- Tranquilizing Agents
- Accession Number
A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.
Drug Drug Description Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Clozapine An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Meprobamate An anxiolytic drug used for the short-term management of anxiety symptoms. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Loxapine A antipsychotic used for the treatment of schizophrenia. Remoxipride An discontinued atypical antipsychotic selective for dopamine D2 receptors. Promazine A phenothiazine used to manage schizophrenia. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Buspirone An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Clorazepic acid A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Midazolam A short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Flurazepam A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Halazepam Used to relieve anxiety, nervousness, and tension associated with anxiety disorders. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Oxazepam An intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia. Perphenazine A phenothiazine used to treat schizophrenia as well as nausea and vomiting. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Triazolam A benzodiazepine used for short term treatment of insomnia. Cyclobenzaprine A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Chlormezanone Used in the management of anxiety and in the treatment of muscle spasm. Estazolam A benzodiazepine used for the short-term management of insomnia. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Chlorprothixene A thioxanthene antipsychotic. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Ketazolam A long-acting benzodiazepine used to manage anxiety and insomnia. Prazepam A benzodiazepine used to manage more severe forms of anxiety disorders. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Molindone An antipsychotic used to treat schizophrenia. Thiothixene An antipsychotic indicated for the management of schizophrenia. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Sertindole An atypical antipsychotic indicated in the treatment of schizophrenia. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Vortioxetine A serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD). Etizolam A thienodiazepine derivative used to treat anxiety and insomnia. Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Bromperidol A first-generation butyrophenone antipsychotic used in the treatment of schizophrenia and other psychotic manifestations. Perazine A phenothiazine antipsychotic used in the acute and chronic treatment of psychotic disorders. Benperidol A neuroleptic butyrophenone derivative indicated in the treatment of psychoses, manic episodes, and psychomotor agitation. Clothiapine An atypical antipsychotic indicated in the treatment of acute psychosis, exacerbations of chronic psychosis, chronic psychosis, paranoid psychosis, and anxiety. Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Lithium carbonate A medication used to treat manic episodes of bipolar disorder. Clobazam A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome. Lamotrigine A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. Remimazolam An ultra short-acting benzodiazepine used for the induction and maintenence of procedural sedation during short procedures. Phenibut Not Annotated Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Reserpine For the treatment of hypertension Dapiprazole Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Nabilone A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Fencamfamin For the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy. Ethyl loflazepate Not Available Fludiazepam Used for the short-term treatment of anxiety disorders. Oxprenolol A non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Aceprometazine Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders. 7-Nitroindazole Not Available Osanetant Potential therapy for schizophrenia, depression and visceral pain. Deramciclane Investigated for use/treatment in anxiety disorders. Adipiplon Investigated for use/treatment in insomnia and sleep disorders. Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Perospirone For the treatment of schizophrenia and acute cases of bipolar mania. Amperozide Amperozide is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily... Etifoxine A benzoxazine class drug primarily used as an anxiolytic, but that also possesses neuroprotective, neuroplastic, and anti-inflammatory properties; these effects are thought to arise due to modulation of GABAergic neurotransmission and neurosteroid synthesis. Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Melperone An atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients. Brilaroxazine Investigated for the treatment of schizophrenia and schizoaffective disorder. Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Azaperone Azaperone is a pyridinylpiperazine and butyrophenone agent that is capable of eliciting neuroleptic sedative and antiemetic effects. It is subsequently employed predominantly as a veterinary tranquilizer and mainly for pigs... Doramectin Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in... Zolazepam Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It... Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Gepirone Gepirone has been used in trials studying the treatment of Cocaine-Related Disorders. Ecopipam Ecopipam has been used in trials studying the treatment of Tourette's Syndrome, Lesch-Nyhan Disease, Pathological Gambling, and Self-injurious Behavior. Raclopride Raclopride has been used in trials studying Parkinson Disease. Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Tandospirone Tandospirone has been used in trials studying the treatment of Schizophrenia. Tiapride A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism. Pinazepam A benzodiazepine indicated in the treatment of anxiety and severe insomnia. Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Mebicar Not Annotated Veralipride Not Annotated Trifluperidol Not Annotated Loprazolam Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent... Fluanisone Not Annotated Dixyrazine Not Annotated Penfluridol Not Annotated Clopenthixol Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Nordazepam A benzodiazepine indicated in the treatment of insomnia. Lithium chloride An injection indicated for cardiac output measurement. Norclozapine Investigated for use/treatment in schizophrenia and schizoaffective disorders. Spiperone Spiperone is a dopamine antagonist that binds dopamine and serotonin receptors. ZK-93423 ZK-93423 is a beta-carboline with muscle relaxant activity with agonistic properties at the benzodiazepine receptor.
- Drugs & Drug Targets