Sodium Channel Blockers
- Sodium Channel Blockers
- Accession Number
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
Drug Drug Description Ranolazine An anti-anginal drug used for the treatment of chronic angina. Phenytoin An anticonvulsant drug used in the prophylaxis and control of various types of seizures. Disopyramide A class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Mexiletine A class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment. Triamterene A potassium-sparing diuretic used in the treatment of edema and in the management of hypertension. Lamotrigine A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. Amiloride A pyrizine compound used to treat hypertension and congestive heart failure. Moricizine An antiarrhythmic used to treat arrhythmias. Oxcarbazepine An anti-epileptic used in the treatment of partial-onset seizures. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Procainamide A medication used to treat life threatening ventricular arrhythmias. Tocainide An orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Propafenone A Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias. Flecainide A class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT). Encainide A voltage-gated sodium channel blocker used for management of atrial or ventricular fibrillation, atrial flutter, and ventricular tachycardia, that is no longer used due to proarrhythmic adverse effects. Ajmaline An antiarrhythmic used to manage a variety of forms of tachycardias. Aprindine Aprindine is a cardiac depressant used in arrhythmias. Tetrodotoxin For the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence. Eslicarbazepine acetate An anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy. Pilsicainide Pilsicainide has been investigated for the treatment of Paroxysmal Atrial Fibrillation. Eslicarbazepine An antiepileptic indicated as a monotherapy or adjunct therapy in the treatment of epilepsy. Carbamazepine An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. Ethotoin A hydantoin antiepileptic used to control tonic-clonic and complex partial seizures. Fosphenytoin An antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. Rufinamide An antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS). Lacosamide An antiepileptic drug used to treat partial onset seizures in adults.
- Drugs & Drug Targets