Available Not Available completed NCT03080038
SQUEEZE Trial: A Trial to Determine Whether Septic Shock Reversal is Quicker in Pediatric Patients Randomized to an Early Goal Directed Fluid Sparing Strategy vs. Usual Care No drug interventions treatment Not Available completed NCT01919138
Outcomes of Severe Sepsis Patients in Surgical Intensive Care Units No drug interventions Not Available Not Available completed NCT01601938
Selenium Replacement and Serum Selenium Level in Severe Sepsis and Septic Shock Patients No drug interventions treatment 2 withdrawn NCT05778838
Midodrine Effect on the Mortality Rates in Septic Shock Patients treatment 4 recruiting NCT04257838
Monitoring of Piperacillin-Tazobactam and Meropenem Plasmatic Levels in Critical Patients Not Available Not Available unknown_status NCT01071343
Transcutaneous Electric Muscle Stimulation (TEMS) in Septic Patients No drug interventions prevention Not Available completed