Tranquilizing Agents
- Name
- Tranquilizing Agents
- Accession Number
- DBCAT000398
- Description
A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.
- Drugs
Drug Drug Description 7-Nitroindazole Not Available Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Aceprometazine Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders. Adipiplon Investigated for use/treatment in insomnia and sleep disorders. Alnespirone Alnespirone is a small molecule drug. The usage of the INN stem '-pirone' in the name indicates that Alnespirone is a anxiolytic, buspirone derivative. Alnespirone has a monoisotopic molecular weight... Alpidem Alpidem is a small molecule drug. Alpidem has a monoisotopic molecular weight of 403.12 Da. Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Amperozide Amperozide is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily... Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Azaperone Azaperone is a pyridinylpiperazine and butyrophenone agent that is capable of eliciting neuroleptic sedative and antiemetic effects. It is subsequently employed predominantly as a veterinary tranquilizer and mainly for pigs... Benperidol A neuroleptic butyrophenone derivative indicated in the treatment of psychoses, manic episodes, and psychomotor agitation. Brilaroxazine Investigated for the treatment of schizophrenia and schizoaffective disorder. Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Bromperidol A first-generation butyrophenone antipsychotic used in the treatment of schizophrenia and other psychotic manifestations. Buspirone An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. Carpipramine Carpipramine is a small molecule drug. The usage of the INN stem '-pramine' in the name indicates that Carpipramine is a substance of the imipramine group. Carpipramine has a monoisotopic... Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Chlormezanone Used in the management of anxiety and in the treatment of muscle spasm. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Chlorprothixene A thioxanthene antipsychotic. Clobazam A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome. Clopenthixol Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Clorazepic acid A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. Clothiapine An atypical antipsychotic indicated in the treatment of acute psychosis, exacerbations of chronic psychosis, chronic psychosis, paranoid psychosis, and anxiety. Clozapine An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Cyclobenzaprine A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. Dapiprazole Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations. Deramciclane Investigated for use/treatment in anxiety disorders. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Dixyrazine Not Annotated Doramectin Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in... Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Ecopipam Ecopipam has been used in trials studying the treatment of Tourette's Syndrome, Lesch-Nyhan Disease, Pathological Gambling, and Self-injurious Behavior. Eglumetad Eglumetad is a small molecule drug. Eglumetad has a monoisotopic molecular weight of 185.07 Da. Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Estazolam A benzodiazepine used for the short-term management of insomnia. Etazolate Investigated for use/treatment in alzheimer's disease and neurologic disorders. Ethyl loflazepate Not Available Etifoxine A benzoxazine class drug primarily used as an anxiolytic, but that also possesses neuroprotective, neuroplastic, and anti-inflammatory properties; these effects are thought to arise due to modulation of GABAergic neurotransmission and neurosteroid synthesis. Etizolam A thienodiazepine derivative used to treat anxiety and insomnia. Fananserin Fananserin is a small molecule drug. The usage of the INN stem '-anserin' in the name indicates that Fananserin is a serotonin receptor antagonist. Fananserin has a monoisotopic molecular weight... Fencamfamin For the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy. Flesinoxan Flesinoxan is a small molecule drug. The usage of the INN stem '-oxan(e)' in the name indicates that Flesinoxan is a benzodioxane derivative. Flesinoxan has a monoisotopic molecular weight of... Fluanisone Not Annotated Fludiazepam Used for the short-term treatment of anxiety disorders. Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Fluperlapine Fluperlapine is a small molecule drug. Fluperlapine has a monoisotopic molecular weight of 309.16 Da. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Flurazepam A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Gepirone A serotonin receptor agonist used to treat major depressive disorder in adults Halazepam Used to relieve anxiety, nervousness, and tension associated with anxiety disorders. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Honokiol Honokiol is under investigation in clinical trial NCT00966953 (Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.). Iloperidone An atypical antipsychotic agent used to treat schizophrenia and manic or mixed episodes associated with bipolar I disorder in adults. Ipsapirone Ipsapirone is a small molecule drug. The usage of the INN stem '-pirone' in the name indicates that Ipsapirone is a anxiolytic, buspirone derivative. Ipsapirone has a monoisotopic molecular weight... Ketazolam A long-acting benzodiazepine used to manage anxiety and insomnia. Lamotrigine A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. Lithium carbonate A medication used to treat manic episodes of bipolar disorder. Lithium chloride An injection indicated for cardiac output measurement. Loprazolam Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent... Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Loxapine A antipsychotic used for the treatment of schizophrenia. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Melperone An atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients. Meprobamate An anxiolytic drug used for the short-term management of anxiety symptoms. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Midazolam A short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Molindone An antipsychotic used to treat schizophrenia. Nabilone A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Nemonapride Not Annotated Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Norclozapine Investigated for use/treatment in schizophrenia and schizoaffective disorders. Nordazepam A benzodiazepine indicated in the treatment of insomnia. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Osanetant Potential therapy for schizophrenia, depression and visceral pain. Oxazepam An intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia. Oxprenolol A non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Penfluridol Not Annotated Perazine A phenothiazine antipsychotic used in the acute and chronic treatment of psychotic disorders. Perospirone For the treatment of schizophrenia and acute cases of bipolar mania. Perphenazine A phenothiazine used to treat schizophrenia as well as nausea and vomiting. Phenibut Not Annotated Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Pinazepam A benzodiazepine indicated in the treatment of anxiety and severe insomnia. Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Pirenperone Pirenperone is a small molecule drug. The usage of the INN stem '-perone' in the name indicates that Pirenperone is a tranquillizer, neuroleptic, 4'-fluoro-4-piperidinobutyrophenone derivative. Pirenperone has a monoisotopic molecular... Prazepam A benzodiazepine used to manage more severe forms of anxiety disorders. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Promazine A phenothiazine used to manage schizophrenia. Quetiapine An atypical antipsychotic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Raclopride Raclopride has been used in trials studying Parkinson Disease. Remimazolam An ultra short-acting benzodiazepine used for the induction and maintenence of procedural sedation during short procedures. Remoxipride An discontinued atypical antipsychotic selective for dopamine D2 receptors. Reserpine For the treatment of hypertension Rimcazole Rimcazole is a small molecule drug. Rimcazole has a monoisotopic molecular weight of 321.22 Da. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Sertindole An atypical antipsychotic indicated in the treatment of schizophrenia. Spiperone Spiperone is a dopamine antagonist that binds dopamine and serotonin receptors. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Tandospirone Tandospirone has been used in trials studying the treatment of Schizophrenia. Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Temgicoluril Not Annotated Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Thiothixene An antipsychotic indicated for the management of schizophrenia. Tiapride A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism. Timiperone Timiperone is a small molecule drug. The usage of the INN stem '-perone' in the name indicates that Timiperone is a tranquillizer, neuroleptic, 4'-fluoro-4-piperidinobutyrophenone derivative. Timiperone has a monoisotopic molecular... Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Triazolam A benzodiazepine used for short term treatment of insomnia. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Trifluperidol Not Annotated Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Veralipride Not Annotated Vortioxetine A serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD). Zetidoline Zetidoline is a small molecule drug. Zetidoline has a monoisotopic molecular weight of 307.15 Da. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. ZK-93423 ZK-93423 is a beta-carboline with muscle relaxant activity with agonistic properties at the benzodiazepine receptor. Zolazepam Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It... Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. - Drugs & Drug Targets